AutismKB 2.0

Annotation Detail for DHRS7B


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Basic Information Top
Gene Symbol:DHRS7B ( DKFZp566O084,MGC8916,SDR32C1 )
Gene Full Name: dehydrogenase/reductase (SDR family) member 7B
Band: 17p11.2
Quick LinksEntrez ID:25979; OMIM: NA; Uniprot ID:DRS7B_HUMAN; ENSEMBL ID: ENSG00000109016; HGNC ID: 24547
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DHRS7B mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of DHRS7B mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of DHRS7B mRNAaffects expression 19483382
D002994 Clofibrate Clofibrate affects the expression of DHRS7B mRNAaffects expression 19483382
D005001 Ethionine Ethionine affects the expression of DHRS7B mRNAaffects expression 19483382
D009853 Omeprazole Omeprazole affects the expression of DHRS7B mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid results in increased expression of DHRS7B mRNAincreases expression 18301758
C006253 pirinixic acid pirinixic acid affects the expression of DHRS7B mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of DHRS7B mRNAaffects expression 19483382
D012643 Selenium Selenium results in increased expression of DHRS7B mRNAincreases expression 19244175
D013853 Thioacetamide Thioacetamide affects the expression of DHRS7B mRNAaffects expression 19483382
D014635 Valproic Acid Valproic Acid results in increased expression of DHRS7B mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.688875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9320041841 18218290 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 4.0119698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8616609825 20603192 18396377 19232924 18316065 19460635 18177632 17507914 17157402 15238991 18940202 18985861 18775368 18558336 17688650
MESH:D001714 Bipolar Disorder Valproic Acid 3.1417594078 20046352
MESH:D001778 Blood Coagulation Disorders Amiodarone 53.7219483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 53.7219483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 53.7219483382
MESH:D001778 Blood Coagulation Disorders Ethionine 53.7219483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 53.7219483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 53.7219483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 53.7219483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 53.7219483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.498888407
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.843084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 4.841701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 4.8417997003
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9319225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2818974383
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 3.611399818
MESH:D002637 Chest Pain Omeprazole 5.3215447763
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.4118291259
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 17688650 16575769
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.4516177239 11743745 16227642 11739529 11287661 17906064 19739265 18071297 16081117 18713872 16109766 12705907 14986274 10663392 11834606 11529661 11461765 15619225 16781746 16485898 14725611 12594235 10915739 14550746 19085960 19420014 15968718 17522070 19416960 11421492 16393943 12392966 12958197 19370779 19923254 19164858 2444490 12153990 12540782 10774834 17562736
MESH:D056486 Drug-Induced Liver Injury Amiodarone 12.4515265979 18218290
MESH:D056486 Drug-Induced Liver Injury Selenium 12.4515131321
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 12.4512963478
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.4519641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004381 Duodenal Ulcer Omeprazole 4.4915991576 16613094 17151854 21218061
MESH:D050171 Dyslipidemias Clofibrate 4.1616707586
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.333659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0018234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.716254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D005218 Fat Necrosis Thioacetamide 5.9416456712
MESH:D005234 Fatty Liver Amiodarone 20.0314986274
MESH:D005234 Fatty Liver Clofibrate 20.0319224547
MESH:D005234 Fatty Liver pirinixic acid 20.0320131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 20.0314986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2918558336 8888407
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006333 Heart Failure pirinixic acid 7.2220558911
MESH:D006333 Heart Failure Selenium 7.2217162251
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.7117276928 18665440 15929193
MESH:D006505 Hepatitis Thioacetamide 4.3816456712
MESH:D006529 Hepatomegaly Amiodarone 9.1715265979
MESH:D006529 Hepatomegaly pirinixic acid 9.1716221962 18467677 19772884 19176532
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.018137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D007037 Hypothyroidism Amiodarone 12.2118020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 12.2118031379 8137927
MESH:D007251 Influenza, Human Selenium 4.4116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.2119248655
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D008064 Lipidoses Amiodarone 3.6117567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5915474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 2.5915158331 12531686 16489207 12175628 18615449 18263696 12557150 10677585 16511523 17127702 18031379 14739098 16248980 15362042 15465738 16097051 18458672 12891558 15716488 12679928 18395095 15334695 17292413 11481614 15316131 16098781 15474484 18416461 15095483 15075984 18380797 15288473 17050028 12085344 18295389 18606216 17629604 11172339 15288472 18032466 11682029 16126171 17355460 15078482 16343077
MESH:D008107 Liver Diseases Acetaminophen 4.2319014921 16611625 19460945 11587558 12969438 12587719 19784758 16610002
MESH:D008107 Liver Diseases Thioacetamide 4.2318374380 15158337 16337175
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0817185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 10.0815633222 17276928 12479984 15313186
MESH:D008113 Liver Neoplasms pirinixic acid 1.8616377806 20007298 15890375
MESH:D008133 Long QT Syndrome Amiodarone 3.6917391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.4612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 12.0018516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 12.0017228818
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D008881 Migraine Disorders Valproic Acid 3.2918765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009181 Mycoses Amiodarone 5.1212754197 17974566
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.218888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 5.119802331
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0220603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.7612752131 11422049
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9012490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8311738929 1511512 15475178 14763951 17978042 11044598 16876388 3137016
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2818724381
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013272 Stomach Diseases Omeprazole 4.8018545984
MESH:D013276 Stomach Ulcer Amiodarone 8.0418087811
MESH:D013276 Stomach Ulcer Omeprazole 8.0410750652 16755016 17977527 18237397 11906479 15991576
MESH:D013610 Tachycardia Amiodarone 4.4511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3519225199
MESH:D013959 Thyroid Diseases Amiodarone 4.9819731979
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.7915710170
MESH:D013971 Thyrotoxicosis Amiodarone 5.0418020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.3817467628 11989578
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D014581 Urticaria Acetaminophen 3.1210982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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