Gene Symbol:	TMEM98 ( DKFZp564K1964 )
Gene Full Name:	transmembrane protein 98
Band:	17q11.2
Quick Links	Entrez ID:26022; OMIM: NA; Uniprot ID:TMM98_HUMAN; ENSEMBL ID: ENSG00000006042; HGNC ID: 24529
Relate to Another Database:	SFARIGene; denovo-db

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
D000082	Acetaminophen	Acetaminophen affects the expression of TMEM98 mRNA	affects expression	17562736
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of TMEM98 mRNA	affects expression	17484886
D016572	Cyclosporine	Cyclosporine results in decreased expression of TMEM98 mRNA	decreases expression	20106945
D004041	Dietary Fats	Dietary Fats results in increased expression of TMEM98 mRNA	increases expression	18042831
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TMEM98 mRNA	increases expression	17942915
D004052	Diethylnitrosamine	MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of TMEM98 mRNA]	decreases reaction\|increases expression	17942915
C041786	palm oil	palm oil results in increased expression of TMEM98 mRNA	increases expression	18042831
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TMEM98 mRNA]	affects reaction\|decreases expression	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of TMEM98 mRNA	decreases expression	19482888
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TMEM98 mRNA	affects binding\|decreases expression\|increases activity	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of TMEM98 mRNA	increases expression	18301758 17426115

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000014	Abnormalities, Drug-Induced	Phenobarbital	3.78	6195326
MESH:D055371	Acute Lung Injury	pirinixic acid	3.38	18653653
MESH:D000236	Adenoma	Diethylnitrosamine	2.98	6695378 10737359
MESH:D018248	Adenoma, Liver Cell	Diethylnitrosamine	19.44	17162532 19052882 17620307 19061943 16434500 18056438
MESH:D018248	Adenoma, Liver Cell	Phenobarbital	19.44	17620307
MESH:D018248	Adenoma, Liver Cell	pirinixic acid	19.44	16434500
MESH:D000799	Angioedema	Acetaminophen	4.22	10982225
MESH:D001161	Arteriosclerosis	Dietary Fats	4.19	15238619
MESH:D001321	Autistic Disorder	Acetaminophen	1.40	18445737
MESH:D001778	Blood Coagulation Disorders	pirinixic acid	3.39	19483382
MESH:D001943	Breast Neoplasms	Dietary Fats	2.16	20435547
MESH:D001943	Breast Neoplasms	Diethylnitrosamine	2.16	17474063
MESH:D002252	Carbon Tetrachloride Poisoning	Carbon Tetrachloride	4.08	10355542 15700767 16192424 16124888 3786805 16097048 15673190 15721981 16050911 18705752 16227642 16011737
MESH:D006528	Carcinoma, Hepatocellular	Acetaminophen	6.82	3084413
MESH:D006528	Carcinoma, Hepatocellular	Carbon Tetrachloride	6.82	18788625
MESH:D006528	Carcinoma, Hepatocellular	Diethylnitrosamine	6.82	17055752 17428255 18691550 11831363 16502159 19519916 20727157 16807293 18665156 18506893 16878318 19052882 16935385 19335982 18056438 20101231 20214788 20512989 16328049 18785209 20432363 19539802 19208518 17162532 16681979 19394651 18971187 20084675 19919837 17173139 18788625 17138121 10737359 18978308 16569478 19171122 10672840 16698587 19418558 19701751 18210153 17978847 20514400 16288022 20007298 20524982 16830150 18494052 3581430 16540662 18393292 3084413 21159647 20935162 19383236 19107877 16779866 17761372 19822196
MESH:D006528	Carcinoma, Hepatocellular	Phenobarbital	6.82	1701930 6705139 17173139 20007298 20935162
MESH:D002386	Cataract	Acetaminophen	2.71	10977129
MESH:D002471	Cell Transformation, Neoplastic	Cyclosporine	7.14	12371664
MESH:D002471	Cell Transformation, Neoplastic	Diethylnitrosamine	7.14	21159647 7505956 2727394 17174075
MESH:D002493	Central Nervous System Diseases	Phenobarbital	4.56	4080065
MESH:D018281	Cholangiocarcinoma	Diethylnitrosamine	3.90	19052882
MESH:D002779	Cholestasis	Cyclosporine	8.35	19486331
MESH:D002779	Cholestasis	pirinixic acid	8.35	19176532
MESH:D003876	Dermatitis, Atopic	pirinixic acid	2.52	18249437
MESH:D003924	Diabetes Mellitus, Type 2	Diethylnitrosamine	2.23	20387270
MESH:D056486	Drug-Induced Liver Injury	Acetaminophen	6.55	12392966 10774834 19420014 12540782 17562736 16781746 19923254 18713872 16227642 12153990 2444490 11739529 19164858 11461765 16109766 14550746 10915739 11743745 16485898 11529661 11421492 19416960 11287661 10663392 19739265 14725611 17522070 12958197 19370779 17906064 16393943 15968718 19085960 16081117 16177239 11834606 18071297 12705907 14986274 12594235 15619225
MESH:D056486	Drug-Induced Liver Injury	Carbon Tetrachloride	6.55	19336974 7440962 6623471 19085960 3732212 7179309 7120509 2869522 3786805 6884620 11566570 16177239 15968718 10915739 15998439 16227642 9327722 21278145 4309450 10092053 17522070 15027814
MESH:D056486	Drug-Induced Liver Injury	Diethylnitrosamine	6.55	19107877
MESH:D056487	Drug-Induced Liver Injury, Chronic	Acetaminophen	4.47	19426721
MESH:D050171	Dyslipidemias	Dietary Fats	3.62	18367378
MESH:D004421	Dystonia	Phenobarbital	4.26	1851702
MESH:D004487	Edema	pirinixic acid	2.72	12083418
MESH:D004831	Epilepsies, Myoclonic	Phenobarbital	4.41	3659116
MESH:D004828	Epilepsies, Partial	Phenobarbital	4.25	3922381 11558140
MESH:D004827	Epilepsy	Phenobarbital	3.00	20417680
MESH:D004832	Epilepsy, Absence	Phenobarbital	3.76	6401628
MESH:D017029	Epilepsy, Complex Partial	Phenobarbital	4.56	7750514
MESH:D004830	Epilepsy, Tonic-Clonic	Phenobarbital	4.36	3659116
MESH:D004931	Esophageal Achalasia	Diethylnitrosamine	5.49	16302075
MESH:D005234	Fatty Liver	Carbon Tetrachloride	27.45	17595544 16045604 16239168 12795759 15959796 19224547 61145 12631006
MESH:D005234	Fatty Liver	Cyclosporine	27.45	19224547
MESH:D005234	Fatty Liver	Dietary Fats	27.45	18296743 17967931 19004024 19551842
MESH:D005234	Fatty Liver	Diethylnitrosamine	27.45	21071580 20387270
MESH:D005234	Fatty Liver	pirinixic acid	27.45	19236843 20131406
MESH:D005355	Fibrosis	Carbon Tetrachloride	16.66	18705752
MESH:D005355	Fibrosis	Cyclosporine	16.66	12639820 12168785
MESH:D005355	Fibrosis	Dietary Fats	16.66	18296743
MESH:D005756	Gastritis	Acetaminophen	4.05	16983495
MESH:D005885	Gingival Hyperplasia	Cyclosporine	4.56	8708960
MESH:D006333	Heart Failure	pirinixic acid	2.67	20558911
MESH:D006457	Hemoglobinuria, Paroxysmal	Cyclosporine	4.76	15720958
MESH:D006505	Hepatitis	Carbon Tetrachloride	3.88	19110552 19900420
MESH:D006529	Hepatomegaly	Phenobarbital	9.52	16109766
MESH:D006529	Hepatomegaly	pirinixic acid	9.52	18467677 19176532 16221962 19772884
MESH:D006930	Hyperalgesia	Acetaminophen	2.89	16870215
MESH:D006932	Hyperbilirubinemia	Carbon Tetrachloride	4.87	16899240
MESH:D006937	Hypercholesterolemia	Dietary Fats	3.83	21332399
MESH:D006943	Hyperglycemia	pirinixic acid	3.41	20558911
MESH:D006949	Hyperlipidemias	Dietary Fats	3.87	21332399
MESH:D006973	Hypertension	Cyclosporine	2.17	10903974
MESH:D006975	Hypertension, Portal	Carbon Tetrachloride	4.39	15338365
MESH:D007249	Inflammation	Dietary Fats	5.48	20412841
MESH:D007249	Inflammation	Diethylnitrosamine	5.48	18785209
MESH:D007333	Insulin Resistance	Dietary Fats	7.74	11836018 18457598
MESH:D007333	Insulin Resistance	pirinixic acid	7.74	16306350
MESH:D007638	Keratoconjunctivitis Sicca	Cyclosporine	4.82	15604871
MESH:D007674	Kidney Diseases	Acetaminophen	6.22	12587719 15629191
MESH:D007674	Kidney Diseases	Cyclosporine	6.22	8314463 18776723 10903974
MESH:D007680	Kidney Neoplasms	Cyclosporine	2.93	12371664
MESH:D008103	Liver Cirrhosis	Carbon Tetrachloride	16.76	21278145 17157831 16239168 11408273 17174718 11903743 17334410 16943688 16221502
MESH:D008103	Liver Cirrhosis	Dietary Fats	16.76	18296743
MESH:D008103	Liver Cirrhosis	Diethylnitrosamine	16.76	18665156 19638242 18407596 20032147 18522880
MESH:D008103	Liver Cirrhosis	Phenobarbital	16.76	21047994
MESH:D008106	Liver Cirrhosis, Experimental	Carbon Tetrachloride	2.38	13678700 17481882 17640975 18187930 15818738 18339082 15673190 18705752 12445421 15370692 12546737 18263696 18395914 15123356 17525996 18481824 18156304 15931870 12632514 18395095 18376398 16027843 17761835 18166357 15730626 18006644 15338365 17766677 17805973 14620537 17714472 18317297 18251166 18205269 12898905 12666154 17708605 18472094 12958196 17823541 18418968 15925388 18210741 17976157 16248980 18277467 17557913 12649538 18412020 14716496 12667390 14716833 15876570 16011737 17565644 17869086 15996030 16136751 16097048 17944888 16638106 17631135 10355542 14748882 12632512 16192424 14724832 17900296 17721639 12389079 18279442 17922224 12741479 18429990 15052691 15650968 12586293 18472332 15893842 16015684 14512876 11481614 18054572 16116963 15057751 18420326 20821823 15959796 12609069 16033810 17698563 15362042 12445418
MESH:D008106	Liver Cirrhosis, Experimental	pirinixic acid	2.38	15474484
MESH:D008107	Liver Diseases	Acetaminophen	9.82	19460945 12969438 12587719 19784758 11587558 16611625 19014921 16610002
MESH:D008107	Liver Diseases	Carbon Tetrachloride	9.82	15720792 16246199 15830285 17285989 16964402
MESH:D008107	Liver Diseases	Diethylnitrosamine	9.82	17034775
MESH:D008107	Liver Diseases	Phenobarbital	9.82	19363144
MESH:D017093	Liver Failure	Carbon Tetrachloride	4.47	15123358
MESH:D017114	Liver Failure, Acute	Acetaminophen	10.18	16871587 17185352
MESH:D017114	Liver Failure, Acute	Carbon Tetrachloride	10.18	16899240 14706259
MESH:D008113	Liver Neoplasms	Carbon Tetrachloride	11.36	19294768
MESH:D008113	Liver Neoplasms	Diethylnitrosamine	11.36	9163691 19294768 19833225 20101389 19690152 18648771 18754104 20118626 19426721 19090486 19638242 20501860 19850985 18978307 20137499 18977376 19642983 2422723 21047994 19254457 21071580 19551842 21167192 15175105 20434301 19073162 19812893 20452335 16942905 20583210 20492335 19427195 10737359 12112319 15885732 12771043 19996281 19255062 20405173 21278145 2862719 18644402 19256749 19499222
MESH:D008113	Liver Neoplasms	Phenobarbital	11.36	8742319 19073162 15975961 19812893 21047994 19482888
MESH:D008113	Liver Neoplasms	pirinixic acid	11.36	16377806 20007298 15890375
MESH:D008114	Liver Neoplasms, Experimental	Carbon Tetrachloride	10.71	12014681 15583823
MESH:D008114	Liver Neoplasms, Experimental	Diethylnitrosamine	10.71	19004024 21159647 16267830 18308698 17174075 16842330 19519916 3124819 2563599 17942915 19539802 19126423 19009564 18164116 17854601 18282651 18093689 18775883 18544905 18079962 9362446 18253720
MESH:D008114	Liver Neoplasms, Experimental	Phenobarbital	10.71	2563599 1399818 17172636 18308698 6150874
MESH:D008175	Lung Neoplasms	Diethylnitrosamine	1.76	6695378 20970405 20512841 21163286
MESH:D008546	Melanoma, Experimental	Acetaminophen	3.87	19513568
MESH:D008664	Metal Metabolism, Inborn Errors	Cyclosporine	5.16	16801185
MESH:D009135	Muscular Diseases	pirinixic acid	3.81	16239165
MESH:D009203	Myocardial Infarction	pirinixic acid	2.22	19151258
MESH:D015428	Myocardial Reperfusion Injury	pirinixic acid	3.13	16411023
MESH:D020191	Myoclonic Epilepsies, Progressive	Phenobarbital	4.81	17484760
MESH:D009362	Neoplasm Metastasis	Diethylnitrosamine	2.65	9029167 3581430
MESH:D009369	Neoplasms	pirinixic acid	2.05	17405874
MESH:D009402	Nephrosis, Lipoid	Cyclosporine	4.82	17954296
MESH:D009404	Nephrotic Syndrome	Cyclosporine	3.50	18481113 19348381
MESH:D019636	Neurodegenerative Diseases	Acetaminophen	8.86	18514411
MESH:D019636	Neurodegenerative Diseases	Diethylnitrosamine	8.86	20387270
MESH:D009461	Neurologic Manifestations	Diethylnitrosamine	5.49	20387270
MESH:D009765	Obesity	Dietary Fats	4.60	17217161 18674790 18457598 21332399 16723640 11836018 20132043 20518802 19632207
MESH:D009765	Obesity	pirinixic acid	4.60	20558911
MESH:D010018	Osteomalacia	Phenobarbital	4.70	17016548
MESH:D010146	Pain	Acetaminophen	2.59	16870215
MESH:D010190	Pancreatic Neoplasms	Diethylnitrosamine	5.51	16540662
MESH:D010190	Pancreatic Neoplasms	Phenobarbital	5.51	16965848
MESH:D011230	Precancerous Conditions	Cyclosporine	16.56	12371664
MESH:D011230	Precancerous Conditions	Diethylnitrosamine	16.56	2563599
MESH:D011230	Precancerous Conditions	Phenobarbital	16.56	2563599
MESH:D019310	Pseudolymphoma	Phenobarbital	4.87	12752131
MESH:D011565	Psoriasis	Cyclosporine	2.30	16882103
MESH:D015427	Reperfusion Injury	pirinixic acid	2.49	19058328
MESH:D012640	Seizures	Phenobarbital	2.84	4039156 3137016 11442880 16876388
MESH:D003294	Seizures, Febrile	Phenobarbital	5.16	6407741
MESH:D013274	Stomach Neoplasms	Diethylnitrosamine	1.76	18456281
MESH:D013964	Thyroid Neoplasms	Diethylnitrosamine	7.79	7505956
MESH:D013964	Thyroid Neoplasms	Phenobarbital	7.79	1399818
MESH:D014581	Urticaria	Acetaminophen	3.24	10982225
MESH:D014605	Uveitis	Cyclosporine	4.36	1336536
MESH:D015430	Weight Gain	Dietary Fats	3.95	16723640
MESH:D014985	Xerophthalmia	Cyclosporine	4.82	17120751

AutismKB 2.0

Annotation Detail for TMEM98

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics