AutismKB 2.0

Annotation Detail for DAK


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Basic Information Top
Gene Symbol:DAK ( DKFZp586B1621,MGC5621,NET45 )
Gene Full Name: dihydroxyacetone kinase 2 homolog (S. cerevisiae)
Band: 11q12.2
Quick LinksEntrez ID:26007; OMIM: NA; Uniprot ID:DHAK_HUMAN; ENSEMBL ID: ENSG00000149476; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00561Glycerolipid metabolism
hsa04622RIG-I-like receptor signaling pathway
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of DAK mRNAaffects expression 18343893
D000082 Acetaminophen Acetaminophen affects the expression of DAK mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of DAK mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of DAK mRNAaffects expression 19483382
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of DAK mRNAdecreases expression 15336504
D002994 Clofibrate Clofibrate affects the expression of DAK mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of DAK mRNAdecreases expression 20106945
D005001 Ethionine Ethionine affects the expression of DAK mRNAaffects expression 19483382
D009853 Omeprazole Omeprazole affects the expression of DAK mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid affects the expression of DAK mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of DAK mRNAaffects expression 19483382
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of DAK mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DAK mRNAdecreases expression 15328365
D013853 Thioacetamide Thioacetamide affects the expression of DAK mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8818218290 18057881 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 3.9619698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 60.6619483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 60.6619483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 60.6619483382
MESH:D001778 Blood Coagulation Disorders Ethionine 60.6619483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 60.6619483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 60.6619483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 60.6619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 60.6612125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 60.6619483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.793084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 4.791701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 4.7917997003
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9215710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2018974383
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 7.031399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0312371664
MESH:D002637 Chest Pain Omeprazole 5.2415447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.7918291259
MESH:D002779 Cholestasis Cyclosporine 7.9619486331
MESH:D002779 Cholestasis pirinixic acid 7.9619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 15668235 12621046 15340226 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1817906064 12705907 11461765 14550746 18071297 16393943 14986274 16485898 16081117 11743745 11287661 12153990 19739265 10774834 16177239 14725611 10915739 2444490 19085960 16781746 12958197 12540782 16227642 19370779 19416960 18713872 11834606 12392966 16109766 10663392 15619225 11739529 19164858 11529661 19420014 19923254 11421492 17562736 12594235 15968718 17522070
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.1818218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1820420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 9.1812963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.4216613094 17151854 21218061 15991576
MESH:D050171 Dyslipidemias Clofibrate 4.1216707586
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005218 Fat Necrosis Thioacetamide 5.8516456712
MESH:D005234 Fatty Liver Amiodarone 19.5014986274
MESH:D005234 Fatty Liver Clofibrate 19.5019224547
MESH:D005234 Fatty Liver Cyclosporine 19.5019224547
MESH:D005234 Fatty Liver pirinixic acid 19.5019236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Cyclosporine 8.8312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 7.1111294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.1110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.6515929193 18665440 17276928
MESH:D006505 Hepatitis Thioacetamide 4.3116456712
MESH:D006529 Hepatomegaly Amiodarone 15.0515265979
MESH:D006529 Hepatomegaly pirinixic acid 15.0519772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.0512621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.958137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418850075 18670907
MESH:D007037 Hypothyroidism Amiodarone 11.9618020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 11.968137927 18031379
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.948314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8012371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.1619248655
MESH:D008064 Lipidoses Amiodarone 3.5715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5212878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.5215288473 15316131 15095483 15716488 15474484 15288472 18295389 16511523 16098781 10677585 17127702 15078482 18263696 18032466 15334695 18031379 11682029 16126171 12679928 12557150 15362042 16489207 17050028 16343077 12175628 17292413 18395095 16097051 12891558 17355460 12531686 15158331 12085344 18380797 15075984 18458672 18416461 16248980 11481614 18606216 18615449 17629604 15465738 11172339 14739098
MESH:D008107 Liver Diseases Acetaminophen 4.1911587558 19784758 19460945 12969438 19014921 16611625 12587719 16610002
MESH:D008107 Liver Diseases Thioacetamide 4.1915158337 18374380 16337175
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8917185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 9.8915313186 15633222 12479984 17276928
MESH:D008113 Liver Neoplasms pirinixic acid 4.3416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1512151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6415350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.4312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.6118516814
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009181 Mycoses Amiodarone 5.0417974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 5.049802331
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111222880 11896295 11399792 11118676
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8812832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2018724381
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.718532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7116192470
MESH:D013272 Stomach Diseases Omeprazole 4.7318545984
MESH:D013276 Stomach Ulcer Amiodarone 7.8518087811
MESH:D013276 Stomach Ulcer Omeprazole 7.8516755016 11906479 10750652 18237397 17977527 15991576
MESH:D013610 Tachycardia Amiodarone 4.3811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2819225199
MESH:D013959 Thyroid Diseases Amiodarone 12.5119731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.5112697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.7415710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.9618020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.3111989578 17467628
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:00561 Glycerolipid metabolism
KEGG:01100 Metabolic pathways
KEGG:04622 RIG-I-like receptor signaling pathway
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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