AutismKB 2.0

Annotation Detail for BRP44


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Basic Information Top
Gene Symbol:BRP44 ( DKFZp564B167,MGC125752,MGC125753 )
Gene Full Name: brain protein 44
Band: 1q24
Quick LinksEntrez ID:25874; OMIM: NA; Uniprot ID:BR44_HUMAN; ENSEMBL ID: ENSG00000143158; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of BRP44 mRNAaffects expression 17562736
D003520 Cyclophosphamide BRP44 protein affects the susceptibility to Cyclophosphamideaffects response to substance 16217747
D016572 Cyclosporine Cyclosporine results in decreased expression of BRP44 mRNAdecreases expression 20106945
D005472 Fluorouracil BRP44 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D008942 Mitoxantrone BRP44 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Fluorouracil 2.4917638652
MESH:D000740 Anemia Fluorouracil 4.0615504547 17963324 16511603
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001161 Arteriosclerosis Cyclophosphamide 5.0815014928
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.5012006526 18323546 18234424 15093573 17388661 15136595 11325840 17020986 16978400
MESH:D001943 Breast Neoplasms Fluorouracil 2.5016557594 16110121 18357371 15136595 19217205 16595493 18608205
MESH:D002276 Carcinoid Tumor Fluorouracil 5.2816051944
MESH:D002277 Carcinoma Fluorouracil 3.8517121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.923084413
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 4.9219701751
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.9216799960 17045692 18930000 16332177 17971768 17088986
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.4316152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 7.2816201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 7.2818695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5717066447 16280240 18986760 16757204
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2817725105 17018589 16510598 17016597 18772588 17169374 15001691 17287894 17172411 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017594712 16391804 16303861 20501625 17454858 18448328 18509181 18802399 18383874 16331619 14970324 16524972 18288408 16282729 17255274 17401013 17016601 17695437 15289873 15148649 18949393 17094418
MESH:D003556 Cystitis Cyclophosphamide 5.6016651033 18483878 16989017 12913760 18710439 17979934 17010015 10700343 12161096 15643279 10498854 18433785 15276878 16413132 16614059 12388444 18093676 18295254 18372110 11948286
MESH:D007644 Darier Disease Fluorouracil 5.3316733453
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.3715331540 10990075 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.3018772604
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6610774834 12540782 16081117 16781746 11834606 14550746 14986274 11529661 17522070 17906064 16177239 19739265 12392966 11287661 17562736 14725611 11461765 10915739 19370779 15619225 12705907 12594235 16227642 19164858 11421492 18713872 19416960 19420014 18071297 16485898 12958197 11739529 16393943 11743745 19085960 2444490 16109766 12153990 15968718 19923254 10663392
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004802 Eosinophilia Cyclophosphamide 4.7011006010
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5216337965 17638652 16785472 16481741 15173087
MESH:D005234 Fatty Liver Cyclosporine 3.2319224547
MESH:D005355 Fibrosis Cyclosporine 3.6212168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D005910 Glioma Fluorouracil 2.9816145905
MESH:D018316 Gliosarcoma Cyclophosphamide 6.0511389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.5215172196 11014644 16376943
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6115102660 15162350 18337622
MESH:D006331 Heart Diseases Mitoxantrone 4.3916019553
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.7711918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 6.1514986274
MESH:D006689 Hodgkin Disease Cyclophosphamide 4.1117606976 16135485
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007154 Immune System Diseases Cyclophosphamide 5.9416076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.847193160 16517039
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Acetaminophen 6.4112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.4118776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 8.4212371664
MESH:D007680 Kidney Neoplasms Fluorouracil 8.4216985049
MESH:D007938 Leukemia Cyclophosphamide 3.6410602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 7.3917008537 18587576 17658394 17296974 18172266 17802794
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 7.3918172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.3510373061
MESH:D007970 Leukopenia Cyclophosphamide 5.5111830472 10052129
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 19784758 19014921 16610002 19460945 12587719 11587558 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Fluorouracil 2.5817045692 16603448 18383874 15113037
MESH:D008175 Lung Neoplasms Fluorouracil 2.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.3315086387
MESH:D008223 Lymphoma Cyclophosphamide 4.0812854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 5.0016675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.4711911406
MESH:D008546 Melanoma, Experimental Acetaminophen 12.5019513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 12.5016388313
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9018986760 16757204
MESH:D009369 Neoplasms Cyclophosphamide 9.4518854779
MESH:D009369 Neoplasms Fluorouracil 9.4518239605 18600527 16928823
MESH:D009369 Neoplasms Mitoxantrone 9.4516640825
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009447 Neuroblastoma Cyclophosphamide 3.8015176712 16115947 8761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.438761367 12837982
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6616436463
MESH:D009503 Neutropenia Cyclophosphamide 4.738291058
MESH:D009845 Oligospermia Cyclophosphamide 5.2516517039
MESH:D010146 Pain Acetaminophen 7.8816870215
MESH:D010146 Pain Cyclophosphamide 7.8812161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.9511332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.9516929163 19003803 16500647 15113037
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.9821297632
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 3.5117136230
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.5119082440 18626508
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3916636934
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3418286688 15538739 16160472 18722050
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.2316636934
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 6.0516517039
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018567086 18396642 16951190 16424979 19015929 17498489 19084572 17522103 15786421 17172411
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.6012837982
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3416280240
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 3.2514692829
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.2316803524
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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