AutismKB 2.0

Annotation Detail for PPP1R16B


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Basic Information Top
Gene Symbol:PPP1R16B ( ANKRD4,KIAA0823,TIMAP )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 16B
Band: 20q11.23
Quick LinksEntrez ID:26051; OMIM: 613275; Uniprot ID:PP16B_HUMAN; ENSEMBL ID: ENSG00000101445; HGNC ID: 15850
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of PPP1R16B mRNAaffects cotreatment|decreases expression 17404688
D007501 Iron Iron deficiency results in increased expression of PPP1R16B mRNAincreases expression 20368581
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of PPP1R16B mRNAaffects cotreatment|decreases expression 17404688
D013654 Taurine Taurine results in increased expression of PPP1R16B mRNAincreases expression 16579726
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1711473722
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 6.2816640825
MESH:D000544 Alzheimer Disease Iron 3.0716640825 16563566
MESH:D000740 Anemia Iron 4.7616434484 16566752
MESH:D018798 Anemia, Iron-Deficiency Iron 5.0417162259 17375513 16569441 17163184 17147795
MESH:D000756 Anemia, Sideroblastic Iron 5.2416910769
MESH:D001145 Arrhythmias, Cardiac Iron 4.7616604332
MESH:D001260 Ataxia Telangiectasia Iron 6.0815336622
MESH:D050197 Atherosclerosis Iron 3.9216640825 16632123
MESH:D001321 Autistic Disorder Iron 2.7717352947
MESH:D001424 Bacterial Infections Iron 5.8316640825
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 6.0617868700
MESH:D001930 Brain Injuries Progesterone 4.8215845082 15380490 15665606
MESH:D001943 Breast Neoplasms Estradiol 2.1717261762 12948864 17018787 17289903 14630087 16675129 19861407 18497071
MESH:D001943 Breast Neoplasms Progesterone 2.1717614352 15562024 16175315
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0916111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7916924424
MESH:D009202 Cardiomyopathies Iron 4.2916640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.5616604332
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0318566989
MESH:D003110 Colonic Neoplasms Iron 2.9416640825
MESH:D003920 Diabetes Mellitus Iron 4.8216604332 16640825
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.4516506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 3.1616506275
MESH:D058065 Diabetic Cardiomyopathies Taurine 6.6816025228
MESH:D003928 Diabetic Nephropathies Estradiol 3.7819279558
MESH:D003929 Diabetic Neuropathies Progesterone 5.0517187935
MESH:D056486 Drug-Induced Liver Injury Taurine 3.649328219
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.2817692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.2211473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 4.1616134523
MESH:D005234 Fatty Liver Iron 4.5116640825
MESH:D005621 Friedreich Ataxia Iron 5.9916604332 16640825
MESH:D006432 Hemochromatosis Iron 4.7717236123 16640825 16574947 17255318 17053826 16604332
MESH:D006486 Hemosiderosis Iron 5.9416604332
MESH:D006525 Hepatitis, Viral, Human Iron 6.1916640825
MESH:D006527 Hepatolenticular Degeneration Iron 5.5017182432
MESH:D006529 Hepatomegaly Iron 4.8716890145
MESH:D006558 Herpes Genitalis Estradiol 5.7615709030
MESH:D015658 HIV Infections Iron 3.8516597321
MESH:D019584 Hot Flashes Estradiol 4.4717088409
MESH:D007006 Hypogonadism Iron 4.6716640825
MESH:D007037 Hypothyroidism Iron 5.6416640825
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.9615869954
MESH:D007249 Inflammation Progesterone 2.7715869954
MESH:D007333 Insulin Resistance Estradiol 3.2116627594 16393666
MESH:D019189 Iron Metabolism Disorders Iron 5.5017163184
MESH:D007674 Kidney Diseases Estradiol 2.7815618244
MESH:D007680 Kidney Neoplasms Estradiol 3.3215610895
MESH:D020961 Lewy Body Disease Iron 5.9916563566
MESH:D008103 Liver Cirrhosis Iron 3.9116640825
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.1014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Taurine 3.1015931870 15893842
MESH:D008108 Liver Diseases, Alcoholic Iron 5.5716737972 17207112
MESH:D008113 Liver Neoplasms Iron 3.2520302851 16640825
MESH:D008175 Lung Neoplasms Iron 2.6716640825
MESH:D008268 Macular Degeneration Iron 4.1716640825
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.8611807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.8617203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.2119453300
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 6.3917086897
MESH:D009181 Mycoses Iron 6.1916640825
MESH:D017202 Myocardial Ischemia Iron 4.7716604332
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.7816810080
MESH:D015428 Myocardial Reperfusion Injury Iron 9.7816604332
MESH:D009389 Neovascularization, Pathologic Estradiol 4.3617289903
MESH:D009404 Nephrotic Syndrome Iron 4.8817178036
MESH:D009421 Nervous System Malformations Estradiol 4.1616427766 11399458
MESH:D019636 Neurodegenerative Diseases Iron 4.5917296847 16604332
MESH:D010003 Osteoarthritis Iron 4.1816640825
MESH:D010024 Osteoporosis Iron 4.0816648989 16640825
MESH:D010051 Ovarian Neoplasms Estradiol 5.2019401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.2017393432 16525653
MESH:D010212 Papilloma Iron 5.0412065085
MESH:D020447 Parasomnias Iron 6.7417352947
MESH:D010300 Parkinson Disease Iron 3.4316563566 16640825
MESH:D010900 Pituitary Diseases Iron 6.3916604332
MESH:D011041 Poisoning Iron 4.7516604332
MESH:D017119 Porphyria Cutanea Tarda Iron 5.4916640825
MESH:D011225 Pre-Eclampsia Iron 4.7316640825
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0216740699
MESH:D011528 Protozoan Infections Iron 6.7416640825
MESH:D012148 Restless Legs Syndrome Iron 4.8416930377
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9618045962
MESH:D012878 Skin Neoplasms Iron 3.6212065085
MESH:D013119 Spinal Cord Injuries Progesterone 4.9116503802 15862959
MESH:D013398 Sudden Infant Death Iron 6.0816640825
MESH:D013978 Tibial Fractures Estradiol 5.4119048282
MESH:D014376 Tuberculosis Iron 4.3116597321
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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