AutismKB 2.0

Annotation Detail for TMEM186


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Basic Information Top
Gene Symbol:TMEM186 ( C16orf51,DKFZp564K2062 )
Gene Full Name: transmembrane protein 186
Band: 16p13.2
Quick LinksEntrez ID:25880; OMIM: NA; Uniprot ID:TM186_HUMAN; ENSEMBL ID: ENSG00000184857; HGNC ID: 24530
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TMEM186 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TMEM186 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen affects the expression of TMEM186 mRNAaffects expression 17555576
D014810 Vitamin E Vitamin E results in increased expression of TMEM186 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.2714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Tamoxifen 2.1717242785 19084267 19244106 17440819 16273361 16202921 16818667 17049068 19103187 15565566 18351453 19189210 20065188 21138602 19289846 18855134 19059307 19189212 19155303 19200415 18997820 19142967 20135344 15668708 11161223 21152245 20859285 19221464 19066611 17261762 18821012 19288272 18984771 19410462 20005174 19115204 18425577 18815881 17893378 20390343 19011961 20544844 16873071 18629630 19487384
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4916050911
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 5.0719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.983084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 2.9816924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 4.0117572228
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1717110522 16919318 17333356 16105132 15861022 17681005 11677210
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9319769572
MESH:D003711 Demyelinating Diseases Tamoxifen 4.9219031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8419279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6716485898 14725611 19164858 19739265 12392966 11287661 2444490 11739529 16227642 12153990 16393943 11529661 12594235 16781746 19923254 11461765 11834606 10915739 12958197 11743745 16177239 14550746 19420014 15968718 17562736 17906064 15619225 11421492 10774834 19416960 14986274 16109766 19085960 12540782 19370779 17522070 16081117 12705907 18713872 10663392 18071297
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:C538011 Eales disease Vitamin E 5.439068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.6812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.6819031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2920544844 16202921 17893378 19155303
MESH:D005234 Fatty Liver Ethinyl Estradiol 9.1415345470
MESH:D005234 Fatty Liver Tamoxifen 9.1414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.1614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.8119069698
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1716080930
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8116490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.6914716179
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007021 Hypospadias Ethinyl Estradiol 4.3716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007249 Inflammation Tamoxifen 2.5319457130
MESH:D007251 Influenza, Human Vitamin E 4.9416624496
MESH:D007674 Kidney Diseases Acetaminophen 6.6512587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 6.6512488133
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3818625569
MESH:D008064 Lipidoses Tamoxifen 3.4315342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.6218564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.6216169303
MESH:D008107 Liver Diseases Acetaminophen 1.7019014921 12969438 16610002 16611625 19460945 19784758 12587719 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008113 Liver Neoplasms Tamoxifen 2.3316684651
MESH:D008171 Lung Diseases Vitamin E 3.4316863852
MESH:D008175 Lung Neoplasms Tamoxifen 2.5818625569
MESH:D008175 Lung Neoplasms Vitamin E 2.5811062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3919428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8614580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.2719453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.8115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6119410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.7219200415 19189210 19196722
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1715067354
MESH:D011471 Prostatic Neoplasms Vitamin E 3.1715084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.9416919318 15861022
MESH:D012871 Skin Diseases Vitamin E 2.5218709164
MESH:D013088 Spermatocele Ethinyl Estradiol 14.1116709447
MESH:D013088 Spermatocele Tamoxifen 14.1116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.6719457130
MESH:D020521 Stroke Vitamin E 3.8416517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4817572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8014692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9715869587 14671159
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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