AutismKB 2.0

Annotation Detail for NCR3


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Basic Information Top
Gene Symbol:NCR3 ( 1C7,CD337,LY117,MALS,NKp30 )
Gene Full Name: natural cytotoxicity triggering receptor 3
Band: 6p21.33
Quick LinksEntrez ID:259197; OMIM: 611550; Uniprot ID:NCTR3_HUMAN; ENSEMBL ID: ENSG00000204475; HGNC ID: 19077
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1707Multiple myeloma
1781Rheumatoid arthritis
1882Malaria
Desease Name
weight
METABOLIC
No data
Desease Name
Malaria, mild, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NCR3 mRNAaffects expression 16483693
D004786 Toxic Actions Toxic Actions results in decreased expression of NCR3 proteindecreases expression 18468695
D014212 Tretinoin Tretinoin results in decreased expression of NCR3 proteindecreases expression 17107666
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.3018287403
MESH:D000505 Alopecia Tretinoin 3.9815955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.3216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3416292516
MESH:D001249 Asthma Tretinoin 2.4416456186
MESH:D001471 Barrett Esophagus Tretinoin 4.9916935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.0916197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.3316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 6.0316168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.921917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3816051514 16096774
MESH:D002386 Cataract Tretinoin 3.3217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.3316129372
MESH:D002822 Choriocarcinoma Tretinoin 6.0316461808
MESH:D002972 Cleft Palate Tretinoin 2.819407595
MESH:D003092 Colitis Tretinoin 4.3517035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8317551590 9125849 16925845 9664655 10589399 14991402 9142499 9224671 8800419 9211117
MESH:D004489 Edema, Cardiac Tretinoin 5.3318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3716569247
MESH:D005124 Eye Abnormalities Tretinoin 3.9016938888 9664655
MESH:D005355 Fibrosis Tretinoin 4.1617994277
MESH:D005909 Glioblastoma Tretinoin 3.2717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 6.0316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.099664655 14991402
MESH:D006930 Hyperalgesia Tretinoin 3.5716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.2216778211
MESH:D007410 Intestinal Diseases Tretinoin 4.4217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.3917551590 15992940
MESH:D007938 Leukemia Tretinoin 2.9517143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1319850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.4216140955 12679006 17301526 17339181 17368321 17361223 19035177 16823087 16935935 17294898 19225113 19075265 16766008 19642359 15748426 17649720 16331271 16788101 19029980 17712046 17217047 17107899 9834237 17506722 16891316
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.629224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
OMIM:609148 MALARIA, MILD, SUSCEPTIBILITY TO marker/mechanism
MESH:D008527 Medulloblastoma Tretinoin 2.9217453147
MESH:D008545 Melanoma Tretinoin 1.9916752155
MESH:D008591 Meningomyelocele Tretinoin 5.0816940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.3017596541
MESH:D009369 Neoplasms Tretinoin 2.5916594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.369125849
MESH:D009436 Neural Tube Defects Tretinoin 3.329142499
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4516936753
MESH:D010146 Pain Tretinoin 3.2816870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5815976015
MESH:D011507 Proteinuria Tretinoin 4.1316636307
MESH:D011625 Pterygium Tretinoin 5.5416723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.6316116481 16283617
MESH:D012878 Skin Neoplasms Tretinoin 2.7816467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.3616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.2416051514
MESH:D014376 Tuberculosis Tretinoin 3.4716040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.1216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.4816752155
MESH:D014820 Vitiligo Tretinoin 4.6416761959
MESH:D009396 Wilms Tumor Tretinoin 4.3916287080
Pathway ID Pathway Name
KEGG:04650 Natural killer cell mediated cytotoxicity
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134883693
    • No data
    Releated disease ID Related disease Name
    PA443936Drug Hypersensitivity
    PA444109Exanthema
    PA162316739Maculopapular Exanthema
    Releated drug ID Related drug Name
    PA448785carbamazepine
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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