AutismKB 2.0

Annotation Detail for SENP6


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Basic Information Top
Gene Symbol:SENP6 ( FLJ11355,FLJ11887,KIAA0389,KIAA0797,SSP1,SUSP1 )
Gene Full Name: SUMO1/sentrin specific peptidase 6
Band: 6q14.1
Quick LinksEntrez ID:26054; OMIM: 605003; Uniprot ID:SENP6_HUMAN; ENSEMBL ID: ENSG00000112701; HGNC ID: 20944
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SENP6 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SENP6 mRNAdecreases expression 20064835
D003010 Clorgyline Clorgyline results in increased expression of SENP6 mRNAincreases expression 19691856
D016572 Cyclosporine Cyclosporine results in increased expression of SENP6 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SENP6 mRNAaffects cotreatment|increases expression 17942748
C051890 irinotecan irinotecan analog results in decreased expression of SENP6 mRNAdecreases expression 18927307
D008628 Mercury Mercury results in increased expression of SENP6 mRNAincreases expression 16823088
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SENP6 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3520127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3514692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Mercury 2.7717497416
MESH:D001327 Autoimmune Diseases Mercury 5.1816634805
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8720146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7816705839
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.5210334427
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.116135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1112371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Cyclosporine 8.3719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3717333356 16919318 11677210 17681005 17110522 16105132 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 15668235 8697196 12621046 15340226
MESH:D003110 Colonic Neoplasms irinotecan 2.6217725105 17287894
MESH:D015179 Colorectal Neoplasms irinotecan 2.3615273666 18259882 17454858 17159606 16303861 18509181 16391804
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D017449 Dermatitis, Allergic Contact Mercury 4.0916823706
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.8921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Cyclosporine 8.4019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.4015345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Cyclosporine 9.5212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8211294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 16354765 15340226 16959395 8697196
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.7210903974 18776723 8314463
MESH:D007674 Kidney Diseases Mercury 6.7217934191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.827678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8221137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.206135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2012151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2417053015 18569708 20869020 18816296 20064080 6695378 18520028 20135361 20464547
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2419555203 11884234
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D052016 Mucositis irinotecan 5.3517159606
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.207678174 18551238
MESH:D009362 Neoplasm Metastasis irinotecan 3.2518259882
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009447 Neuroblastoma irinotecan 3.598761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.078761367
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.5017292933
MESH:D011471 Prostatic Neoplasms Clorgyline 3.5019691856
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.6020155912 2093021
MESH:D013274 Stomach Neoplasms irinotecan 2.6015723263
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2417053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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