Annotation Detail for PLEKHG4
Basic Information
Top
| Gene Symbol: | PLEKHG4 ( ARHGEF44,DKFZp434I216,PRTPHN1,SCA4 ) |
|---|
| Gene Full Name: | pleckstrin homology domain containing, family G (with RhoGef domain) member 4 |
|---|
| Band: | 16q22.1 |
|---|
| Quick Links | Entrez ID:25894; OMIM: 609526; Uniprot ID:PKHG4_HUMAN; ENSEMBL ID: ENSG00000196155; HGNC ID: 24501 |
|---|
| Relate to Another Database: |
SFARIGene;
denovo-db |
| Desease ID | Desease Name |
|---|
| 2055 | Spinocerebellar ataxias |
| Desease Name |
|---|
| Spinocerebellar ataxia-4 |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000638 |
Amiodarone |
Amiodarone results in increased expression of PLEKHG4 mRNA | increases expression | 19774075
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLEKHG4 mRNA | affects binding|decreases expression|increases activity | 19710929
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.72 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.37 | 16434500 |
| MESH:D001145 |
Arrhythmias, Cardiac |
|
Amiodarone |
4.31 | 20041841 18057881 18218290 |
| MESH:D001281 |
Atrial Fibrillation |
|
Amiodarone |
4.27 | 18651412 19698954 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
Amiodarone |
10.97 | 19483382 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
10.97 | 19483382 |
| MESH:D002311 |
Cardiomyopathy, Dilated |
|
Amiodarone |
3.02 | 19225199 15710769 |
| MESH:D002341 |
Carotid Artery Thrombosis |
|
Amiodarone |
5.97 | 18974383 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.19 | 19176532 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.61 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Amiodarone |
2.49 | 15265979 18218290 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
3.02 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
Amiodarone |
9.69 | 14986274 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
9.69 | 19236843 20131406 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.81 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
Amiodarone |
11.26 | 15265979 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
11.26 | 19772884 16221962 18467677 19176532 |
| MESH:D006937 |
Hypercholesterolemia |
|
Amiodarone |
4.42 | 8137927 9751232 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.69 | 20558911 |
| MESH:D007037 |
Hypothyroidism |
|
Amiodarone |
5.28 | 18020914 17991464 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.93 | 16306350 |
| MESH:D008064 |
Lipidoses |
|
Amiodarone |
3.85 | 17567588 15342952 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.95 | 15890375 20007298 16377806 |
| MESH:D008133 |
Long QT Syndrome |
|
Amiodarone |
3.96 | 17391786 15350150 11989578 |
| MESH:D008171 |
Lung Diseases |
|
Amiodarone |
3.68 | 12587719 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Amiodarone |
5.55 | 18516814 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.27 | 16239165 |
| MESH:D009181 |
Mycoses |
|
Amiodarone |
5.97 | 12754197 17974566 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.30 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.33 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.14 | 17405874 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.90 | 20558911 |
| MESH:D011658 |
Pulmonary Fibrosis |
|
Amiodarone |
2.99 | 11597910 12832656 12490602 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.58 | 19058328 |
| OMIM:609620 |
SHORT QT SYNDROME 1 |
|
Amiodarone |
5.97 | 18724381 |
| MESH:D020754 |
Spinocerebellar Ataxias |
marker/mechanism |
|
| |
| MESH:D013276 |
Stomach Ulcer |
|
Amiodarone |
3.86 | 18087811 |
| MESH:D013610 |
Tachycardia |
|
Amiodarone |
4.96 | 11238279 |
| MESH:D017180 |
Tachycardia, Ventricular |
|
Amiodarone |
4.86 | 19225199 |
| MESH:D013959 |
Thyroid Diseases |
|
Amiodarone |
5.83 | 19731979 |
| MESH:D013971 |
Thyrotoxicosis |
|
Amiodarone |
5.62 | 18020914 19584973 |
| MESH:D016171 |
Torsades de Pointes |
|
Amiodarone |
5.08 | 11989578 17467628 |
Related Pathway Information