Annotation Detail for APPL1
Basic Information
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| Gene Symbol: | APPL1 ( APPL,DIP13alpha ) |
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| Gene Full Name: | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 |
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| Band: | 3p14.3 |
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| Quick Links | Entrez ID:26060; OMIM: 604299; Uniprot ID:DP13A_HUMAN; ENSEMBL ID: ENSG00000157500; HGNC ID: 24035 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| Apoptosis |
| Pathway ID | Pathway Name |
|---|
| 200038 | Coregulation of Androgen receptor activity |
| Pathway ID | Pathway Name |
|---|
| 500280 | Role of DCC in regulating apoptosis |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of APPL1 mRNA | affects expression | 17562736
|
| D020122 |
tert-Butylhydroperoxide |
tert-Butylhydroperoxide results in decreased expression of APPL1 mRNA | decreases expression | 15336504
|
| D004997 |
Ethinyl Estradiol |
Ethinyl Estradiol results in increased expression of APPL1 mRNA | increases expression | 17555576
|
| D014501 |
Uranium |
Uranium affects the expression of APPL1 mRNA | affects expression | 15672453
|
| C005460 |
uranyl acetate |
uranyl acetate affects the expression of APPL1 mRNA | affects expression | 15672453
|
| C025643 |
vinclozolin |
vinclozolin affects the expression of APPL1 mRNA | affects expression | 19015723
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000152 |
Acne Vulgaris |
|
Ethinyl Estradiol |
4.46 | 17505938 |
| MESH:D000230 |
Adenocarcinoma |
|
Ethinyl Estradiol |
1.87 | 14692618 |
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.36 | 10982225 |
| MESH:D001008 |
Anxiety Disorders |
|
vinclozolin |
3.89 | 19015723 |
| MESH:D001161 |
Arteriosclerosis |
|
Ethinyl Estradiol |
3.88 | 11256880 |
| MESH:D001169 |
Arthritis, Experimental |
|
Ethinyl Estradiol |
2.84 | 15885639 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.40 | 18445737 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
1.40 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.75 | 10977129 |
| MESH:D002779 |
Cholestasis |
|
Ethinyl Estradiol |
3.10 | 17333356 17681005 11677210 16105132 15861022 16919318 17110522 |
| MESH:D003456 |
Cryptorchidism |
|
vinclozolin |
4.72 | 14966744 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
1.65 | 12392966 11461765 11529661 11743745 16393943 17906064 19370779 16781746 10663392 18713872 15619225 14725611 17562736 19739265 16485898 11287661 10774834 18071297 14550746 11739529 19420014 16109766 12153990 19416960 12540782 12705907 19923254 16081117 14986274 10915739 17522070 16227642 12958197 19085960 11421492 12594235 2444490 15968718 11834606 16177239 19164858 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.62 | 19426721 |
| MESH:D004681 |
Encephalomyelitis, Autoimmune, Experimental |
|
Ethinyl Estradiol |
3.57 | 12538720 |
| MESH:D005234 |
Fatty Liver |
|
Ethinyl Estradiol |
3.14 | 15345470 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.19 | 16983495 |
| MESH:D030342 |
Genetic Diseases, Inborn |
|
vinclozolin |
5.40 | 16973722 |
| MESH:D005832 |
Genital Diseases, Male |
|
vinclozolin |
5.82 | 16417039 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
2.95 | 16870215 |
| MESH:D007021 |
Hypospadias |
|
Ethinyl Estradiol |
4.23 | 16945680 16569931 |
| MESH:D007247 |
Infertility, Female |
|
Ethinyl Estradiol |
3.81 | 12013081 |
| MESH:D007248 |
Infertility, Male |
|
Ethinyl Estradiol |
7.33 | 17937319 |
| MESH:D007248 |
Infertility, Male |
|
vinclozolin |
7.33 | 16467254 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
2.36 | 15629191 12587719 |
| MESH:D007984 |
Leydig Cell Tumor |
|
vinclozolin |
5.19 | 16417039 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.69 | 19784758 12969438 11587558 16611625 19460945 12587719 19014921 16610002 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.54 | 16871587 17185352 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
3.98 | 19513568 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.14 | 18514411 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.65 | 16870215 |
| MESH:D016584 |
Panic Disorder |
|
Ethinyl Estradiol |
4.04 | 11578682 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
vinclozolin |
4.36 | 18042343 19015723 18220299 |
| MESH:D011469 |
Prostatic Diseases |
|
vinclozolin |
5.40 | 18220299 |
| MESH:D011472 |
Prostatitis |
|
vinclozolin |
5.40 | 18629315 |
| MESH:D011537 |
Pruritus |
|
Ethinyl Estradiol |
3.77 | 16919318 15861022 |
| MESH:D012878 |
Skin Neoplasms |
|
tert-Butylhydroperoxide |
2.81 | 8532709 |
| MESH:D013088 |
Spermatocele |
|
Ethinyl Estradiol |
4.46 | 16709447 |
| MESH:D019851 |
Thrombophilia |
|
Ethinyl Estradiol |
3.97 | 11994571 |
| MESH:D013927 |
Thrombosis |
|
Ethinyl Estradiol |
3.44 | 15669648 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.33 | 10982225 |
| MESH:D014594 |
Uterine Neoplasms |
|
Ethinyl Estradiol |
3.68 | 14692618 |
| MESH:D020246 |
Venous Thrombosis |
|
Ethinyl Estradiol |
3.87 | 14671159 15869587 |
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