AutismKB 2.0

Annotation Detail for GAMT


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Basic Information Top
Gene Symbol:GAMT ( PIG2,TP53I2 )
Gene Full Name: guanidinoacetate N-methyltransferase
Band: 19p13.3
Quick LinksEntrez ID:2593; OMIM: 601240; Uniprot ID:GAMT_HUMAN; ENSEMBL ID: ENSG00000130005; HGNC ID: 4136
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
GLYCGREAT-PWYglycine degradation (creatine biosynthesis)
Pathway IDPathway Name
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
hsa00260Glycine, serine and threonine metabolism
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500785Creatine metabolism
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GAMT mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of GAMT mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of GAMT mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of GAMT mRNAdecreases expression 19103213
D000638 Amiodarone Amiodarone affects the expression of GAMT mRNAaffects expression 19483382
D000641 Ammonia Ammonia results in increased expression of GAMT proteinincreases expression 20227315
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GAMT mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of GAMT mRNAaffects expression 19483382
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in decreased expression of GAMT mRNAdecreases expression 15912405
C032036 bromobenzene bromobenzene metabolite binds to GAMT proteinaffects binding 17305373
D002330 Carmustine Carmustine results in decreased expression of GAMT mRNAdecreases expression 15980968
D002994 Clofibrate Clofibrate affects the expression of GAMT mRNAaffects expression 19483382
D003401 Creatine GAMT protein results in increased chemical synthesis of Creatineincreases chemical synthesis 18428409
D003520 Cyclophosphamide GAMT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D016572 Cyclosporine Cyclosporine results in decreased expression of GAMT mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of GAMT mRNAincreases expression 18042831
D004317 Doxorubicin GAMT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D005001 Ethionine Ethionine affects the expression of GAMT mRNAaffects expression 19483382
D005472 Fluorouracil Fluorouracil results in increased expression of GAMT proteinincreases expression 15352031
D005472 Fluorouracil GAMT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D005472 Fluorouracil GAMT protein affects the susceptibility to Fluorouracilaffects response to substance 15352031
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of GAMT mRNA]affects reaction|decreases expression 15016801
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of GAMT mRNAaffects cotreatment|increases expression 17183730
D008727 Methotrexate GAMT protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D009853 Omeprazole Omeprazole affects the expression of GAMT mRNAaffects expression 19483382
D017239 Paclitaxel GAMT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
C041786 palm oil palm oil results in increased expression of GAMT mRNAincreases expression 18042831
D010634 Phenobarbital Phenobarbital results in increased expression of GAMT mRNAincreases expression 12082028
D010656 Phenylephrine Phenylephrine results in decreased expression of GAMT mRNAdecreases expression 18158353
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GAMT mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of GAMT mRNAdecreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of GAMT mRNA]decreases expression|increases reaction 20059764
C006253 pirinixic acid pirinixic acid affects the expression of GAMT mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of GAMT mRNAaffects expression 19483382
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GAMT mRNAdecreases expression 16960034
D013853 Thioacetamide Thioacetamide affects the expression of GAMT mRNAaffects expression 19483382
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of GAMT mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 18.0612039119
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 18.066195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 18.0615322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 18.068875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6819490988
MESH:D000138 Acidosis Ammonium Chloride 3.2818287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.8618653653
MESH:D000230 Adenocarcinoma Doxorubicin 4.3717418594
MESH:D000230 Adenocarcinoma Fluorouracil 4.3717638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.593712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.6617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.6616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.6616835633
MESH:D000419 Albuminuria Doxorubicin 4.2821441931
MESH:D000550 Amblyopia Valproic Acid 4.9517688650
MESH:D000592 Amino Acid Metabolism, Inborn Errors marker/mechanism 15651030
MESH:D000740 Anemia Fluorouracil 7.8816511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.8811748828
MESH:D000799 Angioedema Acetaminophen 3.5610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.3517497229
MESH:D001145 Arrhythmias, Cardiac Amiodarone 8.3418057881 18218290 20041841
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 8.3417460149
MESH:D001161 Arteriosclerosis Cyclophosphamide 9.4215014928
MESH:D001161 Arteriosclerosis Dietary Fats 9.4215238619
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.0317286800
MESH:D001281 Atrial Fibrillation Amiodarone 3.7019698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 2.4018445737
MESH:D001321 Autistic Disorder Creatine 2.4016818868
MESH:D001321 Autistic Disorder Valproic Acid 2.4018316065 17688650 17507914 19460635 20603192 18775368 18177632 18940202 16609825 18396377 15238991 19232924 18985861 17157402 18558336
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.7311289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 2.9417594078 20046352
MESH:D001778 Blood Coagulation Disorders Amiodarone 53.3819483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 53.3819483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 53.3819483382
MESH:D001778 Blood Coagulation Disorders Ethionine 53.3819483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 53.3819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 53.3819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 53.3819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 53.3812125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 53.3819483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.438888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4214601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.3115867366
MESH:D001919 Bradycardia Phenylephrine 4.2615306635
MESH:D001929 Brain Edema Ammonia 5.9919393034 11481608 20217200
MESH:D001932 Brain Neoplasms Carmustine 8.3316187019
MESH:D001932 Brain Neoplasms Doxorubicin 8.3317150277
MESH:D001943 Breast Neoplasms Cyclophosphamide 3.5817020986 17388661 15093573 18234424 11325840 16978400 15136595 18323546 12006526
MESH:D001943 Breast Neoplasms Dietary Fats 3.5820435547
MESH:D001943 Breast Neoplasms Doxorubicin 3.5818234424 16264153 15634643 16096432 15692762 17426702 15668708 15136595 16322301 19526202 16935488 15939500 15993339 15567936 16595493 18695136 16826403 17983394 15994142 18628466 18382427 16115903 17369602 11325840
MESH:D001943 Breast Neoplasms Fluorouracil 3.5818608205 16110121 16557594 19217205 18357371 15136595 16595493
MESH:D001943 Breast Neoplasms Methotrexate 3.5816978400
MESH:D001943 Breast Neoplasms Paclitaxel 3.5816115903 16244791 11325840 16273361 18234424 15136595 18223236 18323546
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.5820435547
MESH:D002276 Carcinoid Tumor Doxorubicin 11.4116051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.4116051944
MESH:D002277 Carcinoma Fluorouracil 7.4617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.4616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 21.9416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 21.947296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 21.943084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 21.941701930
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 21.9419701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 21.9416234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 21.9416332177 16799960 17045692 17971768 18930000 17088986
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 21.9416313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 21.941701930 6705139 20007298 17173139 20935162
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 21.9417997003
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.6116152834
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 14.307296757
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 14.3016201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 14.3016201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 14.3018695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.576189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.5716757204 17066447 18986760 16280240
MESH:D006332 Cardiomegaly Phenylephrine 6.3717124262 16170337 11754973 17287366 11179087 15728586
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3718850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3516612575 15476868 17974986 16364871 17924179 17329180 17382496 17308081 16455267 17131338 16278810 18627295 16242529 16651473 17007740 17519947 15792986 17351982 15811867 15505089 16952015 17928571 16269455 16109756 16731534
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.6515710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 5.6516243910 17334414
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8018974383
MESH:D002386 Cataract Acetaminophen 2.4210977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.147505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 10.141399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.1412371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.984080065
MESH:D002637 Chest Pain Omeprazole 4.8215447763
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6120734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7716835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.7718291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.2019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.2019486331
MESH:D002779 Cholestasis pirinixic acid 12.2019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9916354765 15340226 12621046 8697196 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 2.1917287894 16340194 17018589 15001691 17016597 18772588 17725105 17172411 16510598 17169374
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.4018259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.4017255274 16303861 15289873 17594712 18288408 17695437 14970324 16282729 18448328 15148649 18949393 18802399 17094418 18383874 16391804 16331619 20501625 17401013 18509181 17454858 17016601 16524972
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.4018802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8317141729 14669216
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.699562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6915322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.698888407 16575769 17688650
MESH:C535598 Creatine deficiency, X-linked Creatine 7.1512210795
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7418551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.0019747007
MESH:D003556 Cystitis Cyclophosphamide 4.7018093676 18372110 15643279 15276878 16413132 10498854 12388444 16614059 11948286 12913760 18710439 16989017 18483878 17010015 17979934 18433785 10700343 18295254 12161096 16651033
MESH:D007644 Darier Disease Fluorouracil 4.5116733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.6518759878 2524372 12868966 8970840 11298694 8156756 14531868 11906362
MESH:D017449 Dermatitis, Allergic Contact Ammonia 6.6516823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.232952479 3621924
MESH:D003882 Dermatomyositis Methotrexate 4.8620191521
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.8410990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1318772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6017107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 24.2221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 24.2216192314 7440962 6679447 9022650 18692083 8291058 18289764 9653073 1440618 18648102 11289319 6482804 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 24.2211743745 18071297 12153990 11461765 11739529 11834606 18713872 17906064 14550746 16227642 10663392 11287661 15619225 19085960 12594235 16081117 12540782 14986274 19164858 12705907 17562736 16177239 10774834 12958197 19420014 10915739 19370779 15968718 16485898 17522070 12392966 16109766 19923254 11421492 16393943 14725611 2444490 16781746 11529661 19416960 19739265
MESH:D056486 Drug-Induced Liver Injury Amiodarone 24.2215265979 18218290
MESH:D056486 Drug-Induced Liver Injury bromobenzene 24.2212628495 10092053
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 24.2217416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 24.2220420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 24.2212963478
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 24.2219641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8119426721
MESH:D004362 Drug Toxicity Doxorubicin 7.4318602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.4311462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.0617151854 16613094 15991576 21218061
MESH:D050171 Dyslipidemias Clofibrate 8.1616707586
MESH:D050171 Dyslipidemias Dietary Fats 8.1618367378
MESH:D004421 Dystonia Phenobarbital 9.581851702
MESH:D004421 Dystonia Valproic Acid 9.581851702
MESH:D004487 Edema pirinixic acid 5.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.7212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6215322242 18230668 16714409
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.2717359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.789294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8718037988
MESH:D004802 Eosinophilia Cyclophosphamide 3.9411006010
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 9.883659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 9.8817275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.033922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 9.033922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.1920417680
MESH:D004827 Epilepsy Valproic Acid 6.1918234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 8.096401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.096254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.397750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.397750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.553659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 9.553659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.903581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.9016481741 15173087 16785472 16337965 17638652
MESH:D004938 Esophageal Neoplasms Paclitaxel 6.9016481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005218 Fat Necrosis Thioacetamide 5.4416456712
MESH:D005234 Fatty Liver Amiodarone 27.4714986274
MESH:D005234 Fatty Liver Clofibrate 27.4719224547
MESH:D005234 Fatty Liver Cyclosporine 27.4719224547
MESH:D005234 Fatty Liver Dietary Fats 27.4718296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver pirinixic acid 27.4719236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 27.4714986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.868888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.736705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.3119069698
MESH:D005355 Fibrosis Cyclosporine 13.1312168785 12639820
MESH:D005355 Fibrosis Dietary Fats 13.1318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.1320067830
MESH:D005756 Gastritis Acetaminophen 3.3916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.948708960
MESH:D005909 Glioblastoma Carmustine 6.9816187019
MESH:D005909 Glioblastoma Doxorubicin 6.9817150277
MESH:D005910 Glioma Fluorouracil 2.7616145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.2311389073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.787505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 11.2511014644 15172196 16376943
MESH:D006086 Graft vs Host Disease Methotrexate 11.2516518429
MESH:C537622 Guanidinoacetate methyltransferase deficiency marker/mechanism 15651030
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.3015692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.3015162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1811294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.2916244371 16879835 12587719 14766674 18674790 16244372 16330681 16495754 16707910 17875725 16144979 18006777 17888722
MESH:D006333 Heart Failure Doxorubicin 6.4817481944
MESH:D006333 Heart Failure pirinixic acid 6.4820558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6515692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1415720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.0211918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006501 Hepatic Encephalopathy Ammonia 10.5712420312 16338762 20549931
MESH:D006501 Hepatic Encephalopathy Thioacetamide 10.5718665440 17276928 15929193
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.2514986274
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.576705139
MESH:D006505 Hepatitis Thioacetamide 8.5716456712
MESH:D006529 Hepatomegaly Amiodarone 18.4215265979
MESH:D006529 Hepatomegaly Phenobarbital 18.4216109766
MESH:D006529 Hepatomegaly pirinixic acid 18.4219772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 18.4215340226 16120746 12621046
MESH:D006689 Hodgkin Disease Cyclophosphamide 6.9416135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 6.9418501091 15147373 17606976
MESH:D006849 Hydrocephalus Valproic Acid 4.5917688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.768697196 16354765 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.4816870215
MESH:D006937 Hypercholesterolemia Amiodarone 8.348137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 8.3421332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3621332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6715034207
MESH:D006973 Hypertension Cyclosporine 7.9710903974
MESH:D006973 Hypertension Phenylephrine 7.9712717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9718670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.3516612254
MESH:D006984 Hypertrophy Phenylephrine 4.3012791704 18502941
MESH:D007037 Hypothyroidism Amiodarone 10.7018020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 10.708137927 18031379
MESH:D007154 Immune System Diseases Cyclophosphamide 5.0516076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.447193160 16517039
MESH:D007249 Inflammation Dietary Fats 4.4420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.4412200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 6.6518457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 6.6516306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.738074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1615604871
MESH:D007674 Kidney Diseases Acetaminophen 9.1112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.118314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 9.1115369732 15699352 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.9016707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 15.9116705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 15.916582329
MESH:D007680 Kidney Neoplasms Cyclosporine 15.9112371664
MESH:D007680 Kidney Neoplasms Fluorouracil 15.9116985049
MESH:D007805 Language Development Disorders Methotrexate 4.849562676
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.8719248655
MESH:D007938 Leukemia Cyclophosphamide 3.3510602166
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8716085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.3817658394 17802794 18172266 17008537 17296974 18587576
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.8810373061
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1016294345 17596541
MESH:D007970 Leukopenia Cyclophosphamide 4.6910052129 11830472
MESH:D008064 Lipidoses Amiodarone 3.3117567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.5617353645
MESH:D008103 Liver Cirrhosis Dietary Fats 10.2518296743
MESH:D008103 Liver Cirrhosis Methotrexate 10.2514986274
MESH:D008103 Liver Cirrhosis Phenobarbital 10.2521047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0215034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.6716595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.6715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.6712878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.6712891558 16248980 12679928 18458672 16511523 17355460 18395095 16098781 12175628 15095483 15465738 18380797 15288473 15078482 15075984 18031379 12557150 15334695 17127702 18416461 18606216 16343077 18263696 16126171 12085344 15316131 18615449 15716488 16489207 15288472 15362042 11481614 17050028 17629604 14739098 12531686 10677585 11682029 16097051 11172339 17292413 18032466 15474484 18295389 15158331
MESH:D008107 Liver Diseases Acetaminophen 6.1119460945 11587558 19784758 16610002 19014921 12587719 12969438 16611625
MESH:D008107 Liver Diseases Phenobarbital 6.1119363144
MESH:D008107 Liver Diseases Thioacetamide 6.1116337175 18374380 15158337
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8317185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 8.8315633222 12479984 17276928 15313186
MESH:D008113 Liver Neoplasms Fluorouracil 9.7817045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms Phenobarbital 9.7819073162 8742319 19812893 15975961 19482888 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 9.7820007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.7816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 12.70598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 12.7016842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 12.7017172636 6150874 1399818 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.7012151625
MESH:D008133 Long QT Syndrome Amiodarone 3.3717391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.1912587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 17.5018516814
MESH:D017563 Lung Diseases, Interstitial Methotrexate 17.5018516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 17.5017228818
MESH:D008175 Lung Neoplasms Doxorubicin 3.2717418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 3.2715246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2711884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5115086387
MESH:D008223 Lymphoma Cyclophosphamide 11.6112854902
MESH:D008223 Lymphoma Doxorubicin 11.6116098063
MESH:D008223 Lymphoma Methotrexate 11.6117352296
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.3416675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 13.3711911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 13.3717654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 13.3714749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2915621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 2.8615458769
MESH:D008545 Melanoma Carmustine 5.0412393984
MESH:D008545 Melanoma Doxorubicin 5.0416827129
MESH:D008545 Melanoma Paclitaxel 5.0412040289 12025231 16342250
MESH:D008546 Melanoma, Experimental Acetaminophen 9.9219513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.9216388313
MESH:D008607 Mental Retardation marker/mechanism 15651030
MESH:D008654 Mesothelioma Doxorubicin 2.9517638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5016801185
MESH:D008881 Migraine Disorders Valproic Acid 2.9918803445 18765137
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2515792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4216757204 18986760
MESH:D052016 Mucositis Doxorubicin 11.5817415656
MESH:D052016 Mucositis Methotrexate 11.5817488658
MESH:D009101 Multiple Myeloma Paclitaxel 3.4914749477
MESH:D009135 Muscular Diseases pirinixic acid 3.2316239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.788888407
MESH:D009181 Mycoses Amiodarone 4.6212754197 17974566
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0017596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.3215857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.3219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2017484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5818551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.943581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.9418259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 8.9415867366
MESH:D009369 Neoplasms Cyclophosphamide 7.5418854779
MESH:D009369 Neoplasms Fluorouracil 7.5418239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 7.5417405874
MESH:D009401 Nephrosis Doxorubicin 4.4916899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.5219348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.5216889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.656679447
MESH:D009436 Neural Tube Defects Valproic Acid 6.6516359493 8888407
MESH:D009447 Neuroblastoma Cyclophosphamide 6.7315176712 8761367 16115947
MESH:D009447 Neuroblastoma Doxorubicin 6.7315555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6518514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.6112837982 8761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2516436463
MESH:D009503 Neutropenia Cyclophosphamide 4.078291058
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.669802331
MESH:D009765 Obesity Dietary Fats 4.1916723640 21332399 18457598 18674790 20518802 17217161 20132043 19632207 11836018
MESH:D009765 Obesity pirinixic acid 4.1920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.0816049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.086482804 4026338
MESH:D009845 Oligospermia Cyclophosphamide 4.4316517039
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.733988306
MESH:D010014 Osteolysis Paclitaxel 4.7015867366
MESH:D010018 Osteomalacia Phenobarbital 4.0817016548
MESH:D012516 Osteosarcoma Doxorubicin 3.8915930896
MESH:D010051 Ovarian Neoplasms Paclitaxel 2.9011161223
MESH:D010146 Pain Acetaminophen 6.1216870215
MESH:D010146 Pain Cyclophosphamide 6.1218093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 8.1411332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.1415113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.1416965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.217296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.196228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8717638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.1912371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.192563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.6521297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.5311399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.5320603192
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.2217136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.2218437689 16868541 15897917 15749863 16729912 16888761
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.2219082440 18626508
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.2217172428 17136230 16356831 16729912
MESH:D019310 Pseudolymphoma Phenobarbital 11.2412752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.2412752131 11422049
MESH:D011565 Psoriasis Cyclosporine 5.5816882103
MESH:D011565 Psoriasis Methotrexate 5.5817410198
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.6112832656 12490602 11597910
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.6116636934
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7815538739 16160472 18286688 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 9.5817922066
MESH:D051437 Renal Insufficiency Methotrexate 9.5817352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.173692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.9219155313
MESH:D012509 Sarcoma Doxorubicin 3.7517710206 15625365 15675481 16767912 18313854 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.9814601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5117846226
MESH:D012559 Schizophrenia Valproic Acid 2.0315737665 19110320
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.5616636934
MESH:D012640 Seizures marker/mechanism 15651030
MESH:D012640 Seizures 2,4-dinitrotoluene 8.7518551238
MESH:D012640 Seizures Phenobarbital 8.753137016 4039156 16876388 11442880
MESH:D012640 Seizures Valproic Acid 8.7516876388 15475178 14763951 3137016 1511512 17978042 11044598 11738929
MESH:D003294 Seizures, Febrile Phenobarbital 4.546407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8018724381
MESH:D012852 Sinusitis Phenylephrine 4.427327846
MESH:D012878 Skin Neoplasms Doxorubicin 5.2515692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2516192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2916767912 17203757 15625365
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.2316517039
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5719490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2612833885
MESH:D013272 Stomach Diseases Omeprazole 4.3318545984
MESH:D013274 Stomach Neoplasms Fluorouracil 2.6717498489 18567086 16951190 15786421 19084572 16424979 19015929 18396642 17172411 17522103
MESH:D013274 Stomach Neoplasms Paclitaxel 2.6718506536 18396642
MESH:D013276 Stomach Ulcer Amiodarone 6.7618087811
MESH:D013276 Stomach Ulcer Omeprazole 6.7616755016 18237397 17977527 10750652 15991576 11906479
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.7812837982
MESH:D013576 Syndactyly Methotrexate 4.779562676
MESH:D013610 Tachycardia Amiodarone 4.0211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9219225199
MESH:D024801 Tauopathies Paclitaxel 4.5316930453
MESH:D013959 Thyroid Diseases Amiodarone 11.1019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.1012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 15.421399818 6582329 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 15.4216010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.421399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 15.4215710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.5918020914 19584973
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7516280240
MESH:D016171 Torsades de Pointes Amiodarone 3.9111989578 17467628
MESH:D014178 Translocation, Genetic Valproic Acid 4.9517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.243119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.0416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.048074119
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 11.0414692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.0417653716
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.378888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0410091137
MESH:D014581 Urticaria Acetaminophen 2.7210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.6416803524
MESH:D014605 Uveitis Cyclosporine 3.701336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9517678736 16364871 17334414 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D015430 Weight Gain Dietary Fats 3.5016723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1617120751
Pathway ID Pathway Name
KEGG:00330 Arginine and proline metabolism
KEGG:00260 Glycine, serine and threonine metabolism
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28549
    • Releated gene ID Related gene Name
    PA30729MECP2
    No data
    Releated drug ID Related drug Name
    PA449789glycine
    PA448478l-arginine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00148 product of Creatine Dietary supplement;Micronutrient
    DB00536 - Guanidine Parasympathomimetics
    DB01752 - S-Adenosyl-L-Homocysteine
    DB02751 - N-[Amino(Imino)Methyl]Glycine Affinity Labels
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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