AutismKB 2.0

Annotation Detail for PVRL3


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Basic Information Top
Gene Symbol:PVRL3 ( CD113,CDw113,DKFZp566B0846,FLJ90624,PPR3,PRR3,PVRR3,nectin-3 )
Gene Full Name: poliovirus receptor-related 3
Band: 3q13
Quick LinksEntrez ID:25945; OMIM: 607147; Uniprot ID:PVRL3_HUMAN; ENSEMBL ID: ENSG00000177707; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04520Adherens junction
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Cell junction organization
Pathway IDPathway Name
200053Nectin adhesion pathway
No data
Pathway IDPathway Name
500121Nectin/Necl trans heterodimerization
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PVRL3 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of PVRL3 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PVRL3 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PVRL3 mRNAaffects expression 17484886
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PVRL3 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PVRL3 mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PVRL3 mRNAincreases expression 17942748
C006253 pirinixic acid pirinixic acid results in decreased expression of PVRL3 mRNAdecreases expression 18445702
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PVRL3 mRNAdecreases expression 19933214
C025643 vinclozolin vinclozolin affects the expression of PVRL3 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma Diethylnitrosamine 2.9410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 18.7318056438 16434500 19061943 19052882 17162532 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.7316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.7316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9517474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9918705752 10355542 16050911 15673190 3786805 16227642 16011737 15721981 16097048 15700767 16192424 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.663084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6617162532 18788625 20512989 20084675 18691550 19052882 19107877 20214788 20007298 17761372 11831363 19335982 16328049 19701751 18978308 19519916 19418558 19394651 20101231 16878318 16540662 18785209 19383236 17428255 16779866 16569478 19822196 17055752 20514400 18393292 18056438 16935385 10737359 16807293 20727157 3084413 18971187 19171122 21159647 17138121 16502159 10672840 18494052 18210153 16830150 19539802 20432363 17978847 16698587 20935162 18665156 17173139 16681979 16288022 20524982 19919837 3581430 19208518 18506893
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0620889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.0617174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.8419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.8416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1716919318 17333356 11677210 17110522 17681005 15861022 16105132
MESH:D002779 Cholestasis pirinixic acid 8.1719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1616354765 8697196 15340226 15668235 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3417107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3319923254 17522070 2444490 17906064 16485898 11743745 15968718 16227642 12392966 12705907 16393943 14986274 15619225 16781746 16081117 11421492 12594235 11461765 17562736 12958197 18713872 11529661 19164858 14550746 16177239 14725611 12153990 18071297 19420014 19739265 10774834 12540782 19370779 19416960 10663392 10915739 16109766 11739529 19085960 11834606 11287661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.336884620 19085960 10092053 4309450 15998439 16227642 2869522 10915739 15027814 3786805 11566570 16177239 7179309 7120509 6623471 3732212 21278145 7440962 17522070 9327722 19336974 15968718
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.3319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.2417595544 16239168 15959796 61145 12795759 16045604 19224547 12631006
MESH:D005234 Fatty Liver Diethylnitrosamine 20.2420387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2415345470
MESH:D005234 Fatty Liver pirinixic acid 20.2420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.3318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3320067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 8.9919772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.9916120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 18606429 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0317937319
MESH:D007248 Infertility, Male vinclozolin 7.0316467254
MESH:D007249 Inflammation Diethylnitrosamine 5.1718785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1712200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9011408273 17334410 16221502 17157831 16943688 17174718 16239168 21278145 11903743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9020032147 18407596 18665156 18522880 19638242
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4816192424 12649538 16033810 17944888 17714472 18006644 15876570 12445418 17900296 15057751 16011737 18054572 13678700 15925388 17640975 17698563 14716833 14716496 12445421 18395914 16027843 17922224 18420326 15931870 15996030 12666154 12898905 14620537 12586293 17708605 17721639 16015684 18339082 17565644 18251166 18317297 18187930 18412020 17766677 14512876 18156304 12632514 17557913 16116963 15959796 12389079 17525996 17823541 12609069 17481882 15362042 11481614 18263696 18481824 17976157 14724832 12741479 17761835 12546737 17869086 12632512 18472332 15818738 18166357 18395095 15370692 16097048 15730626 18376398 16638106 18205269 16136751 18418968 14748882 12667390 15673190 15123356 15650968 18279442 17805973 15052691 18472094 18429990 20821823 17631135 18277467 12958196 15893842 10355542 18210741 18705752 15338365 16248980
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4812878042
MESH:D008107 Liver Diseases Acetaminophen 6.7012969438 12587719 19784758 16611625 19460945 11587558 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7016246199 15720792 15830285 16964402 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7017034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.8719294768
MESH:D008113 Liver Neoplasms Clofibric Acid 14.8717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.8719551842 21047994 19850985 19256749 20434301 21278145 19427195 19254457 20583210 9163691 19073162 15175105 18978307 19499222 19642983 19638242 16942905 20492335 15885732 19812893 2422723 10737359 19294768 18648771 20501860 19426721 19090486 20452335 2862719 19690152 19255062 19833225 21167192 18644402 19996281 18977376 20118626 12112319 21071580 20101389 20405173 20137499 12771043 18754104
MESH:D008113 Liver Neoplasms pirinixic acid 14.8715890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.8716984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.4018282651 16267830 19519916 18093689 9362446 18544905 19126423 19539802 2563599 18164116 18253720 18079962 21159647 19009564 17174075 17942915 18308698 3124819 16842330 18775883 19004024 17854601
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4012151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.3020970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3011884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.623581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.6720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4716540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.702563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2911222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.2918042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.117505956
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:20676 Cell junction organization
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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