AutismKB 2.0

Annotation Detail for PRKD2


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Basic Information Top
Gene Symbol:PRKD2 ( PKD2 )
Gene Full Name: protein kinase D2
Band: 19q13.2
Quick LinksEntrez ID:25865; OMIM: 607074; Uniprot ID:KPCD2_HUMAN; ENSEMBL ID: ENSG00000105287; HGNC ID: 17293
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
P00056VEGF signaling pathway
P00018EGF receptor signaling pathway
P00005Angiogenesis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1841Stomach cancer
2051Leukemia
Desease Name
CANCER
Chronic lymphocytic leukemia
Desease Name
Chronic lymphocytic leukemia
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PRKD2 mRNAaffects expression 21346803
D001151 Arsenic Arsenic affects the expression of PRKD2 mRNAaffects expression 18414638
D010126 Ozone Ozone results in decreased expression of PRKD2 mRNAdecreases expression 12763052
D012643 Selenium Selenium results in increased expression of PRKD2 mRNAincreases expression 19244175
D014635 Valproic Acid Valproic Acid results in increased expression of PRKD2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.028875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D018246 Adrenocortical Adenoma Arsenic 5.8217306315
MESH:D000544 Alzheimer Disease Ozone 2.5015513908
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D020261 Arsenic Poisoning Arsenic 2.9418414634 16835338 12569548 16251483
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6215570426
MESH:D001249 Asthma Ozone 2.7217854713 16373670
MESH:D050197 Atherosclerosis Arsenic 3.4412928151 19371607
MESH:D001321 Autistic Disorder Valproic Acid 1.9818316065 18396377 20603192 17688650 17507914 19460635 15238991 18558336 19232924 18775368 17157402 18940202 18177632 18985861 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 3.2317594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.618888407
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9617626835 18417511 14754758 18315731 16777450 15516495 19059883
MESH:D002100 Cachexia Ozone 5.2816183385
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7615504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.2816705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.2817306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7717687452 15504454 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.4218640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6815738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.6416973168 18022660
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D003092 Colitis Selenium 4.2617936198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.7821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Selenium 6.7815131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.781733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.451851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.643659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.533922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.917562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.603659116
MESH:D005234 Fatty Liver Valproic Acid 3.6719224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.578888407 18558336
MESH:D005534 Foot Diseases Arsenic 6.176392382
MESH:D006333 Heart Failure Selenium 3.2717162251
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.8017050553
MESH:D006973 Hypertension Arsenic 2.989931084 16076760 11953799
MESH:D006987 Hypesthesia Arsenic 6.1716093927
MESH:D007251 Influenza, Human Selenium 4.8116624496
MESH:D007642 Keratosis Arsenic 5.5312749816 16930632
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2816705839
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell marker/mechanism 18758461
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7717339181
MESH:D008107 Liver Diseases Arsenic 2.6111134558
MESH:D008113 Liver Neoplasms Arsenic 2.7816368122
MESH:D008171 Lung Diseases Ozone 3.6019066396 8266340
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D055370 Lung Injury Ozone 4.3320417186
MESH:D008175 Lung Neoplasms Arsenic 2.8119168569 17976673 17306315
MESH:D008175 Lung Neoplasms Ozone 2.817614698 8597069
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9715318939
MESH:D008654 Mesothelioma Selenium 2.9015107826
MESH:D008679 Metaplasia Ozone 5.7210496685
MESH:D008881 Migraine Disorders Valproic Acid 3.4418765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3317596541
MESH:D017202 Myocardial Ischemia Arsenic 4.2715371236
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009436 Neural Tube Defects Arsenic 8.1816620997
MESH:D009436 Neural Tube Defects Valproic Acid 8.1816359493 8888407
MESH:D020078 Neurogenic Inflammation Arsenic 4.7817056641
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7816049721 12819281
MESH:D010051 Ovarian Neoplasms Arsenic 2.8317306315
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.6216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.5316905509 6392382 15371236
MESH:D010538 Peritonitis Ozone 4.6116369182
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D011014 Pneumonia Ozone 4.9318929643 18007984 18381685
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.3720603192
MESH:D011471 Prostatic Neoplasms Arsenic 3.5516140617
MESH:D011507 Proteinuria Arsenic 4.4121343184
MESH:D019310 Pseudolymphoma Valproic Acid 5.1512752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5819155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 6.7218551238
MESH:D012640 Seizures Valproic Acid 6.7211044598 16876388 3137016 11738929 1511512 14763951 15475178 17978042
MESH:D012871 Skin Diseases Arsenic 2.8217548696 19834688 16702368 6392382 17050553 17453740 18709164 15952646 16353154 17938729 16759981
MESH:D012878 Skin Neoplasms Arsenic 3.1517976673 17050553 17029826 19538983 16251483 15504454
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0619490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.5916049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.5911144890 15987713 19322015 19429237 18640142 17976673 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
MESH:D014652 Vascular Diseases Arsenic 5.2817056641
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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