AutismKB 2.0

Annotation Detail for TBC1D10B


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Basic Information Top
Gene Symbol:TBC1D10B ( DKFZp434P1750 )
Gene Full Name: TBC1 domain family, member 10B
Band: 16p11.2
Quick LinksEntrez ID:26000; OMIM: 613620; Uniprot ID:TB10B_HUMAN; ENSEMBL ID: ENSG00000169221; HGNC ID: 24510
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TBC1D10B mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TBC1D10B mRNAaffects expression 17562736
D001241 Aspirin Aspirin results in increased expression of TBC1D10B mRNAincreases expression 11906190
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TBC1D10B mRNAaffects binding|increases activity|increases expression 19710929
D012402 Rotenone Rotenone results in increased expression of TBC1D10B mRNAincreases expression 19013527
D013467 Sulindac Sulindac results in increased expression of TBC1D10B mRNAincreases expression 11906190
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 6.0214745880
MESH:D058186 Acute Kidney Injury Sulindac 4.647897758
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Sulindac 3.1711910360
MESH:D000236 Adenoma Sulindac 3.9410223192
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.9019003578 16460482 15623613 12394442 11535846 11874996 17611924
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.9720485159 12372130
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001913 Bowen's Disease Sulindac 5.8711207687
MESH:D001932 Brain Neoplasms Aspirin 4.7215481559
MESH:D001943 Breast Neoplasms Aspirin 2.8415161893
MESH:D001943 Breast Neoplasms Sulindac 2.8416642371
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.9416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.986135515
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003110 Colonic Neoplasms Aspirin 4.5212411196
MESH:D003110 Colonic Neoplasms Sulindac 4.5212458338 12902858
MESH:D015179 Colorectal Neoplasms Aspirin 3.1817047198
MESH:D015179 Colorectal Neoplasms Sulindac 3.1811076880 18059344 11197048 10666051
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003930 Diabetic Retinopathy Sulindac 5.5617621415 12861449
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9710774834 19739265 14725611 15619225 11529661 18071297 10663392 12958197 14550746 14986274 12153990 16109766 18713872 19923254 11461765 17522070 12540782 11834606 11743745 11287661 16781746 12594235 11739529 16393943 19416960 12392966 19420014 17562736 16227642 12705907 11421492 16177239 19370779 17906064 15968718 19085960 16485898 10915739 16081117 19164858 2444490
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004487 Edema Aspirin 8.1917259670
MESH:D004487 Edema pirinixic acid 8.1912083418
MESH:D004715 Endometriosis Sulindac 4.7815652904
MESH:D004938 Esophageal Neoplasms Sulindac 3.1912235107
MESH:D005234 Fatty Liver pirinixic acid 3.0920131406 19236843
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.9414745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.5919069698
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005764 Gastroesophageal Reflux Sulindac 5.3911910360
MESH:D005909 Glioblastoma Aspirin 4.1412870263
MESH:D006261 Headache Aspirin 5.4815240983
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 16221962 19772884 18467677
MESH:D012001 Hyperacusis Aspirin 6.2815240983
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007249 Inflammation Sulindac 3.443291741
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007414 Intestinal Neoplasms Sulindac 4.9412584176 10213222 10223192 12628509 12663524 12351151
MESH:D007417 Intestinal Polyps Sulindac 5.3412394442 11245490
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2416705839
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.4012468960
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.4619460945 12969438 11587558 16611625 12587719 19784758 19014921 16610002
MESH:D008107 Liver Diseases Sulindac 4.4614986274 16867024
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.747678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.7420007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.722876786 2876784 6135515
MESH:D008175 Lung Neoplasms Sulindac 2.6915713900 19359593
MESH:D008545 Melanoma Sulindac 2.8616642371
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008881 Migraine Disorders Aspirin 4.2815240983
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction Aspirin 6.3012692751
MESH:D009203 Myocardial Infarction pirinixic acid 6.3019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009325 Nausea Aspirin 5.7315240983
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.327678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009410 Nerve Degeneration Rotenone 4.1218619942 17356569 15790535
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.4318514411
MESH:D019636 Neurodegenerative Diseases Sulindac 9.4317266991 16850258
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7416049721
MESH:D010003 Osteoarthritis Aspirin 4.237009135
MESH:D010146 Pain Acetaminophen 13.0416870215
MESH:D010146 Pain Aspirin 13.046995502 6363464
MESH:D010146 Pain Sulindac 13.043291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.4411504793 16820089
MESH:D010300 Parkinson Disease Rotenone 3.0718191903 19232380 19114014 11445065 15451049 16412576 16140633 11535288 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 4.3815927086 15574749 15795934 18197244
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 6.0011156591
MESH:D020795 Photophobia Aspirin 6.2815240983
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012220 Rhinitis Aspirin 4.6812372130
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7418551238
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.6812269725
MESH:D020521 Stroke Aspirin 4.6316403987
MESH:D013927 Thrombosis Aspirin 4.8017672075
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 10.1010982225
MESH:D014581 Urticaria Aspirin 10.1010982225 20485159
MESH:D014594 Uterine Neoplasms Sulindac 4.9818645019
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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