AutismKB 2.0

Annotation Detail for ASPM


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Basic Information Top
Gene Symbol:ASPM ( ASP,Calmbp1,DKFZp686N06184,FLJ10517,FLJ10549,FLJ43117,MCPH5 )
Gene Full Name: asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
Band: 1q31.3
Quick LinksEntrez ID:259266; OMIM: 605481; Uniprot ID:ASPM_HUMAN; ENSEMBL ID: ENSG00000066279; HGNC ID: 19048
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
2022Liver cancer
No data
No data
Desease Name
Microcephaly, primary autosomal recessive, 5, with or without simplified gyral pattern
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of ASPM mRNAdecreases expression 20406850
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ASPM mRNAincreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ASPM proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in increased expression of ASPM mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ASPM mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ASPM mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ASPM mRNAdecreases expression 20382639
20018196
19150397
C006780 bisphenol A bisphenol A affects the expression of ASPM mRNAaffects expression 19490990
C006780 bisphenol A bisphenol A results in increased expression of ASPM mRNAincreases expression 16474171
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ASPM mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of ASPM mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of ASPM mRNAincreases expression 16474171
D019833 Genistein Genistein affects the expression of ASPM mRNAaffects expression 18847459
D019833 Genistein Genistein results in increased expression of ASPM mRNAincreases expression 16474171
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of ASPM mRNAincreases expression 20713471
D017239 Paclitaxel Paclitaxel results in increased expression of ASPM mRNAincreases expression 17374387
C006253 pirinixic acid pirinixic acid results in increased expression of ASPM mRNAincreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of ASPM mRNA]increases expression|increases reaction 17950772
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of ASPM mRNAincreases expression 16474171
D011374 Progesterone Progesterone results in increased expression of ASPM mRNAincreases expression 18070364
C017947 sodium arsenite sodium arsenite results in decreased expression of ASPM mRNAdecreases expression 17998272
D024505 Tocopherols Tocopherols results in increased expression of ASPM mRNAincreases expression 17056531
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of ASPM mRNAdecreases expression 17951470
D014750 Vincristine Vincristine results in increased expression of ASPM mRNAincreases expression 17374387
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 13.3411798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 13.3420464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 13.3411473722
MESH:D000230 Adenocarcinoma Genistein 13.3411473722
MESH:D000230 Adenocarcinoma Vincristine 13.3419825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.923712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.926695378
MESH:D000236 Adenoma Methylcholanthrene 10.9210545420 6695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4016434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8216712894 17306315
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4011922910
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.941440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.7216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7219483382
MESH:D001859 Bone Neoplasms Paclitaxel 4.4815867366
MESH:D001862 Bone Resorption bisphenol A 3.7811985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2617868700
MESH:D001930 Brain Injuries Progesterone 4.1715665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7217474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 3.7217123778
MESH:D001943 Breast Neoplasms Estradiol 3.7216675129 12948864 14630087 18497071 17289903 19861407 17018787 17261762
MESH:D001943 Breast Neoplasms Genistein 3.7217200150 16541309 16873071
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.7217474063
MESH:D001943 Breast Neoplasms Paclitaxel 3.7215136595 18323546 11325840 16273361 16115903 18234424 16244791 18223236
MESH:D001943 Breast Neoplasms Progesterone 3.7216175315 17614352 15562024
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2411589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6916050911 16011737 18705752 16124888 16192424 16227642 16097048 3786805 15721981 15700767 10355542 15673190
MESH:D002277 Carcinoma Methylcholanthrene 3.9010545420
MESH:D003528 Carcinoma, Adenoid Cystic marker/mechanism 16762588
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 19.6716705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 19.673581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 19.6721507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 19.6711135700 16217749 14691202 15553829 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.6718788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.6716924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.6716924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 19.6716313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 19.6717306315 16507464 15276417
MESH:D002278 Carcinoma in Situ bisphenol A 4.9017123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.857296757
MESH:D002292 Carcinoma, Renal Cell Vincristine 6.8516201981
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0412490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.5720419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.5718572023
MESH:D002294 Carcinoma, Squamous Cell Vincristine 7.576189445
MESH:D002318 Cardiovascular Diseases Genistein 3.2416332659
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 30.896135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 30.897505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 30.8920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 30.8912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 30.8918566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 30.8916192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 30.8919524636 20056578
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.0019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.0019486331
MESH:D002779 Cholestasis pirinixic acid 13.0019176532
MESH:D003110 Colonic Neoplasms Genistein 2.2717182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.5720501625
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.5718802399
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 3.5715531428
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0115213294
MESH:D003704 Dementia Polychlorinated Biphenyls 4.6216140633
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7211906362 18759878 14531868 12868966 8970840 2524372 11298694 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.413621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.4716647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.3319279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4117187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.0821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.0818692083 16192314 18289764 7440962 18648102 9328219 11289319 6679447 9653073 8291058 6482804 1440618 9022650
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.0810092053 3786805 2869522 16227642 15027814 3732212 11566570 17522070 19336974 7440962 6884620 7120509 7179309 21278145 19085960 10915739 9327722 16177239 15968718 6623471 4309450 15998439
MESH:D004487 Edema pirinixic acid 2.4012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.6917692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.5016402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.3111473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.3111473722
MESH:D004715 Endometriosis Progesterone 3.6916134523
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 13.593581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 13.5920426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 13.5912903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 13.5916530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 13.5916481741
MESH:D005234 Fatty Liver arsenic trioxide 18.0815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.0815959796 16045604 12795759 16239168 17595544 12631006 61145 19224547
MESH:D005234 Fatty Liver Cyclosporine 18.0819224547
MESH:D005234 Fatty Liver pirinixic acid 18.0820131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.946705139
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.8510962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 8.3818705752
MESH:D005355 Fibrosis Cyclosporine 8.3812639820 12168785
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1816904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Genistein 3.2016598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.957505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6120471113
MESH:D006333 Heart Failure pirinixic acid 2.4820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.946705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.9419900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 2.9116221962 18467677 19772884 19176532
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D006689 Hodgkin Disease sodium arsenite 7.6612676792
MESH:D006689 Hodgkin Disease Vincristine 7.6615147373 16135485 17606976 16794504
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8515034207
MESH:D006973 Hypertension Cyclosporine 2.0710903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3115869954
MESH:D007248 Infertility, Male sodium arsenite 2.9312646999 15346721
MESH:D007249 Inflammation Progesterone 2.5615869954
MESH:D007333 Insulin Resistance bisphenol A 11.9816393666
MESH:D007333 Insulin Resistance Estradiol 11.9816393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.9816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.949022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Cyclosporine 9.7618776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.7615618244
MESH:D007674 Kidney Diseases sodium arsenite 9.7620008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.1316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.136582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.1312371664
MESH:D007680 Kidney Neoplasms Estradiol 17.1315610895
MESH:D007938 Leukemia arsenic trioxide 6.2915070760
MESH:D007938 Leukemia Genistein 6.2917468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7117077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6819077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1216968895 16467208 17050201 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1617712046 15622746 16330433 12679006 17107899 12018890 9834237 15748426 11468182 16331271 12712474 17217047 19075265 15336539 16823087 17869043 17649720 16966277 15213294 16891316 11161223 16112521 19225113 19642359 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2716882451
MESH:D008080 Liposarcoma Paclitaxel 4.7417353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7617157831 16239168 21278145 16943688 11903743 16221502 17174718 11408273 17334410
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.8718263696 18277467 18251166 12546737 18420326 15730626 18376398 12649538 15818738 15673190 18339082 17557913 10355542 17481882 18156304 12898905 17525996 12632514 18279442 17823541 16097048 17869086 12445421 18472332 14716833 12666154 15362042 16136751 16192424 14748882 17708605 15338365 17976157 18412020 17761835 17805973 15959796 14716496 15876570 18210741 18395095 18472094 12586293 16248980 18429990 18395914 17721639 16015684 18418968 15057751 16027843 18166357 18205269 16116963 15123356 14620537 12667390 15893842 12632512 12445418 12741479 17900296 13678700 18054572 17714472 18705752 17640975 11481614 17766677 14724832 17631135 18481824 16011737 18317297 12958196 15052691 12609069 17698563 15996030 15931870 18187930 17922224 17944888 12389079 20821823 14512876 15925388 16638106 15370692 16033810 18006644 17565644 15650968
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.8717823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8715474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0616246199 16964402 15720792 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6114706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.417678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 21.4115890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms arsenic trioxide 21.4114682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.4121137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.4119294768
MESH:D008113 Liver Neoplasms pirinixic acid 21.4116377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 21.4116712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 27.456135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 27.456587162 3712494 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 27.458603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 27.4520377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 27.4515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 27.45598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 27.451423854
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2815213294
MESH:D008171 Lung Diseases sodium arsenite 3.1119095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.4314755239
MESH:D008175 Lung Neoplasms arsenic trioxide 8.4319825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.436695378 20869020 18520028 18569708 20135361 18816296 17053015 20064080 20464547
MESH:D008175 Lung Neoplasms Methylcholanthrene 8.4316337739 20970405 15390079 11893704 1399818 10545420 16271038 20512841 9230183 6695378 7750092 17909032 21163286
MESH:D008175 Lung Neoplasms sodium arsenite 8.4319931552 17306315 17077188 15276417 16712894
MESH:D008175 Lung Neoplasms Vincristine 8.436189445 19825857
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.0214749477
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.8816891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.8812929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.8811408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 13.8817927505
MESH:D020149 Manganese Poisoning Estradiol 4.4019453300
MESH:D008545 Melanoma Paclitaxel 3.5312025231 12040289 16342250
MESH:D008545 Melanoma sodium arsenite 3.5316487513 19082730
MESH:D018328 Melanoma, Amelanotic Vincristine 5.7015990972
MESH:D008654 Mesothelioma Tocopherols 4.0715878867
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
OMIM:608716 MICROCEPHALY, PRIMARY AUTOSOMAL RECESSIVE, 5 marker/mechanism
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D009101 Multiple Myeloma arsenic trioxide 7.2919417148 11468182 19549372 15949261 14977855
MESH:D009101 Multiple Myeloma Paclitaxel 7.2914749477
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0916882451 16105982
MESH:D009203 Myocardial Infarction Genistein 9.4417141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.4419151258
MESH:D009203 Myocardial Infarction Vincristine 9.4417284715
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.7716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.7717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.7716411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.787678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8716624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.843581430
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.8415867366
MESH:D009369 Neoplasms Benzo(a)pyrene 7.9511141357
MESH:D009369 Neoplasms pirinixic acid 7.9517405874
MESH:D009369 Neoplasms sodium arsenite 7.9511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5820056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2118481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 15.9716427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 15.9716427766 11399458
MESH:D009421 Nervous System Malformations Genistein 15.9716427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.806679447
MESH:D009436 Neural Tube Defects arsenic trioxide 11.8010525206
MESH:D009436 Neural Tube Defects sodium arsenite 11.8012854658
MESH:D017599 Neuroectodermal Tumors Vincristine 5.6212837982
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.626482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.943988306
MESH:D010014 Osteolysis Paclitaxel 4.8915867366
MESH:D010024 Osteoporosis Genistein 3.2019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0016169203
MESH:D010049 Ovarian Diseases bisphenol A 4.9011985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 18.5212452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 18.5219401270
MESH:D010051 Ovarian Neoplasms Genistein 18.5219005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 18.5211161223
MESH:D010051 Ovarian Neoplasms Progesterone 18.5216525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 18.5215276417 17306315
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.4915580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.407296757
MESH:D010235 Paraganglioma arsenic trioxide 4.0819927285
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3616702228
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.396228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Vincristine 4.5721297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.8710548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.2820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.2820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.9419131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.9416740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.9416740699
MESH:D011471 Prostatic Neoplasms Genistein 2.9415256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.9417136230 16729912 17172428 16356831
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.9415721890
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.9416039940
MESH:D011471 Prostatic Neoplasms Tocopherols 2.9412504091
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011629 Puberty, Precocious bisphenol A 4.7010548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.313692021
MESH:D012468 Salivary Gland Neoplasms marker/mechanism 16762588
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8716646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4818551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5819755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 5.5818572023 19524636
MESH:D013119 Spinal Cord Injuries Progesterone 4.1915862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7312854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3817007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3820155912 2093021
MESH:D013274 Stomach Neoplasms Paclitaxel 3.3818506536 18396642
MESH:D019966 Substance-Related Disorders bisphenol A 3.9016684133 16045194
MESH:D015173 Supratentorial Neoplasms Vincristine 5.7912837982
MESH:D024801 Tauopathies Paclitaxel 4.7316930453
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.931399818 6582329 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.9319014326
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8815213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.4416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 15.448074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.4411780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.4417053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.4411723127 16452187 16712894 17306315
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2310091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6911813266
MESH:D014591 Uterine Diseases bisphenol A 4.9314652134
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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