AutismKB 2.0

Annotation Detail for GAP43


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Basic Information Top
Gene Symbol:GAP43 ( B-50,PP46 )
Gene Full Name: growth associated protein 43
Band: 3q13.31
Quick LinksEntrez ID:2596; OMIM: 162060; Uniprot ID:NEUM_HUMAN; ENSEMBL ID: ENSG00000172020; HGNC ID: 4140
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200180N-cadherin signaling events
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1901Endometriosis
2069Schizophrenia
No data
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D020106 Acrylamide Acrylamide results in decreased expression of GAP43 mRNAdecreases expression 15749267
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GAP43 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of GAP43 mRNAdecreases expression 11377751
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of GAP43 mRNAincreases expression 11377751
D001151 Arsenic Arsenic results in decreased expression of GAP43 mRNAdecreases expression 19654921
D020001 1-Butanol 1-Butanol inhibits the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]decreases reaction|increases expression 18004999
D004390 Chlorpyrifos Chlorpyrifos affects the expression of GAP43 mRNAaffects expression 17452286
D003010 Clorgyline Clorgyline results in decreased expression of GAP43 proteindecreases expression 12480131
C010902 decabromobiphenyl ether decabromobiphenyl ether affects the expression of GAP43 proteinaffects expression 18061678
C010902 decabromobiphenyl ether decabromobiphenyl ether results in increased expression of GAP43 proteinincreases expression 18753049
D003976 Diazinon Diazinon results in increased expression of GAP43 mRNAincreases expression 17452286
D002117 Calcitriol Calcitriol results in increased expression of GAP43 mRNAincreases expression 16002434
D016291 Dizocilpine Maleate Dizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]decreases reaction|increases expression 8774942
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of GAP43 mRNAaffects cotreatment|decreases expression 17404688
D000431 Ethanol Ethanol results in decreased expression of GAP43 mRNAdecreases expression 15940294
D000431 Ethanol Thyroxine inhibits the reaction [Ethanol results in decreased expression of GAP43 mRNA]decreases expression|decreases reaction 15940294
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GAP43 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GAP43 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GAP43 mRNAdecreases expression 17351261
15834898
17557909
D015025 Zearalenone Zearalenone results in decreased expression of GAP43 mRNAdecreases expression 17557909
D005473 Fluoxetine Fluoxetine results in decreased expression of GAP43 mRNAdecreases expression 17950272
D005690 Galactose Quercetin inhibits the reaction [Galactose results in decreased expression of GAP43 mRNA]decreases expression|decreases reaction 16707173
D007099 Imipramine Imipramine results in decreased expression of GAP43 mRNAdecreases expression 17950272
D007608 Kainic Acid Dizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]decreases reaction|increases expression 8774942
D007608 Kainic Acid Kainic Acid results in increased expression of GAP43 mRNAincreases expression 8774942
D007608 Kainic Acid Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]decreases reaction|increases expression 8774942
C063302 KN 62 KN 62 inhibits the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]decreases reaction|increases expression 18004999
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of GAP43 mRNAdecreases expression 12057914
D008468 Meclizine Meclizine affects the expression of GAP43 proteinaffects expression 12388792
D008535 Megestrol Megestrol affects the expression of GAP43 proteinaffects expression 12388792
D008704 Methazolamide Methazolamide affects the expression of GAP43 proteinaffects expression 12388792
D009532 Nickel Nickel affects the expression of GAP43 mRNAaffects expression 18812211
D010424 Pentobarbital Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]decreases reaction|increases expression 8774942
D010622 Phencyclidine Phencyclidine results in increased expression of GAP43 mRNAincreases expression 11377751
D011189 Potassium Chloride 1-Butanol inhibits the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]decreases reaction|increases expression 18004999
D011189 Potassium Chloride CAMK2D protein affects the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]affects reaction|increases expression 18004999
D011189 Potassium Chloride KN 62 inhibits the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]decreases reaction|increases expression 18004999
D011189 Potassium Chloride PLD2 protein affects the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]affects reaction|increases expression 18004999
D011189 Potassium Chloride Potassium Chloride results in increased expression of GAP43 mRNAincreases expression 18004999
D011189 Potassium Chloride Potassium Chloride results in increased expression of GAP43 proteinincreases expression 18004999
D011189 Potassium Chloride U 0126 inhibits the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]decreases reaction|increases expression 18004999
D011189 Potassium Chloride U 0126 inhibits the reaction [Potassium Chloride results in increased expression of GAP43 protein]decreases reaction|increases expression 18004999
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of GAP43 mRNAaffects cotreatment|decreases expression 17404688
D011794 Quercetin Quercetin inhibits the reaction [Galactose results in decreased expression of GAP43 mRNA]decreases expression|decreases reaction 16707173
C059514 resveratrol resveratrol results in decreased expression of GAP43 mRNAdecreases expression 12002526
C010327 salinomycin salinomycin results in decreased expression of GAP43 mRNAdecreases expression 19682730
C017947 sodium arsenite sodium arsenite results in increased expression of GAP43 mRNAincreases expression 12016162
D013467 Sulindac Sulindac affects the expression of GAP43 proteinaffects expression 12388792
D014284 Triiodothyronine Triiodothyronine results in increased expression of GAP43 mRNAincreases expression 15708448
D014284 Triiodothyronine Triiodothyronine results in increased expression of GAP43 proteinincreases expression 15708448
D013974 Thyroxine Thyroxine inhibits the reaction [Ethanol results in decreased expression of GAP43 mRNA]decreases expression|decreases reaction 15940294
D013974 Thyroxine Thyroxine results in increased expression of GAP43 mRNAincreases expression 15940294
D013974 Thyroxine Thyroxine results in decreased expression of GAP43 mRNAdecreases expression 17403546
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GAP43 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GAP43 mRNAincreases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of GAP43 proteinincreases expression 16849523
D014212 Tretinoin Tretinoin results in increased expression of GAP43 mRNAincreases expression 15708448
D014212 Tretinoin Tretinoin results in increased expression of GAP43 proteinincreases expression 15708448
17130476
C113580 U 0126 U 0126 inhibits the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]decreases reaction|increases expression 18004999
C113580 U 0126 U 0126 inhibits the reaction [Potassium Chloride results in increased expression of GAP43 protein]decreases reaction|increases expression 18004999
D014635 Valproic Acid Valproic Acid results in increased expression of GAP43 mRNAincreases expression 19101580
D014700 Verapamil Verapamil affects the expression of GAP43 proteinaffects expression 12388792
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.0614745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 11.7718926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.7711752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 11.778875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5419490988
MESH:D000138 Acidosis Ammonium Chloride 9.0418287403
MESH:D000138 Acidosis Ethanol 9.0411192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5017505938
MESH:D000168 Acrocephalosyndactylia U 0126 5.0517694057
MESH:D058186 Acute Kidney Injury resveratrol 7.7416538975
MESH:D058186 Acute Kidney Injury Sulindac 7.747897758
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.2711850527 18653653
MESH:D055371 Acute Lung Injury Nickel 8.2716166738
MESH:D000230 Adenocarcinoma Estradiol 6.4111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.4114692618
MESH:D000230 Adenocarcinoma Sulindac 6.4111910360
MESH:D000236 Adenoma resveratrol 6.3615688382
MESH:D000236 Adenoma Sulindac 6.3610223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.9516835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.2316460482 11535846 19003578 11874996 12394442 17611924 15623613
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2615276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.3317306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.3317306315 16712894
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 7.7516611668 11874814 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 7.7516487989
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8815451039 15451040
MESH:D000505 Alopecia Tretinoin 3.2715955085
MESH:D000544 Alzheimer Disease resveratrol 2.4716183991 16162502
MESH:D000550 Amblyopia Valproic Acid 4.7917688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5811748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.8517084956
MESH:D000853 Anophthalmos Ethanol 4.4015513904
MESH:D001008 Anxiety Disorders Ethanol 18.4311141031
MESH:D001008 Anxiety Disorders Fluoxetine 18.4318083778
MESH:D001008 Anxiety Disorders Pentobarbital 18.4311141031 18313124
MESH:D001008 Anxiety Disorders Valproic Acid 18.4317497229
MESH:D020261 Arsenic Poisoning Arsenic 2.7416251483 12569548 18414634 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.6915885639
MESH:D001169 Arthritis, Experimental resveratrol 10.6917115116
MESH:D001169 Arthritis, Experimental Tretinoin 10.6916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1616292516
MESH:D001249 Asthma Tretinoin 2.2116456186
MESH:D001259 Ataxia 1-Butanol 5.187820390
MESH:D001260 Ataxia Telangiectasia Quercetin 4.5515336622
MESH:D050197 Atherosclerosis Arsenic 6.0119371607 12928151
MESH:D050197 Atherosclerosis resveratrol 6.0117967414 16873680
MESH:D001321 Autistic Disorder Fluoxetine 2.5718775368 19232924
MESH:D001321 Autistic Disorder Valproic Acid 2.5719232924 17688650 15238991 18558336 18177632 18316065 17157402 17507914 18940202 18985861 19460635 18396377 16609825 20603192 18775368
MESH:D001327 Autoimmune Diseases Quercetin 3.9919761891
MESH:D001471 Barrett Esophagus Tretinoin 3.9916935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.8517594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.6612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.6616197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.0815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.088888407
MESH:D001913 Bowen's Disease Sulindac 4.9111207687
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9017868700
MESH:D001930 Brain Injuries Progesterone 3.8415665606 15845082 15380490
MESH:D002545 Brain Ischemia resveratrol 3.8517600658
MESH:D001943 Breast Neoplasms Acrylamide 7.6618183576 16253758
MESH:D001943 Breast Neoplasms Calcitriol 7.6611237771
MESH:D001943 Breast Neoplasms Estradiol 7.6612948864 16675129 18497071 17018787 17289903 17261762 14630087 19861407
MESH:D001943 Breast Neoplasms Nickel 7.6615986119
MESH:D001943 Breast Neoplasms Progesterone 7.6616175315 15562024 17614352
MESH:D001943 Breast Neoplasms Quercetin 7.6618628248
MESH:D001943 Breast Neoplasms resveratrol 7.6616393696 17651959 17534123
MESH:D001943 Breast Neoplasms salinomycin 7.6619682730
MESH:D001943 Breast Neoplasms Sulindac 7.6616642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.6620435547
MESH:D001943 Breast Neoplasms Tretinoin 7.6616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1616813970
MESH:D002056 Burns Ethanol 4.2316374292
MESH:D002105 Cadmium Poisoning Quercetin 5.1116962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3417687452 15504454
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7216168501
MESH:D006528 Carcinoma, Hepatocellular Arsenic 12.7917306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Estradiol 12.7916924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 12.7915763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular Quercetin 12.7912508355 19519916
MESH:D006528 Carcinoma, Hepatocellular resveratrol 12.7919321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 12.7917306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 12.791917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.1616675471
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.5317234771
MESH:D002294 Carcinoma, Squamous Cell Arsenic 12.8117687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 12.8111237771
MESH:D002294 Carcinoma, Squamous Cell resveratrol 12.8116227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 12.8118572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 12.8116051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.7018640142
MESH:D006332 Cardiomegaly Ethanol 18.8819332462
MESH:D006332 Cardiomegaly Methazolamide 18.8817124262
MESH:D006332 Cardiomegaly Quercetin 18.8819794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 18.8816120746 18850075 18670907
MESH:D006332 Cardiomegaly Thyroxine 18.8818093424
MESH:D002318 Cardiovascular Diseases Arsenic 6.5615738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases resveratrol 6.5615458977
MESH:D002340 Carotid Artery Diseases Arsenic 3.9518022660 16973168
MESH:D002386 Cataract Tretinoin 2.8317460283
MESH:D002418 Cattle Diseases Acrylamide 5.0112510666
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.7518566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 5.7519524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1616129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5420734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.5616105132 17333356 17110522 17681005 15861022 16919318 11677210
MESH:D002822 Choriocarcinoma Tretinoin 4.7216461808
MESH:D002971 Cleft Lip Ethanol 3.3515513904
MESH:D002972 Cleft Palate Ethanol 8.7115513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.7116354765 15340226 12621046 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 8.719407595
MESH:D003092 Colitis resveratrol 8.2316474422
MESH:D003092 Colitis Tretinoin 8.2317035595
MESH:D003110 Colonic Neoplasms Quercetin 5.4415741050 11134977 16640504 19440933 17148506 19056647 17191121
MESH:D003110 Colonic Neoplasms resveratrol 5.4416338953
MESH:D003110 Colonic Neoplasms Sulindac 5.4412458338 12902858
MESH:D015179 Colorectal Neoplasms Quercetin 3.3618852136 18095365
MESH:D015179 Colorectal Neoplasms resveratrol 3.3616550006
MESH:D015179 Colorectal Neoplasms Sulindac 3.3610666051 18059344 11197048 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7017141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.4716507316
MESH:D019465 Craniofacial Abnormalities Ethanol 4.9415451039 11198716 19302082 15513904 11873399 10194807 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.9415322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.949125849 17551590 9211117 10589399 14991402 16925845 8800419 9142499 9664655 9224671
MESH:D019465 Craniofacial Abnormalities Valproic Acid 4.948888407 17688650 16575769
MESH:D003866 Depressive Disorder Fluoxetine 7.7615014590
MESH:D003866 Depressive Disorder Imipramine 7.7620305041
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.5519470301 17100760 17244072
MESH:D003877 Dermatitis, Contact Nickel 4.242952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.3919496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.3916873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5617107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.8219279558
MESH:D003928 Diabetic Nephropathies resveratrol 7.8216286809
MESH:D003929 Diabetic Neuropathies Progesterone 4.0717187935
MESH:D003930 Diabetic Retinopathy Sulindac 4.7712861449 17621415
MESH:D056486 Drug-Induced Liver Injury Ethanol 5.4411566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.4420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.441733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4411462148
MESH:D004417 Dyspnea Diazinon 4.3616487989
MESH:D004421 Dystonia Valproic Acid 3.651851702
MESH:D004487 Edema Fluoxetine 13.4712798668
MESH:D004487 Edema Imipramine 13.4712798668
MESH:D004487 Edema resveratrol 13.478985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.4712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.4815322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.4818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 18.5915138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 18.5912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 18.5917692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 18.5917872969
MESH:D016889 Endometrial Neoplasms Estradiol 6.4611473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.4616569247
MESH:D004715 Endometriosis Progesterone 13.1916134523
MESH:D004715 Endometriosis Sulindac 13.1915652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 13.199294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 3.9717637181 15328337 15821434
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.4317923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.7317275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.483922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.7120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.237562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.887750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.633659116
MESH:D004938 Esophageal Neoplasms Ethanol 4.5916704527
MESH:D004938 Esophageal Neoplasms Sulindac 4.5912235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.7611564622
MESH:D005124 Eye Abnormalities Tretinoin 7.769664655 16938888
MESH:D005234 Fatty Liver Ethanol 10.9719236843 18620774 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 10.9715345470
MESH:D005234 Fatty Liver Valproic Acid 10.9719224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.2217920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8716946407 15513904 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0411858732
MESH:D005315 Fetal Diseases Valproic Acid 4.4516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.7218558336 8888407
MESH:D005334 Fever Lipopolysaccharides 3.6411852909 9205823
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.0514745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 4.7019069698
MESH:D005355 Fibrosis Quercetin 12.3919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.3920067830
MESH:D005355 Fibrosis Tretinoin 12.3917994277
MESH:D005534 Foot Diseases Arsenic 5.126392382
MESH:D005756 Gastritis Ethanol 4.2615046732
MESH:D005764 Gastroesophageal Reflux Sulindac 4.6011910360
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2516452187
MESH:D005909 Glioblastoma Quercetin 6.3119804834
MESH:D005909 Glioblastoma Tretinoin 6.3117312396
MESH:D005910 Glioma Quercetin 2.8717643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1510696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.8916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7216084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 5.749664655 14991402
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0116366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9511000095
MESH:D006505 Hepatitis Diazinon 4.1716487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.4812621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.5915709030
MESH:D006561 Herpes Simplex resveratrol 3.7516876885
MESH:D015658 HIV Infections Nickel 3.5817263646
MESH:D006689 Hodgkin Disease sodium arsenite 2.8012676792
MESH:D019584 Hot Flashes Estradiol 9.0817088409
MESH:D019584 Hot Flashes Fluoxetine 9.0814716179
MESH:D006849 Hydrocephalus Valproic Acid 4.4317688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6115340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Ethanol 6.8718783367
MESH:D006930 Hyperalgesia Tretinoin 6.8716870215
MESH:D006937 Hypercholesterolemia resveratrol 3.6217188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1516778211
MESH:D006943 Hyperglycemia Quercetin 3.6618262572 11834736
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.0817050553
MESH:D006949 Hyperlipidemias resveratrol 3.6316873680
MESH:D006973 Hypertension Arsenic 11.009931084 16076760 11953799
MESH:D006973 Hypertension Quercetin 11.0018356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.0018850075 18670907
MESH:D006973 Hypertension Verapamil 11.0017700361
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9317488730
MESH:D006987 Hypesthesia Arsenic 5.1216093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3916945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.0815869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.0817600658
MESH:D007247 Infertility, Female Acrylamide 9.0711020651
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.0712013081
MESH:D007248 Infertility, Male Acrylamide 13.7412507653 15749267 15355880 11020651
MESH:D007248 Infertility, Male Diazinon 13.7412948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 13.7417937319
MESH:D007248 Infertility, Male sodium arsenite 13.7412646999 15346721
MESH:D007249 Inflammation Fluoxetine 24.5112798668
MESH:D007249 Inflammation Imipramine 24.5112798668
MESH:D007249 Inflammation Lipopolysaccharides 24.5117237260 17963957 12878042 17255318 9205823
MESH:D007249 Inflammation Nickel 24.5116166738
MESH:D007249 Inflammation Progesterone 24.5115869954
MESH:D007249 Inflammation resveratrol 24.5116366677
MESH:D007249 Inflammation Sulindac 24.513291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 24.5112878042 12200463
MESH:D007251 Influenza, Human Quercetin 9.7316624496
MESH:D007251 Influenza, Human resveratrol 9.7316624496
MESH:D007333 Insulin Resistance Estradiol 2.6816627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.3517994277
MESH:D007414 Intestinal Neoplasms Sulindac 4.2610223192 12584176 12628509 12351151 12663524 10213222
MESH:D007417 Intestinal Polyps Sulindac 4.5911245490 12394442
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2317255318
MESH:D007569 Jaw Abnormalities Ethanol 14.9515513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 14.9516580747
MESH:D007569 Jaw Abnormalities Tretinoin 14.9515992940 17551590
MESH:D007627 Keloid Quercetin 4.5317086741
MESH:D007642 Keratosis Arsenic 4.5616930632 12749816
MESH:D007674 Kidney Diseases Estradiol 8.6715618244
MESH:D007674 Kidney Diseases Quercetin 8.6716962696
MESH:D007674 Kidney Diseases sodium arsenite 8.6720008137
MESH:D007680 Kidney Neoplasms Estradiol 2.6415610895
MESH:D007859 Learning Disorders Ethanol 3.7915451040
MESH:D007938 Leukemia Quercetin 5.7117468513
MESH:D007938 Leukemia Tretinoin 5.7117143497
MESH:D007948 Leukemia, Monocytic, Acute U 0126 4.8816972261
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3216482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.5816294345 19850784 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.5816294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 11.1617339181
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 11.1616087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 11.169834237 16140955 19035177 15748426 16891316 17506722 19075265 16766008 17361223 17217047 16823087 16331271 17294898 19225113 17107899 17301526 16788101 19029980 17712046 16935935 19642359 17368321 17649720 12679006 17339181
MESH:D007970 Leukopenia Lipopolysaccharides 4.2715821434
MESH:D017880 Limb Deformities, Congenital Ethanol 7.2817676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.289224671
MESH:D008064 Lipidoses Fluoxetine 7.9115342952 17567588
MESH:D008064 Lipidoses Imipramine 7.9115342952 17567588
MESH:D008103 Liver Cirrhosis Ethanol 3.1315289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6618295389
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 3.9512468960
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.8914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 7.8918166357
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 7.8912878042
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 7.8912741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.8912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 7.8918397230 16248980
MESH:D008107 Liver Diseases Arsenic 6.1011134558
MESH:D008107 Liver Diseases Chlorpyrifos 6.1015991261
MESH:D008107 Liver Diseases Sulindac 6.1014986274 16867024
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.2317347304 17207112
MESH:D008113 Liver Neoplasms Arsenic 12.3416368122
MESH:D008113 Liver Neoplasms Quercetin 12.3418980244
MESH:D008113 Liver Neoplasms resveratrol 12.3419321006 19812893 20405173 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 12.3416712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.3416984957
MESH:D008114 Liver Neoplasms, Experimental Quercetin 5.0219519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.0212151625
MESH:D008171 Lung Diseases sodium arsenite 2.8819095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8217228818
MESH:D055370 Lung Injury Lipopolysaccharides 3.5921114838
MESH:D008175 Lung Neoplasms Arsenic 5.9417306315 19168569 17976673
MESH:D008175 Lung Neoplasms Quercetin 5.9416280456
MESH:D008175 Lung Neoplasms sodium arsenite 5.9417306315 17077188 16712894 15276417 19931552
MESH:D008175 Lung Neoplasms Sulindac 5.9415713900 19359593
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.9419555203 11884234
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9017088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.5214749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.8215688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.0211408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.0217203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 12.0211606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 12.0219682730
MESH:D020149 Manganese Poisoning Estradiol 4.0419453300
MESH:D008527 Medulloblastoma Tretinoin 2.6017453147
MESH:D008545 Melanoma resveratrol 6.5917992120
MESH:D008545 Melanoma sodium arsenite 6.5916487513 19082730
MESH:D008545 Melanoma Sulindac 6.5916642371
MESH:D008545 Melanoma Tretinoin 6.5916752155
MESH:D008569 Memory Disorders Ethanol 3.7815451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.0016940565
MESH:D001523 Mental Disorders Fluoxetine 7.5016856516
MESH:D001523 Mental Disorders Imipramine 7.5016856516
MESH:D008659 Metabolic Diseases resveratrol 3.9917112576
MESH:D008881 Migraine Disorders Valproic Acid 2.8818803445 18765137
MESH:D009041 Motion Sickness Dextroamphetamine 5.081613127
MESH:D009101 Multiple Myeloma resveratrol 3.1616490592 14749477 17164350 16267019 17935668 17049120
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.4417962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.648888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.5417596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.5417596541
MESH:D009203 Myocardial Infarction Quercetin 5.4119595682
MESH:D009203 Myocardial Infarction resveratrol 5.4117015251 16525036 16456233 17188708 17125593 16317513
MESH:D017202 Myocardial Ischemia Arsenic 13.3315371236
MESH:D017202 Myocardial Ischemia resveratrol 13.3317125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 13.3312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.4616810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.4619207477
MESH:D009205 Myocarditis resveratrol 4.3317322642
MESH:D009207 Myoclonus Fluoxetine 5.458041377
MESH:D009369 Neoplasms Quercetin 7.0415185748
MESH:D009369 Neoplasms sodium arsenite 7.0411559025
MESH:D009369 Neoplasms Tretinoin 7.0416594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 7.838985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.8320056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3017289903
MESH:D009410 Nerve Degeneration Acrylamide 4.3711264303 12387367 12387366
MESH:D009422 Nervous System Diseases Acrylamide 4.6212164553 12507653
MESH:D009421 Nervous System Malformations Estradiol 13.9616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.9614600291
MESH:D009421 Nervous System Malformations Tretinoin 13.969125849
MESH:D009436 Neural Tube Defects Arsenic 15.0016620997
MESH:D009436 Neural Tube Defects sodium arsenite 15.0012854658
MESH:D009436 Neural Tube Defects Tretinoin 15.009142499
MESH:D009436 Neural Tube Defects Valproic Acid 15.0016359493 8888407
MESH:D019636 Neurodegenerative Diseases resveratrol 7.7017652729
MESH:D019636 Neurodegenerative Diseases Sulindac 7.7016850258 17266991
MESH:D020078 Neurogenic Inflammation Arsenic 15.5217056641
MESH:D020078 Neurogenic Inflammation Quercetin 15.5217929310
MESH:D020078 Neurogenic Inflammation resveratrol 15.5217929310
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.8715081274
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.0620418887
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 8.8819495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 8.8817513867
MESH:D010051 Ovarian Neoplasms Arsenic 20.5917306315
MESH:D010051 Ovarian Neoplasms Estradiol 20.5919401270
MESH:D010051 Ovarian Neoplasms Progesterone 20.5917393432 16525653
MESH:D010051 Ovarian Neoplasms Quercetin 20.5919005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 20.5915276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 20.5916936753
MESH:D010051 Ovarian Neoplasms U 0126 20.5916211241
MESH:D010146 Pain Fluoxetine 13.4512798668
MESH:D010146 Pain Imipramine 13.4512798668
MESH:D010146 Pain Sulindac 13.453291741
MESH:D010146 Pain Tretinoin 13.4516870215
MESH:D010190 Pancreatic Neoplasms Ethanol 11.0012384795
MESH:D010190 Pancreatic Neoplasms Quercetin 11.0016965848
MESH:D010190 Pancreatic Neoplasms Sulindac 11.0011504793 16820089
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.0015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8112520081
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 9.0011510240
MESH:D010523 Peripheral Nervous System Diseases Arsenic 9.0016093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.5616905509 6392382 15371236
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.588041377
MESH:D011014 Pneumonia Lipopolysaccharides 4.1212224865 11605937
MESH:D011041 Poisoning Diazinon 3.9617603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1518163543
MESH:D011230 Precancerous Conditions Quercetin 3.6219056647
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 13.7816679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.7811896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 13.7820603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.3515572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5020887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.0316140617
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0316289102 16644109 12479363 18247401 15754350
MESH:D011471 Prostatic Neoplasms Clorgyline 2.0319691856
MESH:D011471 Prostatic Neoplasms Estradiol 2.0316740699
MESH:D011471 Prostatic Neoplasms Quercetin 2.0317292933 14715546
MESH:D011471 Prostatic Neoplasms resveratrol 2.0316731767 17804756 17718901 17675339 15767336 17636462
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0316039940
MESH:D011507 Proteinuria Arsenic 7.9621343184
MESH:D011507 Proteinuria Tretinoin 7.9616636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.8916919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.1011422049 12752131
MESH:D011625 Pterygium Tretinoin 4.3616723453
MESH:D012021 Reflex, Abnormal Pentobarbital 5.5910930210
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1416325855
MESH:D015427 Reperfusion Injury resveratrol 3.0517520802 16317513 16314181 15827377 17058453
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4410835634
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.2211874814 17119214 16611668
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4318990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.4616611668 17119214
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.5416283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.5419155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6918045962
MESH:D012554 Schistosomiasis japonica Quercetin 5.1116862918
MESH:D012559 Schizophrenia Valproic Acid 2.0119110320 15737665
MESH:D012640 Seizures Dizocilpine Maleate 15.5217157343 11218047 12660363
MESH:D012640 Seizures Ethanol 15.529754883
MESH:D012640 Seizures Kainic Acid 15.521641125 10686065 16336964 19186208 14637104 19414003 18657176 17827730 15686955
MESH:D012640 Seizures Pentobarbital 15.529754883 10087439
MESH:D012640 Seizures Valproic Acid 15.5215475178 16876388 11738929 11044598 17978042 1511512 3137016 14763951
MESH:D020230 Serotonin Syndrome Fluoxetine 5.468704074
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.656418539
MESH:D012871 Skin Diseases Arsenic 2.6319834688 17453740 16702368 16353154 6392382 18709164 16759981 17938729 17548696 15952646 17050553
MESH:D012878 Skin Neoplasms Arsenic 15.6317976673 16251483 17029826 17050553 15504454 19538983
MESH:D012878 Skin Neoplasms resveratrol 15.638985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 15.6319524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.6316192470
MESH:D012878 Skin Neoplasms Tretinoin 15.6316467112
MESH:D012892 Sleep Deprivation Imipramine 5.7619798453
MESH:D012893 Sleep Disorders Kainic Acid 5.2719414003
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5016709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.8515862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 8.4412854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.4419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.1012833885
MESH:D013274 Stomach Neoplasms Ethanol 2.5018456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.5017261132
MESH:D013276 Stomach Ulcer Ethanol 3.1617918041 9562338 16755016 17189318 9211565 11906479
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1116321402
MESH:D013375 Substance Withdrawal Syndrome Ethanol 9.029754883
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 9.0211529278 9754883
MESH:D013733 Testicular Diseases Acrylamide 4.8015864552
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.7915821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.9112697716
MESH:D013959 Thyroid Diseases Thyroxine 10.9119910387
MESH:D013964 Thyroid Neoplasms Tretinoin 2.7016026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.2519048282
MESH:D014062 Tongue Neoplasms resveratrol 8.6716227395
MESH:D014062 Tongue Neoplasms Tretinoin 8.6716051514
MESH:D014178 Translocation, Genetic Valproic Acid 4.7917262798
MESH:D014376 Tuberculosis Tretinoin 2.9516040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.093119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 7.3817306315 15987713 11144890 18640142 19322015 19429237 17976673
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.3816720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.3816712894 16452187 11723127 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.228888407
MESH:D014570 Urologic Diseases Diazinon 4.8416487989
MESH:D002583 Uterine Cervical Neoplasms resveratrol 13.7317473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.7311813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 13.7316129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 13.7814692618
MESH:D014594 Uterine Neoplasms resveratrol 13.7817044934
MESH:D014594 Uterine Neoplasms Sulindac 13.7818645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.1716752155
MESH:D014652 Vascular Diseases Arsenic 10.4117056641
MESH:D014652 Vascular Diseases sodium arsenite 10.4117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.8817488730
MESH:D014820 Vitiligo Tretinoin 3.6516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8115886252
MESH:D009396 Wilms Tumor Tretinoin 3.6016287080
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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