AutismKB 2.0

Annotation Detail for AUTS2


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Basic Information Top
Gene Symbol:AUTS2 ( FBRSL2,KIAA0442,MGC13140 )
Gene Full Name: autism susceptibility candidate 2
Band: 7q11.22
Quick LinksEntrez ID:26053; OMIM: 607270; Uniprot ID:AUTS2_HUMAN; ENSEMBL ID: ENSG00000158321; HGNC ID: 14262
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic affects the expression of AUTS2 mRNAaffects expression 18414638
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AUTS2 mRNAdecreases expression 20382639
19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of AUTS2 mRNAdecreases expression 15336504
C459604 candoxin candoxin results in increased expression of AUTS2 mRNAincreases expression 16309724
D016572 Cyclosporine Cyclosporine results in decreased expression of AUTS2 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of AUTS2 mRNAdecreases expression 20068009
D010656 Phenylephrine Phenylephrine results in decreased expression of AUTS2 mRNAdecreases expression 18158353
C024746 tobacco tar tobacco tar results in decreased expression of AUTS2 mRNAdecreases expression 19559774
D019772 Topotecan AUTS2 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014212 Tretinoin Tretinoin results in increased expression of AUTS2 mRNAincreases expression 18230668
D014635 Valproic Acid Valproic Acid results in decreased expression of AUTS2 mRNAdecreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of AUTS2 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of AUTS2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.608875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3517306315
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D001008 Anxiety Disorders Valproic Acid 9.0717497229
MESH:D001008 Anxiety Disorders vinclozolin 9.0719015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1917460149
MESH:D020261 Arsenic Poisoning Arsenic 2.8912569548 16251483 18414634 16835338
MESH:D001169 Arthritis, Experimental Tretinoin 3.1216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D050197 Atherosclerosis Arsenic 3.2912928151 19371607
MESH:D001321 Autistic Disorder Valproic Acid 2.0020603192 16609825 17507914 19232924 15238991 18558336 18316065 18940202 17157402 18177632 18396377 19460635 17688650 18775368 18985861
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.1117594078 20046352
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6916206674 16197459
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.458888407
MESH:D001919 Bradycardia Phenylephrine 4.6615306635
MESH:D001943 Breast Neoplasms Estradiol 2.1418497071 19861407 17018787 17289903 14630087 17261762 12948864 16675129
MESH:D001943 Breast Neoplasms Tretinoin 2.1416166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6315504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.7116507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.711917145
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.8718922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8716096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1518640142
MESH:D006332 Cardiomegaly Phenylephrine 3.5717287366 15728586 16170337 11754973 11179087 17124262
MESH:D002318 Cardiovascular Diseases Arsenic 3.5019152805 15738583 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.3818022660 16973168
MESH:D002386 Cataract Tretinoin 3.1417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.5320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.5312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.5318566989
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 16.5319559774
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D002779 Cholestasis Cyclosporine 2.9719486331
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tretinoin 2.709407595
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.8910589399 8800419 17551590 9142499 9125849 16925845 9664655 9211117 14991402 9224671
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.8916575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8919769572
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.1919641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.141851702
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004489 Edema, Cardiac Tretinoin 4.6018230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.5911473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.5916569247
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.2617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.053922381 16628512
MESH:D004827 Epilepsy marker/mechanism 20502679
MESH:D004827 Epilepsy Valproic Acid 2.9718234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.667562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.407750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.183659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0920426865
MESH:D005124 Eye Abnormalities Tretinoin 3.6416938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 8.0319224547
MESH:D005234 Fatty Liver Valproic Acid 8.0319224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.238888407 18558336
MESH:D005355 Fibrosis Cyclosporine 9.0412168785 12639820
MESH:D005355 Fibrosis Tretinoin 9.0417994277
MESH:D005534 Foot Diseases Arsenic 5.696392382
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma Tretinoin 3.0517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Tretinoin 6.9114991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9116080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 10.5017088409
MESH:D019584 Hot Flashes Vitamin E 10.5014716179
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006930 Hyperalgesia Tretinoin 3.2816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5317050553
MESH:D006973 Hypertension Arsenic 8.9116076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 8.9110903974
MESH:D006973 Hypertension Phenylephrine 8.918949925 12717712
MESH:D006984 Hypertrophy Phenylephrine 4.6312791704 18502941
MESH:D006987 Hypesthesia Arsenic 5.6916093927
MESH:D007248 Infertility, Male vinclozolin 3.0916467254
MESH:D007251 Influenza, Human Vitamin E 4.3516624496
MESH:D007333 Insulin Resistance Estradiol 3.0216393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9817551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007642 Keratosis Arsenic 5.1112749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 10.3218776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 10.3215618244
MESH:D007674 Kidney Diseases Vitamin E 10.3212488133
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5012371664
MESH:D007680 Kidney Neoplasms Estradiol 7.5015610895
MESH:D007938 Leukemia Tretinoin 2.8117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7816932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9317596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9317596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.9317339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.9317339181 17712046 19075265 16331271 17107899 16140955 16788101 16766008 17294898 17368321 19035177 19642359 9834237 15748426 17506722 17217047 12679006 16935935 17649720 16891316 19029980 16823087 19225113 17361223 17301526
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5816248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5816169303
MESH:D008107 Liver Diseases Arsenic 2.5611134558
MESH:D008113 Liver Neoplasms Arsenic 2.7116368122
MESH:D008171 Lung Diseases Vitamin E 3.2316863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4017228818
MESH:D008175 Lung Neoplasms Arsenic 2.6817306315 17976673 19168569
MESH:D008175 Lung Neoplasms Vitamin E 2.6811062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6111807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2518765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.5417596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.5417596541
MESH:D017202 Myocardial Ischemia Arsenic 4.0515371236
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009369 Neoplasms Tretinoin 2.4416594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.9911399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 9.999125849
MESH:D009436 Neural Tube Defects Arsenic 12.5016620997
MESH:D009436 Neural Tube Defects Tretinoin 12.509142499
MESH:D009436 Neural Tube Defects Valproic Acid 12.508888407 16359493
MESH:D009447 Neuroblastoma Topotecan 3.8915176712
MESH:D020078 Neurogenic Inflammation Arsenic 4.4617056641
MESH:D010051 Ovarian Neoplasms Arsenic 8.0617306315
MESH:D010051 Ovarian Neoplasms Estradiol 8.0619401270
MESH:D010051 Ovarian Neoplasms Tretinoin 8.0616936753
MESH:D010146 Pain Tretinoin 2.9716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4915976015
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.2716093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.116392382 15371236 16905509
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.1220603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.1218220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.6016140617
MESH:D011471 Prostatic Neoplasms Estradiol 2.6016740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6015084515
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D011507 Proteinuria Arsenic 9.5721343184
MESH:D011507 Proteinuria Tretinoin 9.5716636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.6711422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.1616283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.1619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Valproic Acid 2.7911738929 17978042 16876388 15475178 11044598 3137016 1511512 14763951
MESH:D012852 Sinusitis Phenylephrine 4.827327846
MESH:D012871 Skin Diseases Arsenic 5.1016353154 19834688 17938729 18709164 15952646 17453740 6392382 17050553 16702368 17548696 16759981
MESH:D012871 Skin Diseases Vitamin E 5.1018709164
MESH:D012878 Skin Neoplasms Arsenic 9.7717029826 15504454 17050553 19538983 16251483 17976673
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.778532709
MESH:D012878 Skin Neoplasms Tretinoin 9.7716467112
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0916026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8411144890 18640142 19322015 19429237 17976673 17306315 15987713
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7516129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D014652 Vascular Diseases Arsenic 4.8517056641
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134863175
    • No data
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    PA447216Schizophrenia
    PA153906318Autism Spectrum Disorder
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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