AutismKB 2.0

Annotation Detail for TMEM98


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Basic Information Top
Gene Symbol:TMEM98 ( DKFZp564K1964 )
Gene Full Name: transmembrane protein 98
Band: 17q11.2
Quick LinksEntrez ID:26022; OMIM: NA; Uniprot ID:TMM98_HUMAN; ENSEMBL ID: ENSG00000006042; HGNC ID: 24529
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TMEM98 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TMEM98 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of TMEM98 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of TMEM98 mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TMEM98 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of TMEM98 mRNA]decreases reaction|increases expression 17942915
C041786 palm oil palm oil results in increased expression of TMEM98 mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TMEM98 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of TMEM98 mRNAdecreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TMEM98 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of TMEM98 mRNAincreases expression 18301758
17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.786195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000236 Adenoma Diethylnitrosamine 2.986695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 19.4417162532 19052882 17620307 19061943 16434500 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.4417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.4416434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.1620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1617474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0810355542 15700767 16192424 16124888 3786805 16097048 15673190 15721981 16050911 18705752 16227642 16011737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.823084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8218788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.8217055752 17428255 18691550 11831363 16502159 19519916 20727157 16807293 18665156 18506893 16878318 19052882 16935385 19335982 18056438 20101231 20214788 20512989 16328049 18785209 20432363 19539802 19208518 17162532 16681979 19394651 18971187 20084675 19919837 17173139 18788625 17138121 10737359 18978308 16569478 19171122 10672840 16698587 19418558 19701751 18210153 17978847 20514400 16288022 20007298 20524982 16830150 18494052 3581430 16540662 18393292 3084413 21159647 20935162 19383236 19107877 16779866 17761372 19822196
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.821701930 6705139 17173139 20007298 20935162
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.1421159647 7505956 2727394 17174075
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5512392966 10774834 19420014 12540782 17562736 16781746 19923254 18713872 16227642 12153990 2444490 11739529 19164858 11461765 16109766 14550746 10915739 11743745 16485898 11529661 11421492 19416960 11287661 10663392 19739265 14725611 17522070 12958197 19370779 17906064 16393943 15968718 19085960 16081117 16177239 11834606 18071297 12705907 14986274 12594235 15619225
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.5519336974 7440962 6623471 19085960 3732212 7179309 7120509 2869522 3786805 6884620 11566570 16177239 15968718 10915739 15998439 16227642 9327722 21278145 4309450 10092053 17522070 15027814
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.5519107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 27.4517595544 16045604 16239168 12795759 15959796 19224547 61145 12631006
MESH:D005234 Fatty Liver Cyclosporine 27.4519224547
MESH:D005234 Fatty Liver Dietary Fats 27.4518296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 27.4521071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 27.4519236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 16.6618705752
MESH:D005355 Fibrosis Cyclosporine 16.6612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 16.6618296743
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 9.5216109766
MESH:D006529 Hepatomegaly pirinixic acid 9.5218467677 19176532 16221962 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation Dietary Fats 5.4820412841
MESH:D007249 Inflammation Diethylnitrosamine 5.4818785209
MESH:D007333 Insulin Resistance Dietary Fats 7.7411836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.7416306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.228314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 16.7621278145 17157831 16239168 11408273 17174718 11903743 17334410 16943688 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 16.7618296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 16.7618665156 19638242 18407596 20032147 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 16.7621047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3813678700 17481882 17640975 18187930 15818738 18339082 15673190 18705752 12445421 15370692 12546737 18263696 18395914 15123356 17525996 18481824 18156304 15931870 12632514 18395095 18376398 16027843 17761835 18166357 15730626 18006644 15338365 17766677 17805973 14620537 17714472 18317297 18251166 18205269 12898905 12666154 17708605 18472094 12958196 17823541 18418968 15925388 18210741 17976157 16248980 18277467 17557913 12649538 18412020 14716496 12667390 14716833 15876570 16011737 17565644 17869086 15996030 16136751 16097048 17944888 16638106 17631135 10355542 14748882 12632512 16192424 14724832 17900296 17721639 12389079 18279442 17922224 12741479 18429990 15052691 15650968 12586293 18472332 15893842 16015684 14512876 11481614 18054572 16116963 15057751 18420326 20821823 15959796 12609069 16033810 17698563 15362042 12445418
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3815474484
MESH:D008107 Liver Diseases Acetaminophen 9.8219460945 12969438 12587719 19784758 11587558 16611625 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.8215720792 16246199 15830285 17285989 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 9.8217034775
MESH:D008107 Liver Diseases Phenobarbital 9.8219363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.1816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.1816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.3619294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.369163691 19294768 19833225 20101389 19690152 18648771 18754104 20118626 19426721 19090486 19638242 20501860 19850985 18978307 20137499 18977376 19642983 2422723 21047994 19254457 21071580 19551842 21167192 15175105 20434301 19073162 19812893 20452335 16942905 20583210 20492335 19427195 10737359 12112319 15885732 12771043 19996281 19255062 20405173 21278145 2862719 18644402 19256749 19499222
MESH:D008113 Liver Neoplasms Phenobarbital 11.368742319 19073162 15975961 19812893 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 11.3616377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.7112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.7119004024 21159647 16267830 18308698 17174075 16842330 19519916 3124819 2563599 17942915 19539802 19126423 19009564 18164116 17854601 18282651 18093689 18775883 18544905 18079962 9362446 18253720
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.712563599 1399818 17172636 18308698 6150874
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 20512841 21163286
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.659029167 3581430
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity Dietary Fats 4.6017217161 18674790 18457598 21332399 16723640 11836018 20132043 20518802 19632207
MESH:D009765 Obesity pirinixic acid 4.6020558911
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5116965848
MESH:D011230 Precancerous Conditions Cyclosporine 16.5612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 16.562563599
MESH:D011230 Precancerous Conditions Phenobarbital 16.562563599
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures Phenobarbital 2.844039156 3137016 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.797505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.791399818
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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