AutismKB 2.0

Annotation Detail for GANC


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Basic Information Top
Gene Symbol:GANC ( MGC138256 )
Gene Full Name: glucosidase, alpha; neutral C
Band: 15q15.1
Quick LinksEntrez ID:2595; OMIM: 104180; Uniprot ID:GANC_HUMAN; ENSEMBL ID: ENSG00000214013; HGNC ID: 4139
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-842starch degradation
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00052Galactose metabolism
hsa00500Starch and sucrose metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2204Hemolytic anemia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of GANC mRNAaffects cotreatment|decreases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of GANC mRNAaffects cotreatment|decreases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of GANC mRNAaffects cotreatment|decreases expression 16931933
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of GANC mRNAaffects cotreatment|decreases expression 16931933
C006253 pirinixic acid pirinixic acid results in increased expression of GANC mRNAincreases expression 18301758
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of GANC mRNAaffects cotreatment|decreases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of GANC mRNAaffects cotreatment|decreases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of GANC mRNAaffects cotreatment|decreases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of GANC mRNAaffects cotreatment|decreases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.319612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D004362 Drug Toxicity Lamivudine 9.6715040536
MESH:D004362 Drug Toxicity Zidovudine 9.6715040536
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D005234 Fatty Liver pirinixic acid 9.2120131406 19236843
MESH:D005234 Fatty Liver Zidovudine 9.2118299183
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006402 Hematologic Diseases Zidovudine 5.1212579204
MESH:D006509 Hepatitis B Lamivudine 5.4717703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.4715274664 16476009 15309715 15631357 12044531
MESH:D006529 Hepatomegaly pirinixic acid 3.4818467677 16221962 19176532 19772884
MESH:D015658 HIV Infections Indinavir 16.8811141242 15388451 11363243
MESH:D015658 HIV Infections Lamivudine 16.889296927 11141242 17530837 20032539
MESH:D015658 HIV Infections Saquinavir 16.8815388451 11141242
MESH:D015658 HIV Infections Zidovudine 16.8811363243 17358032 11698656 11141242 20032539
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007680 Kidney Neoplasms Zidovudine 4.0912579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.7920370541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9220007298 15890375 16377806
MESH:D008175 Lung Neoplasms Zidovudine 2.4918800350
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.4517358032
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009164 Mycobacterium Infections Indinavir 6.0221442799
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012206 Rhabdomyolysis Lamivudine 6.089296927
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D014625 Vaginal Neoplasms Zidovudine 5.2412579204
Pathway ID Pathway Name
KEGG:00052 Galactose metabolism
KEGG:01100 Metabolic pathways
KEGG:00500 Starch and sucrose metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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