AutismKB 2.0

Annotation Detail for NALCN


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Basic Information Top
Gene Symbol:NALCN ( CanIon,FLJ23913,FLJ44659,FLJ44764,MGC74524,VGCNL1,bA430M15.1 )
Gene Full Name: sodium leak channel, non-selective
Band: 13q32.3-q33.1
Quick LinksEntrez ID:259232; OMIM: 611549; Uniprot ID:NALCN_HUMAN; ENSEMBL ID: ENSG00000102452; HGNC ID: 19082
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of NALCN mRNAaffects expression 17562736
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of NALCN mRNAdecreases expression 17005392
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of NALCN mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of NALCN mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3519490988
MESH:D000550 Amblyopia Valproic Acid 5.9617688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.9915469931
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.9017497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618985861 18177632 20603192 18775368 15238991 17507914 18558336 17688650 18316065 16609825 19232924 19460635 18940202 17157402 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.2420046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.638888407
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.5917129689 15324884
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.143084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.1415948411 16924424
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8220734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.918888407 17688650 16575769
MESH:D003456 Cryptorchidism Diethylstilbestrol 5.0616002989 12952375
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1016227642 11529661 17906064 11743745 11834606 15619225 19416960 10663392 18071297 18713872 11461765 15968718 19739265 16393943 16177239 11739529 12153990 10774834 14986274 2444490 12540782 17562736 11287661 19164858 12958197 19420014 12705907 19370779 16081117 12594235 16109766 16485898 14550746 12392966 19085960 19923254 16781746 17522070 10915739 11421492 14725611
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.1019641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004421 Dystonia Valproic Acid 4.511851702
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.3216402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.7016804899 15700306
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.713659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.6416628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.1118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.966426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.867750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.693659116
MESH:D005234 Fatty Liver Valproic Acid 3.7214986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.8716534752 16513791 16002989 16611131 15751030
MESH:D005315 Fetal Diseases Valproic Acid 5.6116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.648888407 18558336
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.5816452187
MESH:D006849 Hydrocephalus Valproic Acid 5.5017688650
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006965 Hyperplasia Diethylstilbestrol 5.0012960047 14722030
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.1916612254
MESH:D007021 Hypospadias Diethylstilbestrol 5.1416002989
MESH:D007246 Infertility Diethylstilbestrol 4.8615036965
MESH:D007674 Kidney Diseases Acetaminophen 2.4012587719 15629191
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.8015003126 16762066 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 4.6217184923
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.2016294345 17596541
MESH:D008107 Liver Diseases Acetaminophen 1.7011587558 19014921 12587719 12969438 16610002 19460945 16611625 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008113 Liver Neoplasms Diethylstilbestrol 2.7516712894 15890375
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.9817228818
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.7815166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.7515700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 6.2416002989
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008881 Migraine Disorders Valproic Acid 3.4718803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.458888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3517596541
MESH:D009369 Neoplasms Diethylstilbestrol 2.9315313581
MESH:D009421 Nervous System Malformations Diethylstilbestrol 4.6411399458
MESH:D009436 Neural Tube Defects Valproic Acid 3.3716359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.8914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.2315687265 16977796
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 12.0017184923
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 12.0020603192
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.5115846301 17136230 15046698
MESH:D019310 Pseudolymphoma Valproic Acid 5.2612752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.6419155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.993137016 15475178 14763951 11738929 11044598 16876388 1511512 17978042
MESH:D013088 Spermatocele Diethylstilbestrol 5.4316002989 16709447
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0919490988
MESH:D013226 Status Epilepticus Valproic Acid 5.2612833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.9617262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.153119515
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.8917306315 16452187 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.208888407
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.4316175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.8914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.5715809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 5.0016002989 16513791
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162396840
    • No data
    Releated disease ID Related disease Name
    PA446714Neoplasm, Residual
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450428methotrexate
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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