AutismKB 2.0

Annotation Detail for L3MBTL1


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Basic Information Top
Gene Symbol:L3MBTL1 ( DKFZp586P1522,FLJ41181,H-L(3)MBT,KIAA0681,L3MBTL,dJ138B7.3 )
Gene Full Name: l(3)mbt-like 1 (Drosophila)
Band: 20q13.12
Quick LinksEntrez ID:26013; OMIM: 608802; Uniprot ID:LMBL1_HUMAN; ENSEMBL ID: ENSG00000185513; HGNC ID: 15905
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of L3MBTL1 mRNAincreases expression 19774075
D020849 Raloxifene Raloxifene results in decreased expression of L3MBTL1 mRNAdecreases expression 19429434
D013629 Tamoxifen Tamoxifen results in decreased expression of L3MBTL1 mRNAdecreases expression 19429434
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.4114745880
MESH:D000419 Albuminuria Raloxifene 5.1817451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.6115800139
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.2518218290 20041841 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 4.2319698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.3819483382
MESH:D001930 Brain Injuries Raloxifene 5.1316580743
MESH:D001943 Breast Neoplasms Raloxifene 2.2717893378 17242785 15758505 17952589 16912660 16837676 15572757 17595753 15775269 17049068 17440819 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 2.2715668708 11161223 19084267 19103187 20859285 20135344 19059307 19142967 21138602 17893378 17242785 15565566 19011961 18855134 18984771 19115204 19289846 18351453 17440819 19189210 21152245 18815881 20065188 19155303 18821012 18629630 17049068 19189212 20390343 20544844 19288272 16202921 16273361 19221464 17261762 18997820 16818667 19066611 19200415 20005174 19244106 16873071 19487384 19410462 18425577
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 5.1619066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8616924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 11.0317572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 11.0317572228
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 3.0119225199 15710769
MESH:D002318 Cardiovascular Diseases Raloxifene 3.7415775269
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.8318974383
MESH:D003072 Cognition Disorders Raloxifene 5.2715800139
MESH:D003711 Demyelinating Diseases Tamoxifen 5.0219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.5817474826
MESH:D003928 Diabetic Nephropathies Raloxifene 10.4517451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 10.4519279558
MESH:D056486 Drug-Induced Liver Injury Amiodarone 2.4818218290 15265979
MESH:D004487 Edema Raloxifene 3.8115860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 11.2615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 11.2619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.3117893378 19155303 20544844 16202921
MESH:D005234 Fatty Liver Amiodarone 16.2314986274
MESH:D005234 Fatty Liver Raloxifene 16.2317473493
MESH:D005234 Fatty Liver Tamoxifen 16.2314986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4716709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.2714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.9219069698
MESH:D006331 Heart Diseases Raloxifene 3.8311110106
MESH:D006529 Hepatomegaly Amiodarone 4.4015265979
MESH:D006937 Hypercholesterolemia Amiodarone 4.368137927 9751232
MESH:D006973 Hypertension Raloxifene 2.9917577099 15787275
MESH:D007037 Hypothyroidism Amiodarone 5.1717991464 18020914
MESH:D007249 Inflammation Tamoxifen 2.5519457130
MESH:D007680 Kidney Neoplasms Tamoxifen 3.4318625569
MESH:D007889 Leiomyoma Raloxifene 5.0316973256
MESH:D008064 Lipidoses Amiodarone 8.9615342952 17567588
MESH:D008064 Lipidoses Tamoxifen 8.9617567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3416684651
MESH:D008133 Long QT Syndrome Amiodarone 3.9211989578 17391786 15350150
MESH:D008171 Lung Diseases Amiodarone 3.6512587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.3418516814
MESH:D008175 Lung Neoplasms Tamoxifen 1.7518625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.5019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8811731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 5.4119453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.9215990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.4215863610
MESH:D009101 Multiple Myeloma Raloxifene 3.7416497877
MESH:D009181 Mycoses Amiodarone 5.7717974566 12754197
MESH:D009232 Myxoma Raloxifene 6.4216343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6219410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.8719189210 19200415 19196722
MESH:D010024 Osteoporosis Raloxifene 3.6415775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.7615758505 15579764 17893378 17823083
MESH:D011471 Prostatic Neoplasms Raloxifene 3.2815731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2815067354
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9812490602 12832656 11597910
MESH:D011693 Purpura Raloxifene 6.4215770314
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.8318724381
MESH:D013088 Spermatocele Tamoxifen 5.1616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.7819457130
MESH:D013276 Stomach Ulcer Amiodarone 3.7918087811
MESH:D020521 Stroke Raloxifene 4.1916837676
MESH:D013610 Tachycardia Amiodarone 4.8711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.7719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.6219731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.5118020914 19584973
MESH:D013978 Tibial Fractures Raloxifene 6.0819048282
MESH:D016171 Torsades de Pointes Amiodarone 4.9317467628 11989578
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.6917572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.6916712894 17572228 8653321
MESH:D054556 Venous Thromboembolism Raloxifene 6.0816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.4216343187
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03814 - 2-(N-Morpholino)-Ethanesulfonic Acid
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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