AutismKB 2.0

Annotation Detail for ABI3BP


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Basic Information Top
Gene Symbol:ABI3BP ( FLJ41743,FLJ41754,NESHBP,TARSH )
Gene Full Name: ABI family, member 3 (NESH) binding protein
Band: 3q12.2
Quick LinksEntrez ID:25890; OMIM: 606279; Uniprot ID:TARSH_HUMAN; ENSEMBL ID: ENSG00000154175; HGNC ID: 17265
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2066Lung cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ABI3BP mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ABI3BP mRNAdecreases expression 20713471
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ABI3BP mRNAdecreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of ABI3BP mRNAdecreases expression 20106945
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of ABI3BP mRNAdecreases expression 20713471
D010634 Phenobarbital Phenobarbital affects the expression of ABI3BP mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of ABI3BP mRNAaffects expression 19136022
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ABI3BP mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.656195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6511752688 14514962 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.366695378
MESH:D000236 Adenoma Methylcholanthrene 7.366695378 10545420
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.7517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.7516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.7516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.6011922910
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8817474063 20146248
MESH:D001943 Breast Neoplasms Methylcholanthrene 1.8817474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1418705752 15673190 15700767 16227642 15721981 16097048 16050911 16124888 3786805 10355542 16192424 16011737
MESH:D002277 Carcinoma Methylcholanthrene 9.0810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.0816835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1518788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.1517173139 1701930 6705139 20935162 20007298
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4612371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.4616192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Cyclosporine 8.4419486331
MESH:D002779 Cholestasis pirinixic acid 8.4419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2016354765 15668235 12621046 8697196 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.9515968718 3732212 9327722 6623471 19085960 11566570 16177239 15998439 7120509 2869522 7440962 15027814 17522070 6884620 4309450 10915739 19336974 7179309 3786805 16227642 10092053 21278145
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.3111558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.7516045604 19224547 17595544 12631006 15959796 61145 16239168 12795759
MESH:D005234 Fatty Liver Cyclosporine 14.7519224547
MESH:D005234 Fatty Liver pirinixic acid 14.7520131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.3410962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 16.9118705752
MESH:D005355 Fibrosis Cyclosporine 16.9112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.9120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 16.5816109766
MESH:D006529 Hepatomegaly pirinixic acid 16.5818467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.5816120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916959395 8697196 18606429 16354765 15340226
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Cyclosporine 5.2410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.488314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0916221502 11903743 17174718 11408273 16239168 16943688 21278145 17157831 17334410
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0921047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5316248980 16638106 15673190 18420326 18210741 11481614 17708605 18705752 14716496 15052691 17823541 18317297 12666154 18166357 15370692 18472094 14512876 18472332 17698563 17481882 17761835 17922224 12632514 16033810 12389079 12609069 15818738 18481824 18006644 14724832 14620537 16011737 15925388 17900296 17805973 16116963 15730626 15931870 15338365 18395095 18054572 15893842 12445418 15959796 16015684 15057751 12546737 17631135 17721639 20821823 12741479 12649538 18395914 17766677 15876570 17565644 12958196 15123356 12667390 18277467 12586293 12632512 13678700 16192424 18187930 16097048 16027843 17944888 18251166 18263696 18205269 15650968 18412020 14716833 17557913 16136751 18339082 14748882 15996030 17869086 18156304 17976157 10355542 18418968 18279442 12445421 15362042 18429990 17640975 18376398 12898905 17714472 17525996
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2915720792 17285989 16246199 16964402 15830285
MESH:D008107 Liver Diseases Phenobarbital 4.2919363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9514706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.2020195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.2019294768
MESH:D008113 Liver Neoplasms Phenobarbital 15.208742319 15975961 19073162 21047994 19482888 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 15.2020007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.2016984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.5112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 15.511399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.512563599 18308698 6150874 17172636 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.5112151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5718520028 18816296 17053015 18569708 20464547 20135361 20064080 20869020 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.5715390079 6695378 20970405 17909032 16271038 21163286 16337739 20512841 11893704 7750092 10545420 9230183 1399818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5719555203 11884234
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2211141357
MESH:D009369 Neoplasms pirinixic acid 5.2217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.8112371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.812563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012640 Seizures Phenobarbital 2.874039156 3137016 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2617053015
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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