AutismKB 2.0

Annotation Detail for SIPA1L1


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Basic Information Top
Gene Symbol:SIPA1L1 ( DKFZp686G1344,E6TP1,KIAA0440 )
Gene Full Name: signal-induced proliferation-associated 1 like 1
Band: 14q24.1
Quick LinksEntrez ID:26037; OMIM: NA; Uniprot ID:SI1L1_HUMAN; ENSEMBL ID: ENSG00000197555; HGNC ID: 20284
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SIPA1L1 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SIPA1L1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SIPA1L1 mRNAdecreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SIPA1L1 mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SIPA1L1 mRNAaffects expression 17484886
D005419 Flavonoids Flavonoids results in increased expression of SIPA1L1 mRNAincreases expression 18035473
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SIPA1L1 mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SIPA1L1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of SIPA1L1 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in increased expression of SIPA1L1 mRNAincreases expression 18037150
D018038 Sodium Selenite Sodium Selenite results in increased expression of SIPA1L1 mRNAincreases expression 18175754
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SIPA1L1 mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of SIPA1L1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.648875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D001008 Anxiety Disorders Valproic Acid 9.1517497229
MESH:D001008 Anxiety Disorders vinclozolin 9.1519015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001321 Autistic Disorder Valproic Acid 2.0020603192 18316065 18940202 17507914 18775368 15238991 18177632 18985861 19460635 17688650 17157402 18558336 19232924 16609825 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.1320046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.478888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5117868700
MESH:D001930 Brain Injuries Progesterone 4.4015665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1620146248 17474063
MESH:D001943 Breast Neoplasms Progesterone 2.1617614352 15562024 16175315
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9216227642 3786805 18705752 10355542 15700767 16011737 15673190 16050911 16124888 16192424 16097048 15721981
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0316705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0318788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 17688650 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D003929 Diabetic Neuropathies Progesterone 4.6317187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.264309450 3732212 16227642 6623471 10092053 7120509 2869522 19085960 10915739 15998439 9327722 3786805 15027814 16177239 6884620 7440962 21278145 11566570 7179309 19336974 17522070 15968718
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.2615131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.261733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.171851702
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9117692515
MESH:D004715 Endometriosis Progesterone 3.8716134523
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.293659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9918234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.687562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.223659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.7616045604 17595544 12795759 16239168 15959796 12631006 19224547 61145
MESH:D005234 Fatty Liver pirinixic acid 13.7620131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 13.7619224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2618558336 8888407
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5918705752
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.1316221962 18467677 19176532 19772884
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7616612254
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5415869954
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007249 Inflammation Flavonoids 5.4517296493
MESH:D007249 Inflammation Progesterone 5.4515869954
MESH:D007333 Insulin Resistance pirinixic acid 7.5416306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.5414714311
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.0616705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8611408273 21278145 16943688 16221502 11903743 17157831 16239168 17334410 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3515876570 12445418 17631135 17708605 14716496 12632514 12632512 15338365 16192424 10355542 12445421 12546737 15123356 12741479 18395095 17761835 17944888 18251166 18472332 17714472 18317297 18054572 12609069 16248980 12649538 18376398 15057751 15996030 18705752 18395914 16116963 18210741 17823541 15818738 18277467 14620537 18263696 12586293 17565644 15730626 15959796 18412020 17922224 18279442 18481824 17805973 18166357 15673190 15925388 17721639 16011737 12898905 15052691 17557913 14716833 18006644 16097048 18205269 17766677 18429990 18472094 16027843 17525996 16015684 15362042 18187930 18339082 13678700 17900296 18156304 12958196 16033810 17976157 18420326 12667390 15370692 17481882 16638106 11481614 12666154 17869086 17698563 18418968 20821823 14748882 15931870 17640975 15650968 14512876 15893842 14724832 16136751 12389079
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3515474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1016246199 17285989 15720792 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7916899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6020195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.6019294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.6016377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6815583823 12014681
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5618520028 20064080 17053015 18569708 18816296 6695378 20464547 20135361 20869020
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9311408345 17203775
MESH:D008881 Migraine Disorders Valproic Acid 3.2718803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.208888407 16359493
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5316049721 12819281
MESH:D010051 Ovarian Neoplasms Progesterone 2.5516525653 17393432
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.2420603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.2418220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2017292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2018760546
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.7112752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2919155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8918045962
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1918551238
MESH:D012640 Seizures Valproic Acid 6.1911738929 3137016 15475178 14763951 17978042 11044598 16876388 1511512
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8710029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.878532709
MESH:D013119 Spinal Cord Injuries Progesterone 4.4315862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1017053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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