AutismKB 2.0

Annotation Detail for SIN3A


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Basic Information Top
Gene Symbol:SIN3A ( DKFZp434K2235,FLJ90319,KIAA0700 )
Gene Full Name: SIN3 homolog A, transcription regulator (yeast)
Band: 15q24.2
Quick LinksEntrez ID:25942; OMIM: 607776; Uniprot ID:SIN3A_HUMAN; ENSEMBL ID: ENSG00000169375; HGNC ID: 19353
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200070Signaling events mediated by HDAC Class I
200002Regulation of nuclear SMAD2/3 signaling
200130C-MYB transcription factor network
200072Regulation of Telomerase
200147Hedgehog signaling events mediated by Gli proteins
Pathway IDPathway Name
P00029Huntington disease
P00059p53 pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2066Lung cancer
2118Adenovirus infection
Desease Name
height
DEVELOPMENTAL
Desease Name
Height
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SIN3A mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of SIN3A mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SIN3A mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SIN3A mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SIN3A mRNAdecreases expression 19150397
C014347 decitabine decitabine inhibits the reaction [SIN3A protein binds to ABCG2 promoter]affects binding|decreases reaction 16954373
D004958 Estradiol Estradiol promotes the reaction [SIN3A protein binds to ESR1 promoter]affects binding|increases reaction 19620290
D014212 Tretinoin Tretinoin inhibits the reaction [SIN3A protein binds to RARA protein]affects binding|decreases reaction 16782888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.347525203
MESH:D000230 Adenocarcinoma Estradiol 2.1511473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4611289319 1440618
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8916206674 16197459
MESH:D001943 Breast Neoplasms decitabine 1.9418320071 19208741
MESH:D001943 Breast Neoplasms Estradiol 1.9417289903 19861407 12948864 16675129 14630087 18497071 17018787 17261762
MESH:D001943 Breast Neoplasms Tretinoin 1.9416166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.853581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.853084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.851917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.9919215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9916096774 16051514
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 13.2414694615
MESH:D002386 Cataract Acetaminophen 13.2410977129
MESH:D002386 Cataract Tretinoin 13.2417460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.267505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.2620889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.2618566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.359022650 19486331
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.4115095906
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 9142499 14991402 9211117 9664655 9125849 17551590 8800419 16925845 9224671
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.152524372 12868966 11298694 8156756 8970840 11906362 18759878 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.793621924 2952479
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.6616192314 18692083 18648102 9328219 1440618 11289319 8291058 7440962 9653073 6679447 6482804 9022650 18289764
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.6621346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6612153990 16081117 10663392 11421492 19164858 17522070 11743745 16177239 18071297 19085960 12540782 16781746 12594235 14725611 14550746 19370779 17906064 12958197 19923254 10774834 10915739 12392966 11287661 16485898 11739529 12705907 19420014 17562736 18713872 15968718 11529661 14986274 11461765 19416960 19739265 2444490 16109766 15619225 16227642 11834606 16393943
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.5619294695
MESH:D016889 Endometrial Neoplasms Estradiol 7.9811473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 7.9816569247
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.583581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5820426865
MESH:D005124 Eye Abnormalities Tretinoin 3.7816938888 9664655
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005355 Fibrosis Tretinoin 3.8717994277
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006258 Head and Neck Neoplasms decitabine 8.4219215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.4216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0214991402 9664655
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006930 Hyperalgesia Acetaminophen 8.3716870215
MESH:D006930 Hyperalgesia Tretinoin 8.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D007248 Infertility, Male decitabine 3.3817581917
MESH:D007333 Insulin Resistance Estradiol 3.1316393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.469022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 4.1815992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 6.3715629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.3715618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.156582329
MESH:D007680 Kidney Neoplasms Estradiol 8.1515610895
MESH:D007938 Leukemia decitabine 6.8318980019 19235587
MESH:D007938 Leukemia Tretinoin 6.8317143497
MESH:D007951 Leukemia, Myeloid decitabine 10.5217236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 10.5216932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.1118206229 18460780 19387464 19010910 18704418 17679729
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.1116294345 19850784 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9118055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3217712046 17301526 16891316 16331271 19035177 16766008 17107899 17368321 9834237 15748426 19642359 19029980 17649720 19225113 19075265 16823087 17361223 17294898 17217047 16788101 17339181 12679006 16140955 17506722 16935935
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.359327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5318397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6816610002 16611625 19784758 19014921 11587558 19460945 12587719 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.691399818 598648 6587162 3712494
MESH:D008223 Lymphoma decitabine 3.6119470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7211408345 11807958 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma decitabine 3.5417785578 16505122
MESH:D008545 Melanoma Tretinoin 3.5416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D009101 Multiple Myeloma decitabine 3.5418172295
MESH:D009190 Myelodysplastic Syndromes decitabine 7.9619157545 16882708 18608210 19010910
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.9617596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms decitabine 5.5919470736 19116145 17925555
MESH:D009369 Neoplasms Tretinoin 5.5916946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 10.7911399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.799125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.806679447
MESH:D009436 Neural Tube Defects Tretinoin 7.809142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 10.024026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 10.0214694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010051 Ovarian Neoplasms decitabine 8.3319259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 8.3319401270
MESH:D010051 Ovarian Neoplasms Tretinoin 8.3316936753
MESH:D010146 Pain Acetaminophen 7.3716870215
MESH:D010146 Pain Tretinoin 7.3716870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.6519294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6515976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D055728 Primary Myelofibrosis decitabine 5.0917616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0416740699
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012208 Rhabdomyosarcoma decitabine 11.9819155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.9816116481 16283617
MESH:D012878 Skin Neoplasms Tretinoin 2.7216467112
MESH:D013274 Stomach Neoplasms decitabine 2.6019037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.6017261132
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 13.253712494 6582329 7505956 6587162 1399818
MESH:D013964 Thyroid Neoplasms decitabine 13.2517967635
MESH:D013964 Thyroid Neoplasms Tretinoin 13.2517045167 16026305
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.478074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.4717616700 19087683
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014604 Uveal Neoplasms decitabine 14.3517785578
MESH:D014604 Uveal Neoplasms Tretinoin 14.3516752155
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:05016 Huntington's disease
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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