AutismKB 2.0

Annotation Detail for OSBPL3


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Basic Information Top
Gene Symbol:OSBPL3 ( DKFZp667P1518,KIAA0704,MGC21526,ORP-3,ORP3,OSBP3 )
Gene Full Name: oxysterol binding protein-like 3
Band: 7p15.3
Quick LinksEntrez ID:26031; OMIM: 606732; Uniprot ID:OSBL3_HUMAN; ENSEMBL ID: ENSG00000070882; HGNC ID: 16370
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of OSBPL3 mRNAaffects expression 17562736
D016589 Astemizole Astemizole results in increased expression of OSBPL3 mRNAincreases expression 20221588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of OSBPL3 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of OSBPL3 mRNAdecreases expression 19150397
D010634 Phenobarbital Phenobarbital results in increased expression of OSBPL3 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of OSBPL3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of OSBPL3 mRNAincreases expression 18301758
17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of OSBPL3 mRNA]increases expression|increases reaction 17950772
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of OSBPL3 mRNAaffects cotreatment|increases expression 19059307
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of OSBPL3 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of OSBPL3 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of OSBPL3 mRNAaffects cotreatment|decreases expression 19059307
D043343 Testosterone Propionate Testosterone Propionate results in decreased expression of OSBPL3 mRNAdecreases expression 15601916
D013752 Tetracycline Tetracycline results in decreased expression of OSBPL3 mRNAdecreases expression 16917069
D014635 Valproic Acid Valproic Acid results in increased expression of OSBPL3 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.186195326
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.188875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.7817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7816434500
MESH:D000419 Albuminuria Raloxifene 4.7617451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D000799 Angioedema Acetaminophen 12.7710982225
MESH:D000799 Angioedema Astemizole 12.772883202
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8615238991 17157402 18985861 18316065 18775368 18396377 20603192 17688650 16609825 19232924 18558336 17507914 18177632 18940202 19460635
MESH:D001714 Bipolar Disorder Valproic Acid 3.1417594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.498888407
MESH:D001930 Brain Injuries Raloxifene 4.6516580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9220146248 17474063
MESH:D001943 Breast Neoplasms Raloxifene 1.9216837676 15572757 17242785 15775269 16912660 17893378 17595753 17261762 17952589 17049068 17440819 15758505
MESH:D001943 Breast Neoplasms Tamoxifen 1.9219059307 19189210 17242785 19221464 19103187 19155303 20065188 18351453 18984771 15565566 16818667 11161223 21138602 17893378 18855134 15668708 19066611 19011961 19289846 19200415 17049068 19189212 16202921 19084267 18997820 20135344 19244106 18815881 21152245 19288272 19142967 20859285 19410462 19115204 18425577 18629630 16873071 20544844 17261762 20005174 17440819 16273361 20390343 18821012 19487384
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.653084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.651701930 20935162 20007298 6705139 17173139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6516924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.9417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.9417572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5415775269
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8220889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D003072 Cognition Disorders Raloxifene 4.7915800139
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 17688650 16575769
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2917474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003928 Diabetic Nephropathies Raloxifene 9.4517308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.4519279558
MESH:D004244 Dizziness Astemizole 6.683105558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5512594235 11834606 17522070 16227642 16393943 19416960 11739529 11461765 15968718 18071297 11529661 14550746 19164858 16109766 19923254 16081117 10663392 14986274 12392966 16177239 11421492 12958197 19370779 12705907 11743745 11287661 10774834 19085960 16485898 19739265 19420014 12540782 17562736 14725611 18713872 10915739 2444490 16781746 15619225 12153990 17906064
MESH:D056486 Drug-Induced Liver Injury Tetracycline 6.5517522070
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.551733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004421 Dystonia Phenobarbital 10.941851702
MESH:D004421 Dystonia Valproic Acid 10.941851702
MESH:D004487 Edema pirinixic acid 7.3612083418
MESH:D004487 Edema Raloxifene 7.3615860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.7915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1319155303 16202921 17893378 20544844
MESH:D004802 Eosinophilia Astemizole 4.971355641
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 11.393659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 11.393659116 17275665
MESH:D004828 Epilepsies, Partial Phenobarbital 10.7111558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 10.713922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.8920417680
MESH:D004827 Epilepsy Valproic Acid 6.8920417680 18234410
MESH:D004832 Epilepsy, Absence Phenobarbital 9.286401628
MESH:D004832 Epilepsy, Absence Valproic Acid 9.286254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.907750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.907750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 11.143659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 11.143659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4616530937
MESH:D005234 Fatty Liver pirinixic acid 26.2720131406 19236843
MESH:D005234 Fatty Liver Raloxifene 26.2717473493
MESH:D005234 Fatty Liver Tamoxifen 26.2719224547 14986274
MESH:D005234 Fatty Liver Tetracycline 26.2719224547 16917069
MESH:D005234 Fatty Liver Valproic Acid 26.2719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.298888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005499 Folliculitis Astemizole 6.131671328
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006331 Heart Diseases Raloxifene 3.6311110106
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006529 Hepatomegaly Phenobarbital 9.0716109766
MESH:D006529 Hepatomegaly pirinixic acid 9.0719772884 19176532 18467677 16221962
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Raloxifene 2.9115787275 17577099
MESH:D007249 Inflammation Tamoxifen 2.4219457130
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1618625569
MESH:D007889 Leiomyoma Raloxifene 4.6516973256
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D017513 Lichen Nitidus Astemizole 6.682563723
MESH:D008064 Lipidoses Tamoxifen 3.2515342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3618564211
MESH:D008107 Liver Diseases Acetaminophen 4.0419014921 16610002 19784758 12587719 19460945 16611625 12969438 11587558
MESH:D008107 Liver Diseases Phenobarbital 4.0419363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0920195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 11.0919812893 8742319 19482888 19073162 15975961 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 11.0920007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 11.0916684651
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.7817172636 1399818 18308698 6150874 2563599
MESH:D008133 Long QT Syndrome Astemizole 4.7011989578 18472280
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.406695378 18569708 20135361 18816296 17053015 20064080 18520028 20869020 20464547
MESH:D008175 Lung Neoplasms Tamoxifen 2.4018625569
MESH:D008288 Malaria Astemizole 4.8316816845
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7114580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.7619453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008881 Migraine Disorders Valproic Acid 3.2918765137 18803445
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7715863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma Raloxifene 3.5316497877
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009232 Myxoma Raloxifene 5.7716343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219200415 19189210 19196722
MESH:D009395 Nephritis, Interstitial Tetracycline 5.009884423
MESH:D009436 Neural Tube Defects Valproic Acid 3.218888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009759 Nystagmus, Pathologic Astemizole 6.686135121
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010024 Osteoporosis Raloxifene 3.4717882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3817823083 15579764 15758505 17893378
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5316965848
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.6511026799
MESH:D011230 Precancerous Conditions Phenobarbital 3.752563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0220603192
MESH:D017096 Prion Diseases Tetracycline 5.6110903871
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5517292933
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5516220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5515067354
MESH:D019310 Pseudolymphoma Phenobarbital 12.9312752131
MESH:D019310 Pseudolymphoma Valproic Acid 12.9312752131 11422049
MESH:D011693 Purpura Raloxifene 5.7715770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.6410822083
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures Phenobarbital 6.313137016 11442880 4039156 16876388
MESH:D012640 Seizures Valproic Acid 6.3115475178 14763951 11738929 11044598 1511512 16876388 3137016 17978042
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4310029692 19755658
MESH:D013088 Spermatocele Tamoxifen 4.5116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Raloxifene 3.9316837676
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.161399818
MESH:D013978 Tibial Fractures Raloxifene 5.4319048282
MESH:D016171 Torsades de Pointes Astemizole 5.408256756 9583453
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6417053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.6417572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.6416712894 17572228 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D014581 Urticaria Acetaminophen 9.5410982225
MESH:D014581 Urticaria Astemizole 9.541683191 2568013 2568189 2885854 3080510 2883202 2147912 2565098 1976298 2859714 3097109 3134034
MESH:D054556 Venous Thromboembolism Raloxifene 5.4316837676
MESH:D014717 Vertigo Astemizole 6.683105558
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7716343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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