AutismKB 2.0

Annotation Detail for ATRNL1


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Basic Information Top
Gene Symbol:ATRNL1 ( ALP,FLJ45344,KIAA0534,bA338L11.1,bA454H24.1 )
Gene Full Name: attractin-like 1
Band: 10q25.3
Quick LinksEntrez ID:26033; OMIM: 612869; Uniprot ID:ATRN1_HUMAN; ENSEMBL ID: ENSG00000107518; HGNC ID: 29063
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C447119 bazedoxifene acetate bazedoxifene acetate results in decreased expression of ATRNL1 mRNAdecreases expression 19914376
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ATRNL1 mRNAdecreases expression 17484886
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ATRNL1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of ATRNL1 mRNAincreases expression 19619570
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ATRNL1 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of ATRNL1 mRNAdecreases expression 19482888
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ATRNL1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ATRNL1 mRNAdecreases expression 19619570
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 10.156195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.1515322242 11752688 14514962
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.9517620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.9516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Estradiol 1.9012948864 19861407 16675129 17261762 17018787 14630087 18497071 17289903
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2615721981 16227642 10355542 16124888 18705752 16011737 16050911 16097048 3786805 16192424 15673190 15700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.8418788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8416924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.846705139 17173139 20935162 20007298 1701930
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0018566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2216354765 12621046 8697196 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.7419279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.003786805 7440962 6623471 16177239 17522070 19085960 3732212 15968718 16227642 10915739 9327722 21278145 15027814 2869522 7179309 10092053 15998439 19336974 7120509 4309450 11566570 6884620
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5116714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.2018566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.483922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.5419224547 12795759 16239168 16045604 61145 12631006 17595544 15959796
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Carbon Tetrachloride 10.2618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.2620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 10.1016109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 10.1015340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.6415709030
MESH:D019584 Hot Flashes Estradiol 4.3617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6616959395 15340226 8697196 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.1816627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007674 Kidney Diseases Estradiol 2.7615618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2815610895
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.2117157831 16221502 11903743 17174718 16943688 11408273 21278145 16239168 17334410
MESH:D008103 Liver Cirrhosis Phenobarbital 7.2121047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6116192424 15650968 18339082 16015684 18277467 12649538 17708605 15959796 17805973 16116963 17631135 15925388 12546737 17869086 18251166 18263696 15818738 18054572 12958196 16011737 15362042 17481882 17766677 12666154 17761835 14512876 17922224 15893842 15931870 12389079 18472094 15370692 12741479 12445418 16248980 16136751 18187930 14620537 15673190 17823541 17714472 17698563 12632512 17976157 15123356 17565644 18395914 14716496 18412020 18317297 18210741 18472332 15730626 18006644 12632514 14748882 15996030 17640975 15338365 18481824 18376398 12445421 17557913 17900296 16638106 14724832 12898905 18205269 13678700 16033810 20821823 15052691 18279442 17721639 10355542 12586293 17944888 14716833 18705752 15057751 16027843 18420326 11481614 18156304 12609069 18395095 18429990 12667390 17525996 16097048 18166357 18418968 15876570
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6112878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.3415830285 16964402 17285989 16246199 15720792
MESH:D008107 Liver Diseases Phenobarbital 4.3419363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.0519294768
MESH:D008113 Liver Neoplasms Phenobarbital 8.0515975961 19812893 21047994 19073162 19482888 8742319
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 11.0212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 11.021399818 18308698 17172636 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.0212151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7717203775 11408345 16891317 11807958
MESH:D020149 Manganese Poisoning Estradiol 5.0919453300
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5516810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009389 Neovascularization, Pathologic Estradiol 4.2717289903
MESH:D009421 Nervous System Malformations Estradiol 10.9711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.9714600291
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.3019401270
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5916965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.952563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311222880 11896295 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0316740699
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012640 Seizures Phenobarbital 2.9216876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.321399818
MESH:D013978 Tibial Fractures Estradiol 5.3019048282
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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