AutismKB 2.0

Annotation Detail for AHCTF1


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Basic Information Top
Gene Symbol:AHCTF1 ( DKFZp434N093,ELYS,MST108,TMBS62 )
Gene Full Name: AT hook containing transcription factor 1
Band: 1q44
Quick LinksEntrez ID:25909; OMIM: 610853; Uniprot ID:ELYS_HUMAN; ENSEMBL ID: ENSG00000153207; HGNC ID: 24618
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of AHCTF1 mRNAaffects expression 17562736
D001151 Arsenic Arsenic affects the expression of AHCTF1 mRNAaffects expression 18414638
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AHCTF1 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A results in decreased expression of AHCTF1 mRNAdecreases expression 20678512
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of AHCTF1 mRNAdecreases expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of AHCTF1 mRNAdecreases expression 17557909
C045950 propiconazole propiconazole results in decreased expression of AHCTF1 mRNAdecreases expression 19423681
C446685 systhane systhane results in decreased expression of AHCTF1 mRNAdecreases expression 19423681
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of AHCTF1 mRNAincreases expression 19465110
C032910 triadimefon triadimefon results in decreased expression of AHCTF1 mRNAdecreases expression 19423681
C025643 vinclozolin vinclozolin affects the expression of AHCTF1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4317306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7519015723
MESH:D020261 Arsenic Poisoning Arsenic 2.9016835338 16251483 18414634 12569548
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D050197 Atherosclerosis Arsenic 3.3312928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001862 Bone Resorption bisphenol A 4.0011985600
MESH:D001943 Breast Neoplasms bisphenol A 2.0417123778
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0420435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516124888 16227642 10355542 15700767 16011737 16192424 16097048 15673190 3786805 16050911 18705752 15721981
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6617687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.703084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.7017306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7018788625
MESH:D002278 Carcinoma in Situ bisphenol A 5.1817123778
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7218922899 17687452 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2118640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.5417938729 15738583 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.4316973168 18022660
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8220889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9817333356 16105132 11677210 17681005 17110522 16919318 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.338697196 15668235 16354765 15340226 12621046
MESH:D002972 Cleft Palate triadimefon 6.3316781842
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8715322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities triadimefon 2.8715834900 16875885
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3411287661 10663392 15968718 12594235 11461765 14550746 17906064 19164858 18071297 12540782 14725611 12153990 16781746 16393943 19085960 16485898 19739265 11529661 11739529 17562736 11743745 19923254 19416960 19370779 12705907 2444490 18713872 10774834 16177239 16227642 10915739 11421492 16081117 16109766 17522070 12392966 12958197 14986274 11834606 15619225 19420014
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.347440962 10092053 11566570 15027814 4309450 21278145 16227642 2869522 15968718 10915739 9327722 6623471 19085960 7120509 19336974 15998439 17522070 3786805 16177239 7179309 6884620 3732212
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1616239168 12795759 15959796 61145 12631006 19224547 17595544 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1615345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.1918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.1920067830
MESH:D005534 Foot Diseases Arsenic 5.786392382
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4011294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly propiconazole 22.4117178688 17178689
MESH:D006529 Hepatomegaly systhane 22.4117178688 17178689
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 22.4112621046 15340226 16120746
MESH:D006529 Hepatomegaly triadimefon 22.4117178688 17178689
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5917050553
MESH:D006973 Hypertension Arsenic 5.3916076760 9931084 11953799
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D006987 Hypesthesia Arsenic 5.7816093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9617937319
MESH:D007248 Infertility, Male vinclozolin 6.9616467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 3.3816393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.7916580747
MESH:D007569 Jaw Abnormalities triadimefon 10.7915834900 15992940
MESH:D007642 Keratosis Arsenic 5.1812749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6417339181
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8816943688 11903743 21278145 16221502 17174718 16239168 17334410 17157831 11408273
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3218054572 18395914 14748882 17631135 18251166 16192424 18376398 12958196 12445418 15338365 18277467 18412020 16015684 18339082 17714472 12667390 14716496 15362042 17805973 12741479 17823541 15650968 12666154 17557913 17708605 16027843 15818738 12632514 17761835 15673190 18472332 12632512 17869086 17721639 17481882 14724832 18317297 17525996 16097048 12546737 16011737 18210741 15925388 18429990 16136751 10355542 16033810 15876570 17976157 16248980 18472094 18279442 18006644 15893842 15052691 15730626 16116963 13678700 17698563 17766677 18263696 18156304 12609069 20821823 17922224 17640975 14716833 12586293 18420326 18205269 18705752 12445421 12389079 15996030 15057751 15123356 15370692 12898905 16638106 18418968 17900296 18187930 15959796 11481614 12649538 18395095 18481824 14512876 18166357 17565644 14620537 17944888 15931870
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3212878042
MESH:D008107 Liver Diseases Acetaminophen 12.9319784758 12969438 16610002 16611625 19460945 19014921 12587719 11587558
MESH:D008107 Liver Diseases Arsenic 12.9311134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 12.9317285989 16964402 15720792 15830285 16246199
MESH:D008107 Liver Diseases propiconazole 12.9319363144
MESH:D008107 Liver Diseases triadimefon 12.9319363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8516899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 14.8116368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.8119294768
MESH:D008113 Liver Neoplasms propiconazole 14.8119028983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.8116984957
MESH:D008113 Liver Neoplasms triadimefon 14.8119028983
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 19.6312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental propiconazole 19.6317178689
MESH:D008114 Liver Neoplasms, Experimental systhane 19.6317178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.6312151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 19.6317178689
MESH:D008175 Lung Neoplasms Arsenic 2.4517976673 17306315 19168569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4511884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D017202 Myocardial Ischemia Arsenic 9.3815371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.3812213967
MESH:D009421 Nervous System Malformations bisphenol A 10.1316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1314600291
MESH:D009436 Neural Tube Defects Arsenic 3.5416620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.5217056641
MESH:D010049 Ovarian Diseases bisphenol A 5.1811985600
MESH:D010051 Ovarian Neoplasms Arsenic 2.7817306315
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1816905509 6392382 15371236
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 17.4410548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.4411118676 11222880 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 17.4418042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3520887781
MESH:D011471 Prostatic Neoplasms Arsenic 3.4316140617
MESH:D011471 Prostatic Neoplasms bisphenol A 3.4316740699
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D011507 Proteinuria Arsenic 4.1521343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 4.9810548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012871 Skin Diseases Arsenic 2.7819834688 16702368 15952646 18709164 17050553 16353154 17548696 6392382 17938729 16759981 17453740
MESH:D012878 Skin Neoplasms Arsenic 5.9117029826 19538983 17976673 15504454 17050553 16251483
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D019966 Substance-Related Disorders bisphenol A 4.1816045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms triadimefon 4.1917178689
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8611144890 17306315 19322015 17976673 15987713 19429237 18640142
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014591 Uterine Diseases bisphenol A 5.2314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014652 Vascular Diseases Arsenic 4.9317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6815869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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