AutismKB 2.0

Annotation Detail for GALNT3


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Basic Information Top
Gene Symbol:GALNT3 ( DKFZp686C10199,GalNAc-T3,HFTC,HHS,MGC61909 )
Gene Full Name: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
Band: 2q24.3
Quick LinksEntrez ID:2591; OMIM: 601756; Uniprot ID:GALT3_HUMAN; ENSEMBL ID: ENSG00000115339; HGNC ID: 4125
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00512O-Glycan biosynthesis
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
No data
No data
Desease Name
Tumoral calcinosis, hyperphosphatemic, familial
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of GALNT3 mRNAdecreases expression 18648102
C006632 arsenic trioxide arsenic trioxide results in increased expression of GALNT3 mRNAincreases expression 20458559
C006780 bisphenol A bisphenol A results in decreased expression of GALNT3 mRNAdecreases expression 15223131
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GALNT3 mRNAincreases expression 17942748
17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GALNT3 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil GALNT3 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D013629 Tamoxifen Tamoxifen affects the expression of GALNT3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GALNT3 mRNAaffects cotreatment|increases expression 17942748
D019772 Topotecan GALNT3 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014810 Vitamin E Vitamin E results in decreased expression of GALNT3 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma arsenic trioxide 7.3519825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.3514692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.3517638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Fluorouracil 9.3315504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.3311748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001862 Bone Resorption bisphenol A 4.0711985600
MESH:D001943 Breast Neoplasms bisphenol A 1.9817123778
MESH:D001943 Breast Neoplasms Fluorouracil 1.9818357371 16595493 16110121 16557594 18608205 19217205 15136595
MESH:D001943 Breast Neoplasms Tamoxifen 1.9819103187 17049068 16202921 19410462 19142967 19059307 18855134 21152245 20544844 18984771 17893378 19011961 15565566 18821012 15668708 19200415 18351453 19244106 18815881 18425577 19084267 16873071 19155303 19487384 18629630 16273361 20135344 20065188 19189212 18997820 19115204 19288272 19189210 21138602 11161223 19066611 16818667 20390343 19289846 19221464 20005174 17242785 17440819 20859285 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 8.7417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.827296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8215553829 11135700 15073043 14691202 16217749
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.8216332177 16799960 17045692 17971768 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8216924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.2717123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.787296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.7818695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5416280240 16757204 17066447 18986760
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.897505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.3619486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3617681005 17333356 16105132 17110522 16919318 15861022 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 12621046 15340226 16354765 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2618772588 17172411 16510598 17287894 15001691 17018589 17725105 17169374 16340194 17016597
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5920501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5916282729 18509181 18383874 17594712 16524972 18949393 15148649 18288408 20501625 17454858 17401013 17094418 16331619 16303861 17695437 17016601 18802399 18448328 17255274 14970324 16391804 15289873
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8710048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8719769572
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.068156756 11906362 12868966 2524372 18759878 14531868 8970840 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.8618692083 11289319 18289764 9022650 6679447 7440962 9653073 6482804 18648102 16192314 8291058 9328219 1440618
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1720544844 17893378 16202921 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.543581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.5412903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.5416785472 15173087 16481741 16337965 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver arsenic trioxide 14.3515073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.3515345470
MESH:D005234 Fatty Liver Tamoxifen 14.3519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5218337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9011294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9016080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3618606429 8697196 16959395 15340226 16354765
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tamoxifen 5.2119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2112878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.5316624496
MESH:D007333 Insulin Resistance bisphenol A 3.4116393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Vitamin E 2.9112488133
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.486582329
MESH:D007680 Kidney Neoplasms Fluorouracil 13.4816985049
MESH:D007680 Kidney Neoplasms Tamoxifen 13.4818625569
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 17050201 19850784 16968895 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3417107899 12679006 17712046 16966277 15336539 15748426 12712474 11161223 9834237 16823087 16891316 17869043 19035177 17217047 11468182 19225113 19642359 16330433 15213294 15622746 16112521 16331271 17649720 12018890 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5716169303
MESH:D008113 Liver Neoplasms arsenic trioxide 11.2814682389
MESH:D008113 Liver Neoplasms Fluorouracil 11.2816603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms Tamoxifen 11.2816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.51598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.5120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms arsenic trioxide 6.8119825857 11798837
MESH:D008175 Lung Neoplasms Fluorouracil 6.8115246190
MESH:D008175 Lung Neoplasms Tamoxifen 6.8118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.8111884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 6.8111062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7411731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7916757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2519417148 14977855 11468182 15949261 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.933581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms Fluorouracil 2.7018600527 16928823 18239605
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219189210 19196722 19200415
MESH:D009421 Nervous System Malformations bisphenol A 10.3911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.3914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.686679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6810525206
MESH:D009447 Neuroblastoma Topotecan 3.9415176712
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.616482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010049 Ovarian Diseases bisphenol A 5.2711985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4619769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5715580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.5716929163 19003803 16500647 15113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.4810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4811896295 11399792 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4120887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8619131511
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8618626508 19082440
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8615067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8615084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 5.0710548101
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1915538739 18286688 18722050 16160472
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5717007042
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5719015929 18396642 16951190 16424979 18567086 17172411 17498489 15786421 19084572 17522103
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.2716684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.681399818 6582329 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.6819014326
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
OMIM:211900 TUMORAL CALCINOSIS, HYPERPHOSPHATEMIC, FAMILIAL marker/mechanism
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.738074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.7312845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.7316712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
MESH:D014591 Uterine Diseases bisphenol A 5.3314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00512 Mucin type O-Glycan biosynthesis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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