Annotation Detail for CHMP2B
Basic Information
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| Pathway ID | Pathway Name |
|---|
| hsa04144 | Endocytosis |
| Desease ID | Desease Name |
|---|
| H00078 | Pick's disease |
| Nervous system diseases |
| Neurodegenerative diseases |
| Desease ID | Desease Name |
|---|
| 1740 | Alzheimer's disease |
| 2035 | Brain disease |
| 2062 | Neurodegenerative disorder |
| 2134 | Amyotrophic lateral sclerosis |
| 2198 | Psychotic disorder |
| Desease Name |
|---|
| Dementia, familial, nonspecific |
| Amyotrophic lateral sclerosis, CHMP2B-related |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene results in increased expression of CHMP2B mRNA | increases expression | 20406850
|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of CHMP2B mRNA | affects expression | 17562736
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000690 |
Amyotrophic Lateral Sclerosis |
marker/mechanism |
|
| |
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.91 | 10982225 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.39 | 18445737 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
2.99 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
2.99 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.83 | 10977129 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
3.09 | 6135515 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
4.78 | 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
4.08 | 18551238 21346803 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
4.08 | 11421492 14550746 17522070 18071297 16781746 11287661 14725611 12540782 12958197 17906064 12705907 12153990 14986274 10915739 11461765 11529661 19416960 10663392 19739265 2444490 16227642 16177239 11834606 16109766 11739529 16081117 19420014 11743745 15968718 19085960 10774834 19370779 15619225 12392966 17562736 16393943 12594235 19164858 19923254 18713872 16485898 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
5.17 | 19426721 |
| OMIM:600795 |
FRONTOTEMPORAL DEMENTIA, CHROMOSOME 3-LINKED |
marker/mechanism |
|
| |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.74 | 16983495 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
3.11 | 16870215 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
2.44 | 15629191 12587719 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
3.41 | 16705839 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.71 | 19784758 16611625 19014921 11587558 19460945 12587719 12969438 16610002 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.74 | 16871587 17185352 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
2.29 | 7678174 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.82 | 2876784 2876786 6135515 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.33 | 19513568 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
4.75 | 18551238 7678174 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.31 | 18514411 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
3.94 | 16049721 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.82 | 16870215 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
2.85 | 18551238 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
2.43 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
5.20 | 10091137 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.58 | 10982225 |
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