Annotation Detail for TIPARP
Basic Information Top
| Gene Symbol: | TIPARP ( DKFZp434J214,DKFZp686N0351,DKFZp686P1838,FLJ40466,PARP7,pART14 ) |
|---|---|
| Gene Full Name: | TCDD-inducible poly(ADP-ribose) polymerase |
| Band: | 3q25.31 |
| Quick Links | Entrez ID:25976; OMIM: 612480; Uniprot ID:PARPT_HUMAN; ENSEMBL ID: ENSG00000163659; HGNC ID: 23696 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| No data |
| No data |
| Desease Name |
|---|
| Celiac Disease |
| IMMUNE |
| Desease Name |
|---|
| Ovarian cancer |
| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C548651 | 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester | 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TIPARP mRNA | increases expression | 19933214 |
| C014211 | 2,3,7,8-tetrachlorodibenzofuran | 2,3,7,8-tetrachlorodibenzofuran affects the expression of TIPARP mRNA | affects expression | 18343893 |
| C010914 | 2,4-diaminotoluene | 2,4-diaminotoluene results in increased expression of TIPARP mRNA | increases expression | 20713471 |
| C023035 | 3,4,5,3',4'-pentachlorobiphenyl | 3,4,5,3',4'-pentachlorobiphenyl affects the expression of TIPARP mRNA | affects expression | 18042819 |
| C035207 | 4-amino-2,6-dinitrotoluene | 4-amino-2,6-dinitrotoluene affects the expression of TIPARP mRNA | affects expression | 21346803 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of TIPARP mRNA | affects expression | 17562736 |
| C011512 | alpha-naphthoflavone | alpha-naphthoflavone results in decreased expression of TIPARP mRNA | decreases expression | 18762178 |
| C006632 | arsenic trioxide | arsenic trioxide results in increased expression of TIPARP mRNA | increases expression | 20458559 |
| D017638 | Asbestos, Crocidolite | Asbestos, Crocidolite results in increased expression of TIPARP mRNA | increases expression | 18687144 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of TIPARP mRNA | increases expression | 20106945 20064835 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of TIPARP mRNA | increases expression | 20713471 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TIPARP mRNA | decreases expression | 19150397 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TIPARP mRNA | increases expression | 20382639 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] | increases expression|increases reaction | 12147270 |
| D020122 | tert-Butylhydroperoxide | tert-Butylhydroperoxide results in increased expression of TIPARP mRNA | increases expression | 15336504 |
| D003513 | Cycloheximide | AHR protein promotes the reaction [Cycloheximide results in increased expression of TIPARP mRNA] | increases expression|increases reaction | 12147270 |
| D003513 | Cycloheximide | Cycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] | increases expression|increases reaction | 12147270 |
| D003513 | Cycloheximide | Cycloheximide results in increased expression of TIPARP mRNA | increases expression | 12147270 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of TIPARP mRNA | decreases expression | 20106945 |
| D003609 | Dactinomycin | Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] | decreases reaction|increases expression | 12147270 |
| D004958 | Estradiol | Estradiol affects the expression of TIPARP mRNA | affects expression | 14699072 |
| D004958 | Estradiol | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TIPARP mRNA | affects cotreatment|increases expression | 19619570 |
| D004958 | Estradiol | Estradiol results in increased expression of TIPARP mRNA | increases expression | 19619570 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol affects the expression of TIPARP mRNA | affects expression | 17555576 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of TIPARP mRNA | increases expression | 17942748 |
| C075954 | indolo(3,2-b)carbazole | indolo(3,2-b)carbazole results in increased expression of TIPARP mRNA | increases expression | 18762178 |
| C067713 | lactacystin | lactacystin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] | increases expression|increases reaction | 12147270 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in increased expression of TIPARP mRNA | increases expression | 20713471 |
| D015735 | Mifepristone | Mifepristone results in decreased expression of TIPARP mRNA | decreases expression | 17584828 |
| D010634 | Phenobarbital | Phenobarbital results in increased expression of TIPARP mRNA | increases expression | 19270015 |
| C006253 | pirinixic acid | pirinixic acid results in increased expression of TIPARP mRNA | increases expression | 18301758 18445702 |
| D011691 | Puromycin | Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] | increases expression|increases reaction | 12147270 |
| D020849 | Raloxifene | [Raloxifene co-treated with ESR1 protein] results in increased expression of TIPARP mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | [Tamoxifen co-treated with ESR1 protein] results in increased expression of TIPARP mRNA | affects cotreatment|increases expression | 19059307 |
| D013629 | Tamoxifen | Tamoxifen affects the expression of TIPARP mRNA | affects expression | 17555576 |
| D013749 | Tetrachlorodibenzodioxin | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TIPARP mRNA | affects cotreatment|increases expression | 19619570 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA | increases expression | 17968679 18762178 20106945 19619570 |
| D013749 | Tetrachlorodibenzodioxin | AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] | increases expression|increases reaction | 12147270 |
| D013749 | Tetrachlorodibenzodioxin | ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] | increases expression|increases reaction | 12147270 |
| D013749 | Tetrachlorodibenzodioxin | benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] | increases expression|increases reaction | 12147270 |
| D013749 | Tetrachlorodibenzodioxin | Cycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] | increases expression|increases reaction | 12147270 |
| D013749 | Tetrachlorodibenzodioxin | Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] | decreases reaction|increases expression | 12147270 |
| D013749 | Tetrachlorodibenzodioxin | lactacystin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] | increases expression|increases reaction | 12147270 |
| D013749 | Tetrachlorodibenzodioxin | Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] | increases expression|increases reaction | 12147270 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of TIPARP mRNA | affects expression | 18343893 |
| D013749 | Tetrachlorodibenzodioxin | [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TIPARP mRNA | affects binding|increases expression | 16214954 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA | increases expression | 15652763 16962184 12147270 17942748 18691609 16611356 18796159 19933214 20159946 15328365 11716501 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA | increases expression | 18796159 |
| D014415 | Tunicamycin | Tunicamycin results in increased expression of TIPARP mRNA | increases expression | 17127020 |
| C025643 | vinclozolin | vinclozolin affects the expression of TIPARP mRNA | affects expression | 19015723 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000008 | Abdominal Neoplasms | Tamoxifen | 4.26 | 14745880 | |
| MESH:D000014 | Abnormalities, Drug-Induced | 4-amino-2,6-dinitrotoluene | 12.64 | 7525203 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Phenobarbital | 12.64 | 6195326 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Tetrachlorodibenzodioxin | 12.64 | 15322242 11752688 14514962 | |
| MESH:D000152 | Acne Vulgaris | Ethinyl Estradiol | 3.66 | 17505938 | |
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 2.86 | 18653653 | |
| MESH:D000230 | Adenocarcinoma | arsenic trioxide | 9.53 | 11798837 19825857 | |
| MESH:D000230 | Adenocarcinoma | Benzo(a)pyrene | 9.53 | 20464547 20127859 | |
| MESH:D000230 | Adenocarcinoma | Estradiol | 9.53 | 11473722 | |
| MESH:D000230 | Adenocarcinoma | Ethinyl Estradiol | 9.53 | 14692618 | |
| MESH:D000236 | Adenoma | Benzo(a)pyrene | 6.33 | 6695378 | |
| MESH:D000236 | Adenoma | Methylcholanthrene | 6.33 | 10545420 6695378 | |
| MESH:D018248 | Adenoma, Liver Cell | 3,4,5,3',4'-pentachlorobiphenyl | 22.62 | 16628245 | |
| MESH:D018248 | Adenoma, Liver Cell | Phenobarbital | 22.62 | 17620307 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 22.62 | 16434500 | |
| MESH:D018248 | Adenoma, Liver Cell | Tetrachlorodibenzodioxin | 22.62 | 16835633 | |
| MESH:D000419 | Albuminuria | Raloxifene | 4.33 | 17451421 17308373 | |
| MESH:D000544 | Alzheimer Disease | Raloxifene | 2.48 | 15800139 | |
| MESH:D000740 | Anemia | Tetrachlorodibenzodioxin | 2.71 | 11748828 | |
| MESH:D000799 | Angioedema | Acetaminophen | 3.56 | 10982225 | |
| MESH:D001008 | Anxiety Disorders | vinclozolin | 3.42 | 19015723 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Benzo(a)pyrene | 3.80 | 19183758 | |
| MESH:D001161 | Arteriosclerosis | Ethinyl Estradiol | 3.19 | 11256880 | |
| MESH:D001169 | Arthritis, Experimental | Ethinyl Estradiol | 2.49 | 15885639 | |
| MESH:D050197 | Atherosclerosis | Methylcholanthrene | 3.29 | 11922910 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.45 | 18445737 | |
| MESH:D001778 | Blood Coagulation Disorders | arsenic trioxide | 13.83 | 16206674 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 13.83 | 19483382 | |
| MESH:D001778 | Blood Coagulation Disorders | Tetrachlorodibenzodioxin | 13.83 | 12125929 | |
| MESH:D001836 | Body Weight Changes | Tetrachlorodibenzodioxin | 3.51 | 15340226 | |
| MESH:D001848 | Bone Diseases, Developmental | Tetrachlorodibenzodioxin | 2.59 | 15746008 | |
| MESH:D019046 | Bone Marrow Neoplasms | Dactinomycin | 5.25 | 14601052 | |
| MESH:D001930 | Brain Injuries | Raloxifene | 4.20 | 16580743 | |
| MESH:D001943 | Breast Neoplasms | 2,4-diaminotoluene | 3.58 | 11921183 | |
| MESH:D001943 | Breast Neoplasms | Benzo(a)pyrene | 3.58 | 17474063 20146248 | |
| MESH:D001943 | Breast Neoplasms | Estradiol | 3.58 | 18497071 16675129 17018787 12948864 19861407 17289903 14630087 17261762 | |
| MESH:D001943 | Breast Neoplasms | Methylcholanthrene | 3.58 | 17474063 | |
| MESH:D001943 | Breast Neoplasms | Raloxifene | 3.58 | 17595753 15758505 17893378 15775269 17242785 17049068 16837676 17261762 15572757 17440819 16912660 17952589 | |
| MESH:D001943 | Breast Neoplasms | Tamoxifen | 3.58 | 19066611 15565566 18821012 16873071 18997820 19115204 17440819 19200415 19288272 15668708 19155303 19221464 20135344 19189212 18425577 19011961 20065188 17893378 17049068 20859285 20005174 18815881 20390343 21152245 19289846 19084267 19487384 20544844 19244106 19189210 18984771 18855134 19059307 16818667 19103187 17242785 16202921 19410462 11161223 18629630 19142967 21138602 18351453 17261762 16273361 | |
| MESH:D001943 | Breast Neoplasms | Tetrachlorodibenzodioxin | 3.58 | 20435547 | |
| MESH:D002051 | Burkitt Lymphoma | arsenic trioxide | 4.07 | 11589617 | |
| MESH:D002181 | Candidiasis, Vulvovaginal | Estradiol | 4.18 | 16111702 | |
| MESH:D002277 | Carcinoma | Methylcholanthrene | 7.61 | 10545420 | |
| MESH:D002277 | Carcinoma | Tetrachlorodibenzodioxin | 7.61 | 16835633 | |
| MESH:D018270 | Carcinoma, Ductal, Breast | Tamoxifen | 4.23 | 19066611 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 8.34 | 3084413 | |
| MESH:D006528 | Carcinoma, Hepatocellular | arsenic trioxide | 8.34 | 16217749 14691202 15073043 15553829 11135700 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Estradiol | 8.34 | 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Phenobarbital | 8.34 | 17173139 1701930 20007298 6705139 20935162 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Tamoxifen | 8.34 | 16924424 | |
| MESH:D002291 | Carcinoma, Papillary | arsenic trioxide | 4.59 | 19014326 | |
| MESH:D018288 | Carcinoma, Small Cell | arsenic trioxide | 3.88 | 12490120 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Benzo(a)pyrene | 1.97 | 20419170 | |
| MESH:D002295 | Carcinoma, Transitional Cell | Raloxifene | 8.70 | 17572228 | |
| MESH:D002295 | Carcinoma, Transitional Cell | Tamoxifen | 8.70 | 17572228 | |
| MESH:D006332 | Cardiomegaly | Tetrachlorodibenzodioxin | 2.21 | 18850075 16120746 18670907 | |
| MESH:D002318 | Cardiovascular Diseases | Raloxifene | 3.26 | 15775269 | |
| MESH:D002386 | Cataract | 4-amino-2,6-dinitrotoluene | 6.88 | 14694615 | |
| MESH:D002386 | Cataract | Acetaminophen | 6.88 | 10977129 | |
| MESH:D002471 | Cell Transformation, Neoplastic | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | 14.47 | 20889678 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Cyclosporine | 14.47 | 12371664 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Estradiol | 14.47 | 18566989 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Methylcholanthrene | 14.47 | 16192471 | |
| MESH:D002493 | Central Nervous System Diseases | Phenobarbital | 3.98 | 4080065 | |
| MESH:D018281 | Cholangiocarcinoma | 3,4,5,3',4'-pentachlorobiphenyl | 9.04 | 16628245 | |
| MESH:D018281 | Cholangiocarcinoma | Tetrachlorodibenzodioxin | 9.04 | 16835633 | |
| MESH:D002779 | Cholestasis | Cyclosporine | 12.16 | 19486331 | |
| MESH:D002779 | Cholestasis | Ethinyl Estradiol | 12.16 | 17110522 16105132 17333356 16919318 11677210 17681005 15861022 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 12.16 | 19176532 | |
| MESH:D002972 | Cleft Palate | Tetrachlorodibenzodioxin | 1.99 | 16354765 15668235 8697196 15340226 12621046 | |
| MESH:D003072 | Cognition Disorders | Raloxifene | 4.34 | 15800139 | |
| MESH:D015179 | Colorectal Neoplasms | arsenic trioxide | 1.86 | 20501625 | |
| MESH:D000013 | Congenital Abnormalities | 4-amino-2,6-dinitrotoluene | 8.41 | 15095906 | |
| MESH:D000013 | Congenital Abnormalities | Tetrachlorodibenzodioxin | 8.41 | 14669216 17141729 | |
| MESH:D023903 | Coronary Restenosis | arsenic trioxide | 3.92 | 12609071 | |
| MESH:D019465 | Craniofacial Abnormalities | 3,4,5,3',4'-pentachlorobiphenyl | 3.75 | 17686920 | |
| MESH:D019465 | Craniofacial Abnormalities | arsenic trioxide | 3.75 | 10525206 | |
| MESH:D019465 | Craniofacial Abnormalities | Tetrachlorodibenzodioxin | 3.75 | 10048152 20055451 15322242 | |
| MESH:D003456 | Cryptorchidism | vinclozolin | 4.07 | 14966744 | |
| MESH:D016757 | Death, Sudden, Cardiac | arsenic trioxide | 3.84 | 15213294 | |
| MESH:D003711 | Demyelinating Diseases | Tamoxifen | 4.09 | 19031437 | |
| MESH:D003865 | Depressive Disorder, Major | Raloxifene | 3.93 | 17474826 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 2.30 | 18249437 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Tetrachlorodibenzodioxin | 1.60 | 17107852 | |
| MESH:D003928 | Diabetic Nephropathies | Estradiol | 13.67 | 19279558 | |
| MESH:D003928 | Diabetic Nephropathies | Raloxifene | 13.67 | 15920148 17451421 17308373 | |
| MESH:D003928 | Diabetic Nephropathies | Tamoxifen | 13.67 | 19279558 | |
| MESH:D056486 | Drug-Induced Liver Injury | 4-amino-2,6-dinitrotoluene | 5.70 | 21346803 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 5.70 | 16109766 18071297 16081117 10663392 14986274 19739265 12594235 12153990 16177239 17906064 12540782 12705907 16227642 16781746 19164858 10915739 14550746 11421492 18713872 11287661 16485898 17522070 11529661 11461765 19085960 14725611 19420014 19416960 17562736 12392966 10774834 11743745 15968718 11739529 19923254 16393943 2444490 12958197 19370779 15619225 11834606 | |
| MESH:D056486 | Drug-Induced Liver Injury | Tetrachlorodibenzodioxin | 5.70 | 20420201 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 3.81 | 19426721 | |
| MESH:D004362 | Drug Toxicity | Tetrachlorodibenzodioxin | 2.56 | 11462148 | |
| MESH:D004421 | Dystonia | Phenobarbital | 3.75 | 1851702 | |
| MESH:D004487 | Edema | pirinixic acid | 10.00 | 12083418 | |
| MESH:D004487 | Edema | Raloxifene | 10.00 | 15860553 | |
| MESH:D004487 | Edema | Tetrachlorodibenzodioxin | 10.00 | 12711302 11000095 | |
| MESH:D004489 | Edema, Cardiac | 3,4,5,3',4'-pentachlorobiphenyl | 11.47 | 17686920 | |
| MESH:D004489 | Edema, Cardiac | Tetrachlorodibenzodioxin | 11.47 | 18230668 15322242 16714409 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Ethinyl Estradiol | 13.81 | 12538720 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Raloxifene | 13.81 | 15845917 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Tamoxifen | 13.81 | 19031437 | |
| MESH:D016889 | Endometrial Neoplasms | Estradiol | 6.79 | 18566989 11473722 19148513 | |
| MESH:D016889 | Endometrial Neoplasms | Tamoxifen | 6.79 | 16202921 17893378 19155303 20544844 | |
| MESH:D004715 | Endometriosis | Mifepristone | 8.35 | 16134523 | |
| MESH:D004715 | Endometriosis | Tetrachlorodibenzodioxin | 8.35 | 10568697 9294722 | |
| MESH:D004831 | Epilepsies, Myoclonic | Phenobarbital | 3.83 | 3659116 | |
| MESH:D004828 | Epilepsies, Partial | Phenobarbital | 3.59 | 3922381 11558140 | |
| MESH:D004827 | Epilepsy | Phenobarbital | 2.75 | 20417680 | |
| MESH:D004832 | Epilepsy, Absence | Phenobarbital | 3.31 | 6401628 | |
| MESH:D017029 | Epilepsy, Complex Partial | Phenobarbital | 3.98 | 7750514 | |
| MESH:D004830 | Epilepsy, Tonic-Clonic | Phenobarbital | 3.74 | 3659116 | |
| MESH:D004938 | Esophageal Neoplasms | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | 6.76 | 20426865 | |
| MESH:D004938 | Esophageal Neoplasms | arsenic trioxide | 6.76 | 12903497 | |
| MESH:D004938 | Esophageal Neoplasms | Benzo(a)pyrene | 6.76 | 16530937 | |
| MESH:D005124 | Eye Abnormalities | Tetrachlorodibenzodioxin | 2.81 | 11564622 | |
| MESH:D005234 | Fatty Liver | arsenic trioxide | 27.46 | 15073043 | |
| MESH:D005234 | Fatty Liver | Cyclosporine | 27.46 | 19224547 | |
| MESH:D005234 | Fatty Liver | Ethinyl Estradiol | 27.46 | 15345470 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 27.46 | 20131406 19236843 | |
| MESH:D005234 | Fatty Liver | Raloxifene | 27.46 | 17473493 | |
| MESH:D005234 | Fatty Liver | Tamoxifen | 27.46 | 14986274 19224547 | |
| MESH:D052776 | Female Urogenital Diseases | Tamoxifen | 3.07 | 16709447 | |
| MESH:D005313 | Fetal Death | Tetrachlorodibenzodioxin | 3.18 | 11858732 | |
| MESH:D018221 | Fibromatosis, Abdominal | Tamoxifen | 4.25 | 14745880 | |
| MESH:D018222 | Fibromatosis, Aggressive | Tamoxifen | 3.90 | 19069698 | |
| MESH:D005354 | Fibrosarcoma | Methylcholanthrene | 4.66 | 14633661 10962813 | |
| MESH:D005355 | Fibrosis | Cyclosporine | 7.57 | 12639820 12168785 | |
| MESH:D005355 | Fibrosis | Tetrachlorodibenzodioxin | 7.57 | 20067830 | |
| MESH:D005706 | Gallbladder Neoplasms | arsenic trioxide | 4.00 | 16904648 | |
| MESH:D005756 | Gastritis | Acetaminophen | 3.39 | 16983495 | |
| MESH:D030342 | Genetic Diseases, Inborn | vinclozolin | 4.65 | 16973722 | |
| MESH:D005832 | Genital Diseases, Male | vinclozolin | 5.02 | 16417039 | |
| MESH:D005885 | Gingival Hyperplasia | Cyclosporine | 3.94 | 8708960 | |
| MESH:D006058 | Gonadal Disorders | Tetrachlorodibenzodioxin | 4.31 | 10696789 | |
| MESH:D006330 | Heart Defects, Congenital | 2,3,7,8-tetrachlorodibenzofuran | 14.87 | 11294989 | |
| MESH:D006330 | Heart Defects, Congenital | 3,4,5,3',4'-pentachlorobiphenyl | 14.87 | 17686920 20471113 | |
| MESH:D006330 | Heart Defects, Congenital | Benzo(a)pyrene | 14.87 | 20471113 | |
| MESH:D006330 | Heart Defects, Congenital | Tetrachlorodibenzodioxin | 14.87 | 10048152 11294989 | |
| MESH:D006331 | Heart Diseases | Raloxifene | 3.35 | 11110106 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 2.37 | 20558911 | |
| MESH:D006457 | Hemoglobinuria, Paroxysmal | Cyclosporine | 4.14 | 15720958 | |
| MESH:D006470 | Hemorrhage | Tetrachlorodibenzodioxin | 3.09 | 11000095 | |
| MESH:D006529 | Hepatomegaly | Phenobarbital | 12.80 | 16109766 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 12.80 | 18467677 19176532 19772884 16221962 | |
| MESH:D006529 | Hepatomegaly | Tetrachlorodibenzodioxin | 12.80 | 16120746 15340226 12621046 | |
| MESH:D006558 | Herpes Genitalis | Estradiol | 4.75 | 15709030 | |
| MESH:D019584 | Hot Flashes | Estradiol | 3.47 | 17088409 | |
| MESH:D006869 | Hydronephrosis | Tetrachlorodibenzodioxin | 3.76 | 8697196 15340226 16354765 16959395 18606429 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 2.48 | 16870215 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 2.94 | 20558911 | |
| MESH:D006973 | Hypertension | Cyclosporine | 7.94 | 10903974 | |
| MESH:D006973 | Hypertension | Raloxifene | 7.94 | 17577099 15787275 | |
| MESH:D006973 | Hypertension | Tetrachlorodibenzodioxin | 7.94 | 18670907 18850075 | |
| MESH:D007021 | Hypospadias | Ethinyl Estradiol | 3.54 | 16945680 16569931 | |
| MESH:D007247 | Infertility, Female | Ethinyl Estradiol | 3.20 | 12013081 | |
| MESH:D007248 | Infertility, Male | Ethinyl Estradiol | 6.05 | 17937319 | |
| MESH:D007248 | Infertility, Male | vinclozolin | 6.05 | 16467254 | |
| MESH:D007249 | Inflammation | Tamoxifen | 4.41 | 19457130 | |
| MESH:D007249 | Inflammation | Tetrachlorodibenzodioxin | 4.41 | 12200463 12878042 | |
| MESH:D007333 | Insulin Resistance | Estradiol | 6.59 | 16627594 16393666 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 6.59 | 16306350 | |
| MESH:D007569 | Jaw Abnormalities | Tetrachlorodibenzodioxin | 3.09 | 16580747 | |
| MESH:D007638 | Keratoconjunctivitis Sicca | Cyclosporine | 4.16 | 15604871 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 9.04 | 15629191 12587719 | |
| MESH:D007674 | Kidney Diseases | Cyclosporine | 9.04 | 18776723 10903974 8314463 | |
| MESH:D007674 | Kidney Diseases | Estradiol | 9.04 | 15618244 | |
| MESH:D007680 | Kidney Neoplasms | Cyclosporine | 11.07 | 12371664 | |
| MESH:D007680 | Kidney Neoplasms | Estradiol | 11.07 | 15610895 | |
| MESH:D007680 | Kidney Neoplasms | Tamoxifen | 11.07 | 18625569 | |
| MESH:D007889 | Leiomyoma | Raloxifene | 4.24 | 16973256 | |
| MESH:D007938 | Leukemia | arsenic trioxide | 2.69 | 15070760 | |
| MESH:D015459 | Leukemia-Lymphoma, Adult T-Cell | arsenic trioxide | 3.55 | 17077332 12560223 | |
| MESH:D007948 | Leukemia, Monocytic, Acute | arsenic trioxide | 4.03 | 16972261 | |
| MESH:D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | arsenic trioxide | 3.22 | 14633726 | |
| MESH:D007951 | Leukemia, Myeloid | arsenic trioxide | 3.51 | 19077051 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | arsenic trioxide | 2.09 | 19850784 17050201 20471514 16467208 16968895 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | arsenic trioxide | 3.03 | 16823087 19035177 11468182 11161223 15622746 12679006 15213294 16330433 19075265 9834237 16112521 19642359 17649720 15336539 16891316 16331271 17869043 17107899 16966277 12018890 15748426 17217047 12712474 19225113 17712046 | |
| MESH:D015458 | Leukemia, T-Cell | arsenic trioxide | 4.09 | 16882451 | |
| MESH:D007984 | Leydig Cell Tumor | vinclozolin | 4.45 | 16417039 | |
| MESH:D008064 | Lipidoses | Tamoxifen | 2.96 | 15342952 17567588 | |
| MESH:D008103 | Liver Cirrhosis | Phenobarbital | 2.74 | 21047994 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Estradiol | 4.62 | 14659978 14716833 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 4.62 | 15474484 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tamoxifen | 4.62 | 18564211 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tetrachlorodibenzodioxin | 4.62 | 12878042 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 3.68 | 11587558 16610002 12587719 12969438 19014921 16611625 19784758 19460945 | |
| MESH:D008107 | Liver Diseases | Phenobarbital | 3.68 | 19363144 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 2.99 | 17185352 16871587 | |
| MESH:D008113 | Liver Neoplasms | arsenic trioxide | 16.56 | 14682389 | |
| MESH:D008113 | Liver Neoplasms | Benzo(a)pyrene | 16.56 | 21137059 20195826 | |
| MESH:D008113 | Liver Neoplasms | Phenobarbital | 16.56 | 19482888 21047994 19812893 8742319 19073162 15975961 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 16.56 | 20007298 16377806 15890375 | |
| MESH:D008113 | Liver Neoplasms | Tamoxifen | 16.56 | 16684651 | |
| MESH:D008113 | Liver Neoplasms | Tetrachlorodibenzodioxin | 16.56 | 16984957 | |
| MESH:D008114 | Liver Neoplasms, Experimental | arsenic trioxide | 12.72 | 20377131 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Methylcholanthrene | 12.72 | 598648 1399818 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Phenobarbital | 12.72 | 2563599 1399818 18308698 17172636 6150874 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Tetrachlorodibenzodioxin | 12.72 | 12151625 | |
| MESH:D008133 | Long QT Syndrome | arsenic trioxide | 3.14 | 15213294 | |
| MESH:D055370 | Lung Injury | Asbestos, Crocidolite | 3.75 | 17365036 | |
| MESH:D008175 | Lung Neoplasms | arsenic trioxide | 6.19 | 11798837 19825857 | |
| MESH:D008175 | Lung Neoplasms | Benzo(a)pyrene | 6.19 | 18520028 6695378 20464547 18816296 20135361 20869020 17053015 20064080 18569708 | |
| MESH:D008175 | Lung Neoplasms | Methylcholanthrene | 6.19 | 20970405 16337739 16271038 7750092 11893704 9230183 10545420 6695378 20512841 1399818 17909032 15390079 21163286 | |
| MESH:D008175 | Lung Neoplasms | Tamoxifen | 6.19 | 18625569 | |
| MESH:D008175 | Lung Neoplasms | Tetrachlorodibenzodioxin | 6.19 | 19555203 11884234 | |
| MESH:D015674 | Mammary Neoplasms, Animal | Tamoxifen | 3.48 | 19428831 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | 2,4-diaminotoluene | 9.03 | 11921183 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Estradiol | 9.03 | 17203775 16891317 11408345 11807958 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Tamoxifen | 9.03 | 11731420 19196722 14580682 19196723 16827153 | |
| MESH:D020149 | Manganese Poisoning | Estradiol | 11.70 | 19453300 | |
| MESH:D020149 | Manganese Poisoning | Tamoxifen | 11.70 | 19453300 | |
| MESH:D008545 | Melanoma | Tamoxifen | 1.84 | 19393235 12393984 | |
| MESH:D018328 | Melanoma, Amelanotic | Tamoxifen | 3.90 | 15990972 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 3.29 | 19513568 | |
| MESH:D008654 | Mesothelioma | Asbestos, Crocidolite | 3.07 | 16966607 18303189 16166281 | |
| MESH:D008664 | Metal Metabolism, Inborn Errors | Cyclosporine | 4.50 | 16801185 | |
| MESH:D018200 | Mixed Tumor, Mullerian | Raloxifene | 5.27 | 15863610 | |
| MESH:D009062 | Mouth Neoplasms | Benzo(a)pyrene | 2.98 | 16381670 | |
| MESH:D009101 | Multiple Myeloma | arsenic trioxide | 6.76 | 19417148 11468182 14977855 15949261 19549372 | |
| MESH:D009101 | Multiple Myeloma | Raloxifene | 6.76 | 16497877 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 3.23 | 16239165 | |
| MESH:D009182 | Mycosis Fungoides | arsenic trioxide | 4.39 | 18349030 | |
| MESH:D009190 | Myelodysplastic Syndromes | arsenic trioxide | 2.98 | 16105982 16882451 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 2.03 | 19151258 | |
| MESH:D017202 | Myocardial Ischemia | Tetrachlorodibenzodioxin | 2.80 | 12213967 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Estradiol | 7.55 | 16810080 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 7.55 | 16411023 | |
| MESH:D020191 | Myoclonic Epilepsies, Progressive | Phenobarbital | 4.20 | 17484760 | |
| MESH:D009232 | Myxoma | Raloxifene | 5.27 | 16343187 | |
| MESH:D009361 | Neoplasm Invasiveness | arsenic trioxide | 3.69 | 16624393 | |
| MESH:D009362 | Neoplasm Metastasis | Tamoxifen | 2.44 | 19393235 | |
| MESH:D009364 | Neoplasm Recurrence, Local | Tamoxifen | 2.42 | 19410462 | |
| MESH:D009369 | Neoplasms | Benzo(a)pyrene | 4.36 | 11141357 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 4.36 | 17405874 | |
| MESH:D009376 | Neoplasms, Hormone-Dependent | Tamoxifen | 3.72 | 19196722 19189210 19200415 | |
| MESH:D009389 | Neovascularization, Pathologic | Estradiol | 3.45 | 17289903 | |
| MESH:D009402 | Nephrosis, Lipoid | Cyclosporine | 4.16 | 17954296 | |
| MESH:D009404 | Nephrotic Syndrome | Cyclosporine | 3.05 | 19348381 18481113 | |
| MESH:D009421 | Nervous System Malformations | Estradiol | 8.58 | 11399458 16427766 | |
| MESH:D009421 | Nervous System Malformations | Tetrachlorodibenzodioxin | 8.58 | 14600291 | |
| MESH:D009436 | Neural Tube Defects | arsenic trioxide | 2.94 | 10525206 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 2.65 | 18514411 | |
| MESH:D009765 | Obesity | pirinixic acid | 1.75 | 20558911 | |
| MESH:D009784 | Occupational Diseases | 4-amino-2,6-dinitrotoluene | 3.86 | 14694615 | |
| MESH:D010018 | Osteomalacia | Phenobarbital | 4.08 | 17016548 | |
| MESH:D010024 | Osteoporosis | Raloxifene | 3.22 | 15775268 17882678 19059307 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | Raloxifene | 3.97 | 17823083 15579764 15758505 17893378 | |
| MESH:D010051 | Ovarian Neoplasms | marker/mechanism | 20852632 | ||
| MESH:D010051 | Ovarian Neoplasms | arsenic trioxide | 7.44 | 19769630 16624393 12452020 | |
| MESH:D010051 | Ovarian Neoplasms | Estradiol | 7.44 | 19401270 | |
| MESH:D010051 | Ovarian Neoplasms | Mifepristone | 7.44 | 16525653 | |
| MESH:D010146 | Pain | Acetaminophen | 2.17 | 16870215 | |
| MESH:D010190 | Pancreatic Neoplasms | arsenic trioxide | 4.96 | 15580305 | |
| MESH:D010190 | Pancreatic Neoplasms | Phenobarbital | 4.96 | 16965848 | |
| MESH:D016584 | Panic Disorder | Ethinyl Estradiol | 3.43 | 11578682 | |
| MESH:D010235 | Paraganglioma | arsenic trioxide | 3.90 | 19927285 | |
| MESH:D010382 | Peliosis Hepatis | Tetrachlorodibenzodioxin | 3.96 | 12520081 | |
| MESH:D010995 | Pleural Diseases | Asbestos, Crocidolite | 4.62 | 10923243 | |
| MESH:D017119 | Porphyria Cutanea Tarda | Tetrachlorodibenzodioxin | 3.29 | 18163543 | |
| MESH:D011230 | Precancerous Conditions | Cyclosporine | 8.19 | 12371664 | |
| MESH:D011230 | Precancerous Conditions | Phenobarbital | 8.19 | 2563599 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Tetrachlorodibenzodioxin | 8.56 | 11222880 11896295 11399792 11118676 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | vinclozolin | 8.56 | 18042343 18220299 19015723 | |
| MESH:D011469 | Prostatic Diseases | vinclozolin | 4.65 | 18220299 | |
| MESH:D019048 | Prostatic Intraepithelial Neoplasia | Estradiol | 3.63 | 20887781 | |
| MESH:D011471 | Prostatic Neoplasms | arsenic trioxide | 1.88 | 19131511 | |
| MESH:D011471 | Prostatic Neoplasms | Benzo(a)pyrene | 1.88 | 17292933 | |
| MESH:D011471 | Prostatic Neoplasms | Estradiol | 1.88 | 16740699 | |
| MESH:D011471 | Prostatic Neoplasms | Raloxifene | 1.88 | 16536755 16220300 15731164 | |
| MESH:D011471 | Prostatic Neoplasms | Tamoxifen | 1.88 | 15067354 | |
| MESH:D011472 | Prostatitis | vinclozolin | 4.65 | 18629315 | |
| MESH:D011537 | Pruritus | Ethinyl Estradiol | 3.03 | 16919318 15861022 | |
| MESH:D019310 | Pseudolymphoma | Phenobarbital | 4.21 | 12752131 | |
| MESH:D011565 | Psoriasis | Cyclosporine | 2.13 | 16882103 | |
| MESH:D011658 | Pulmonary Fibrosis | Asbestos, Crocidolite | 2.92 | 17322281 17365031 15814490 17975199 | |
| MESH:D011693 | Purpura | Raloxifene | 5.27 | 15770314 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 2.25 | 19058328 | |
| MESH:D015619 | Respiratory System Abnormalities | Tetrachlorodibenzodioxin | 3.57 | 18990726 | |
| MESH:D012512 | Sarcoma, Ewing's | arsenic trioxide | 9.70 | 16646077 | |
| MESH:D012512 | Sarcoma, Ewing's | Dactinomycin | 9.70 | 14601052 | |
| MESH:D012640 | Seizures | Phenobarbital | 2.51 | 3137016 4039156 11442880 16876388 | |
| MESH:D003294 | Seizures, Febrile | Phenobarbital | 4.54 | 6407741 | |
| MESH:D012878 | Skin Neoplasms | Benzo(a)pyrene | 8.62 | 10029692 19755658 | |
| MESH:D012878 | Skin Neoplasms | tert-Butylhydroperoxide | 8.62 | 8532709 | |
| MESH:D012878 | Skin Neoplasms | Tetrachlorodibenzodioxin | 8.62 | 16192470 | |
| MESH:D013088 | Spermatocele | Ethinyl Estradiol | 10.61 | 16709447 | |
| MESH:D013088 | Spermatocele | Tamoxifen | 10.61 | 16709447 | |
| MESH:D013119 | Spinal Cord Injuries | Tamoxifen | 3.76 | 19457130 | |
| MESH:D013274 | Stomach Neoplasms | arsenic trioxide | 2.30 | 17007042 | |
| MESH:D013274 | Stomach Neoplasms | Benzo(a)pyrene | 2.30 | 20155912 2093021 | |
| MESH:D020521 | Stroke | Raloxifene | 3.60 | 16837676 | |
| MESH:D019851 | Thrombophilia | Ethinyl Estradiol | 3.36 | 11994571 | |
| MESH:D013927 | Thrombosis | Ethinyl Estradiol | 2.92 | 15669648 | |
| MESH:D013959 | Thyroid Diseases | Tetrachlorodibenzodioxin | 3.62 | 12697716 | |
| MESH:D013964 | Thyroid Neoplasms | arsenic trioxide | 6.52 | 19014326 | |
| MESH:D013964 | Thyroid Neoplasms | Phenobarbital | 6.52 | 1399818 | |
| MESH:D013978 | Tibial Fractures | Estradiol | 12.76 | 19048282 | |
| MESH:D013978 | Tibial Fractures | Raloxifene | 12.76 | 19048282 | |
| MESH:D016171 | Torsades de Pointes | arsenic trioxide | 3.68 | 15213294 | |
| MESH:D001749 | Urinary Bladder Neoplasms | arsenic trioxide | 11.01 | 12845720 12973940 20435036 11780464 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Benzo(a)pyrene | 11.01 | 17053015 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Raloxifene | 11.01 | 17572228 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Tamoxifen | 11.01 | 8653321 16712894 17572228 | |
| MESH:D014581 | Urticaria | Acetaminophen | 2.72 | 10982225 | |
| MESH:D014594 | Uterine Neoplasms | Ethinyl Estradiol | 3.03 | 14692618 | |
| MESH:D014605 | Uveitis | Cyclosporine | 3.70 | 1336536 | |
| MESH:D054079 | Vascular Malformations | Tetrachlorodibenzodioxin | 4.31 | 12125929 | |
| MESH:D054556 | Venous Thromboembolism | Raloxifene | 4.92 | 16837676 | |
| MESH:D020246 | Venous Thrombosis | Ethinyl Estradiol | 3.29 | 14671159 15869587 | |
| MESH:D014846 | Vulvar Neoplasms | Raloxifene | 5.27 | 16343187 | |
| MESH:D019282 | Wasting Syndrome | Tetrachlorodibenzodioxin | 3.96 | 15886252 | |
| MESH:D014985 | Xerophthalmia | Cyclosporine | 4.16 | 17120751 |
| No data |