AutismKB 2.0

Annotation Detail for MYRIP


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Basic Information Top
Gene Symbol:MYRIP ( DKFZp586F1018,FLJ44025,MGC130034,MGC130035,SLAC2-C,SLAC2C )
Gene Full Name: myosin VIIA and Rab interacting protein
Band: 3p22.1
Quick LinksEntrez ID:25924; OMIM: 611790; Uniprot ID:MYRIP_HUMAN; ENSEMBL ID: ENSG00000170011; HGNC ID: 19156
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
sleep duration
Desease Name
Sleep duration
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MYRIP mRNAincreases expression 18648102
D001151 Arsenic Arsenic results in decreased expression of MYRIP mRNAdecreases expression 19654921
D007657 Ketone Bodies Ketone Bodies results in decreased expression of MYRIP mRNAdecreases expression 16807920
C008493 methylselenic acid methylselenic acid results in decreased expression of MYRIP mRNAdecreases expression 18548127
D010795 Phthalic Acids Phthalic Acids results in decreased expression of MYRIP mRNAdecreases expression 15728792
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MYRIP mRNAaffects binding|decreases expression|increases activity 19710929
C017947 sodium arsenite sodium arsenite results in increased expression of MYRIP mRNAincreases expression 16322246
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.1415276417
MESH:D018246 Adrenocortical Adenoma Arsenic 15.3217306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 15.3217306315 16712894
MESH:D020261 Arsenic Poisoning Arsenic 2.9312569548 16835338 16251483 18414634
MESH:D050197 Atherosclerosis Arsenic 3.4019371607 12928151
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.5420106747
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4611289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7317687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.867296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8616507464 17306315
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.8616507464 17306315 15276417
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.0615504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.0618572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3418640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6319152805 17938729 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 4.5616973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.357505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.3519524636 20056578
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.5219486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.5219176532
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.152524372 8156756 8970840 18759878 14531868 11298694 11906362 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.793621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0218692083 7440962 6482804 9653073 18289764 1440618 11289319 16192314 9022650 8291058 6679447 9328219 18648102
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.163581430
MESH:D005234 Fatty Liver pirinixic acid 3.0420131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005534 Foot Diseases Arsenic 6.006392382
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0816452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006529 Hepatomegaly pirinixic acid 3.3516221962 19176532 18467677 19772884
MESH:D006689 Hodgkin Disease sodium arsenite 3.4012676792
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7217050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D006973 Hypertension Arsenic 2.959931084 11953799 16076760
MESH:D006987 Hypesthesia Arsenic 6.0016093927
MESH:D007248 Infertility, Male sodium arsenite 3.1612646999 15346721
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007642 Keratosis Arsenic 5.3916930632 12749816
MESH:D007674 Kidney Diseases sodium arsenite 2.9420008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.206582329
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7217339181
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Arsenic 2.5911134558
MESH:D008113 Liver Neoplasms Arsenic 8.0116368122
MESH:D008113 Liver Neoplasms pirinixic acid 8.0120007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 8.0115276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.69598648 1399818 3712494 6587162
MESH:D008171 Lung Diseases sodium arsenite 3.3519095001
MESH:D008175 Lung Neoplasms Arsenic 2.7217306315 17976673 19168569
MESH:D008175 Lung Neoplasms sodium arsenite 2.7217306315 19931552 16712894 17077188 15276417
MESH:D008545 Melanoma sodium arsenite 2.0616487513 19082730
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Arsenic 4.2115371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms pirinixic acid 5.3517405874
MESH:D009369 Neoplasms sodium arsenite 5.3511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0220056578
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 13.196679447
MESH:D009436 Neural Tube Defects Arsenic 13.1916620997
MESH:D009436 Neural Tube Defects sodium arsenite 13.1912854658
MESH:D020078 Neurogenic Inflammation Arsenic 4.6817056641
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.684026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010051 Ovarian Neoplasms Arsenic 5.2717306315
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.2715276417 17306315
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3915371236 6392382 16905509
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011471 Prostatic Neoplasms Arsenic 2.6716140617
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.6716205645
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6716039940
MESH:D011507 Proteinuria Arsenic 4.3121343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012871 Skin Diseases Arsenic 2.8019834688 15952646 17938729 16759981 16702368 6392382 18709164 17050553 16353154 17453740 17548696
MESH:D012878 Skin Neoplasms Arsenic 6.3317976673 16251483 19538983 17050553 17029826 15504454
MESH:D012878 Skin Neoplasms sodium arsenite 6.3319524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0112854658
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.096582329 7505956 3712494 6587162 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.928074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.9219429237 11144890 18640142 15987713 17976673 19322015 17306315
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.9217306315 16712894 16452187 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0311813266
MESH:D014652 Vascular Diseases Arsenic 13.2117056641
MESH:D014652 Vascular Diseases sodium arsenite 13.2117056641
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38800
    • No data
    Releated disease ID Related disease Name
    PA445689Sleep Disorders
    Releated drug ID Related drug Name
    PA450626nicotine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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