AutismKB 2.0

Annotation Detail for UPF2


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Basic Information Top
Gene Symbol:UPF2 ( DKFZp434D222,HUPF2,KIAA1408,MGC138834,MGC138835,RENT2,smg-3 )
Gene Full Name: UPF2 regulator of nonsense transcripts homolog (yeast)
Band: 10p14
Quick LinksEntrez ID:26019; OMIM: 605529; Uniprot ID:RENT2_HUMAN; ENSEMBL ID: ENSG00000151461; HGNC ID: 17854
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of UPF2 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of UPF2 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of UPF2 mRNAdecreases expression 19150397
C006253 pirinixic acid pirinixic acid results in decreased expression of UPF2 mRNAdecreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of UPF2 mRNA]decreases expression|increases reaction 17950772
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3611798837 19825857
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.4516206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.4519483382
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.033084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.0316217749 15073043 14691202 11135700 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9820889678
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6714725611 12705907 19370779 18071297 12392966 19416960 11834606 11529661 16109766 11743745 14986274 14550746 15968718 12540782 17522070 17906064 15619225 11461765 16393943 10915739 10663392 19739265 12153990 11287661 16485898 11739529 19923254 2444490 17562736 16227642 10774834 16177239 16781746 19420014 12958197 19085960 18713872 12594235 11421492 16081117 19164858
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7320426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7312903497
MESH:D005234 Fatty Liver arsenic trioxide 9.1615073043
MESH:D005234 Fatty Liver pirinixic acid 9.1620131406 19236843
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly pirinixic acid 3.5519772884 18467677 16221962 19176532
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007938 Leukemia arsenic trioxide 3.0015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1920471514 19850784 16467208 16968895 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4615213294 12712474 19225113 16330433 16823087 19035177 16966277 19075265 16891316 17869043 17649720 15622746 12679006 17217047 11161223 19642359 12018890 15336539 17107899 15748426 9834237 11468182 16331271 17712046 16112521
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.7019014921 16611625 19784758 12969438 19460945 12587719 16610002 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 4.8814682389
MESH:D008113 Liver Neoplasms pirinixic acid 4.8815890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3819417148 19549372 14977855 15949261 11468182
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3416882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3610525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5019769630 16624393 12452020
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6315580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2119131511
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5915213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6011780464 12845720 20435036 12973940
MESH:D014581 Urticaria Acetaminophen 3.4410982225
Pathway ID Pathway Name
KEGG:03015 mRNA surveillance pathway
KEGG:03013 RNA transport
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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