AutismKB 2.0

Annotation Detail for SOSTDC1


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Basic Information Top
Gene Symbol:SOSTDC1 ( DKFZp564D206,ECTODIN,USAG1 )
Gene Full Name: sclerostin domain containing 1
Band: 7p21.2
Quick LinksEntrez ID:25928; OMIM: 609675; Uniprot ID:SOSD1_HUMAN; ENSEMBL ID: ENSG00000171243; HGNC ID: 21748
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200123BMP receptor signaling
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Related Diseases/Disorders Top
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Desease Name
Response to statin therapy
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C105260 4-tert-octylphenol 4-tert-octylphenol results in decreased expression of SOSTDC1 mRNAdecreases expression 17011747
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of SOSTDC1 mRNAincreases expression 17011747
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SOSTDC1 mRNAaffects expression 16483693
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of SOSTDC1 mRNAdecreases expression 17011747
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of SOSTDC1 mRNAincreases expression 17011747
D004958 Estradiol Estradiol affects the expression of SOSTDC1 mRNAaffects expression 14699072
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SOSTDC1 mRNAdecreases expression 17557909
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SOSTDC1 mRNAaffects binding|decreases expression|increases activity 19710929
D013629 Tamoxifen Tamoxifen affects the expression of SOSTDC1 mRNAaffects expression 14699072
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Estradiol 4.4111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4114692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000686 Amyloidosis Diethylstilbestrol 4.8115469931
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9315324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 1.9317289903 12948864 17261762 16675129 17018787 14630087 19861407 18497071
MESH:D001943 Breast Neoplasms Tamoxifen 1.9316818667 17893378 18629630 18815881 18984771 15565566 20859285 20135344 19059307 19189210 18997820 19487384 17242785 19410462 20005174 21152245 19244106 19189212 19066611 19142967 19288272 17261762 19289846 19084267 16273361 20544844 20065188 19200415 18425577 16202921 18821012 19115204 18855134 17440819 19103187 19011961 11161223 21138602 17049068 15668708 18351453 20390343 19155303 19221464 16873071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.8416924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8416924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.8416924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4211677210 15861022 17681005 17333356 16919318 17110522 16105132
MESH:D002779 Cholestasis pirinixic acid 8.4219176532
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8916002989 12952375
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003928 Diabetic Nephropathies Estradiol 9.6819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.6819279558
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.0916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 13.4815700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 13.4819148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 13.4820544844 19155303 16202921 17893378
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.7415345470
MESH:D005234 Fatty Liver pirinixic acid 14.7419236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 14.7419224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 8.7216611131 16513791 16002989 15751030 16534752
MESH:D052776 Female Urogenital Diseases Tamoxifen 8.7216709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.3416452187
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3519772884 18467677 16221962 19176532
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.7914722030 12960047
MESH:D007021 Hypospadias Diethylstilbestrol 12.4716002989
MESH:D007021 Hypospadias Ethinyl Estradiol 12.4716569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.6815036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007333 Insulin Resistance Estradiol 7.7716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.7716306350
MESH:D007674 Kidney Diseases Estradiol 2.7215618244
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 13.8716762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 13.8715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 13.8718625569
MESH:D007859 Learning Disorders Diethylstilbestrol 4.4217184923
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5918564211
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.9815890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 7.9816377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 7.9816684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.5515166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6615700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.9616002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5317203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5311731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 14.1719453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.1719453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.9616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.9616411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Diethylstilbestrol 5.4415313581
MESH:D009369 Neoplasms pirinixic acid 5.4417405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.9211399458
MESH:D009421 Nervous System Malformations Estradiol 10.9211399458 16427766
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.6114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.0316977796 15687265
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.5117184923
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.5317136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.5316740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5315067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D013088 Spermatocele Diethylstilbestrol 22.9216709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 22.9216709447
MESH:D013088 Spermatocele Tamoxifen 22.9216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.5217306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.5217572228 16712894 8653321
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.3016175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.6114652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 10.5916690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.5914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7916513791 16002989
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8215869587 14671159
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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