AutismKB 2.0

Annotation Detail for CYP4X1


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Basic Information Top
Gene Symbol:CYP4X1 ( MGC40051 )
Gene Full Name: cytochrome P450, family 4, subfamily X, polypeptide 1
Band: 1p33
Quick LinksEntrez ID:260293; OMIM: NA; Uniprot ID:CP4X1_HUMAN; ENSEMBL ID: ENSG00000186377; HGNC ID: 20244
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6402superpathway of melatonin degradation
PWY66-221nicotine degradation III
PWY66-201nicotine degradation II
PWY-6398melatonin degradation I
PWY66-241bupropion degradation
PWY-5451acetone degradation I (to methylglyoxal)
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CYP4X1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CYP4X1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CYP4X1 mRNAdecreases expression 20106945
20064835
D016572 Cyclosporine Cyclosporine results in decreased expression of CYP4X1 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of CYP4X1 mRNAdecreases expression 20106945
D005419 Flavonoids Flavonoids results in increased expression of CYP4X1 mRNAincreases expression 18035473
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of CYP4X1 mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid pirinixic acid results in increased expression of CYP4X1 mRNAincreases expression 15797250
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CYP4X1 mRNAdecreases expression 20106945
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of CYP4X1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1114514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.4111473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001321 Autistic Disorder Valproic Acid 1.9918985861 17507914 18775368 20603192 18177632 18316065 16609825 15238991 18940202 17688650 18558336 17157402 19232924 19460635 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.3715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.378888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7920146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 1.7917289903 17261762 16675129 19861407 14630087 12948864 17018787 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1012619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1016924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.9618566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1616354765 15340226 12621046 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5215322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5217688650 16575769 8888407
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.9219641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 16714409 15322242
MESH:D016889 Endometrial Neoplasms Estradiol 3.0919148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.747562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 14.0919224547
MESH:D005234 Fatty Liver pirinixic acid 14.0919236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 14.0919224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005355 Fibrosis Cyclosporine 9.2112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly pirinixic acid 8.9919176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.9916120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 16959395 16354765 18606429 8697196
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007249 Inflammation Flavonoids 5.2717296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2712878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.5516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.5516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.248314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.2415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7612371664
MESH:D007680 Kidney Neoplasms Estradiol 7.7615610895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.159163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1520195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 11.1515890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.158603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1512151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.456695378 20869020 18816296 20064080 20135361 17053015 18569708 20464547 18520028
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4519555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6617203775 11408345 11807958 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3118765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6916411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0811141357
MESH:D009369 Neoplasms pirinixic acid 5.0817405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 10.1411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1414600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2316359493 8888407
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2619401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2711896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.2720603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0717292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0716740699
MESH:D019310 Pseudolymphoma Valproic Acid 4.8112752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.851511512 16876388 14763951 11738929 11044598 17978042 3137016 15475178
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7210029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2317053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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