AutismKB 2.0

Annotation Detail for DECR2


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Basic Information Top
Gene Symbol:DECR2 ( PDCR,SDR17C1 )
Gene Full Name: 2,4-dienoyl CoA reductase 2, peroxisomal
Band: 16p13.3
Quick LinksEntrez ID:26063; OMIM: NA; Uniprot ID:DECR2_HUMAN; ENSEMBL ID: ENSG00000103202,ENSG00000242612; HGNC ID: 2754
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DECR2 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of DECR2 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of DECR2 mRNAdecreases expression 18346771
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DECR2 mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in increased expression of DECR2 mRNAincreases expression 16648578
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of DECR2 mRNAdecreases expression 18346771
D002995 Clofibric Acid Clofibric Acid affects the expression of DECR2 mRNAaffects expression 17602206
C057862 cyanoginosin LR cyanoginosin LR results in decreased expression of DECR2 mRNAdecreases expression 17383702
D016572 Cyclosporine Cyclosporine results in decreased expression of DECR2 mRNAdecreases expression 20106945
C121718 dicyclanil dicyclanil results in increased expression of DECR2 mRNAincreases expression 15664270
D004041 Dietary Fats Dietary Fats results in increased expression of DECR2 mRNAincreases expression 16357043
D005419 Flavonoids Flavonoids results in increased expression of DECR2 mRNAincreases expression 18035473
D005912 Gliotoxin Gliotoxin results in decreased expression of DECR2 mRNAdecreases expression 18346771
D005978 Glutathione Glutathione deficiency results in increased expression of DECR2 mRNAincreases expression 15345336
C482199 lipopolysaccharide, E coli O55-B5 lipopolysaccharide, E coli O55-B5 results in decreased expression of DECR2 mRNAdecreases expression 18346771
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of DECR2 mRNAincreases expression 18467677
17681415
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of DECR2 mRNA]increases expression|increases reaction 18467677
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of DECR2 mRNAincreases expression 16221955
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DECR2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of DECR2 mRNAincreases expression 16357043
18301758
18467677
17426115
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of DECR2 mRNA]increases expression|increases reaction 18467677
C006253 pirinixic acid pirinixic acid results in increased expression of DECR2 mRNAincreases expression 16940010
D012643 Selenium Selenium deficiency results in increased expression of DECR2 mRNAincreases expression 16170372
D014284 Triiodothyronine Triiodothyronine results in increased expression of DECR2 mRNAincreases expression 15953391
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of DECR2 mRNAaffects cotreatment|decreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.713712494
MESH:D018248 Adenoma, Liver Cell dicyclanil 17.0917162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.0916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.0916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D001161 Arteriosclerosis Dietary Fats 3.8215238619
MESH:D001321 Autistic Disorder Acetaminophen 2.2218445737
MESH:D001321 Autistic Disorder Glutathione 2.2219056591 18929414 19267885 16917939
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.961440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.5619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001943 Breast Neoplasms bexarotene 1.9416344269 16818667
MESH:D001943 Breast Neoplasms Dietary Fats 1.9420435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7216097048 16227642 18705752 15673190 3786805 16192424 16011737 15721981 16124888 15700767 10355542 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.523581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.523084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.5218788625
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 6.5217162532
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2016247446
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.647296757
MESH:D002294 Carcinoma, Squamous Cell Glutathione 3.3517015178
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.5410977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.427505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.4212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.0919486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.0919486331
MESH:D002779 Cholestasis pirinixic acid 13.0919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815340226 12621046 8697196 15668235 16354765
MESH:D003092 Colitis Selenium 3.7217936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0017141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003550 Cystic Fibrosis Glutathione 4.4319747007
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7414531868 8156756 2524372 18759878 11906362 12868966 11298694 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.433621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 18.419653073 18692083 1440618 9022650 9328219 8291058 6482804 18289764 18648102 16192314 11289319 7440962 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.4119739265 16081117 16781746 11421492 11739529 19085960 19416960 15968718 11461765 16177239 18713872 17906064 14725611 18071297 16227642 12958197 19164858 12705907 12153990 10915739 16485898 16109766 12540782 11287661 10774834 17522070 15619225 10663392 19923254 16393943 19370779 2444490 17562736 11529661 12594235 12392966 19420014 11743745 14550746 11834606 14986274
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 18.4116177239 19336974 4309450 11566570 7440962 10915739 16227642 7120509 2869522 3786805 19085960 6884620 9327722 7179309 15968718 6623471 17522070 15998439 21278145 15027814 3732212 10092053
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 18.4117654400
MESH:D056486 Drug-Induced Liver Injury Gliotoxin 18.4119739265
MESH:D056486 Drug-Induced Liver Injury Selenium 18.4115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.4120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4018367378
MESH:D004487 Edema perfluorooctanoic acid 11.1117259670 12083418
MESH:D004487 Edema pirinixic acid 11.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.1112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8515322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9610568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.093581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.2512631006 16045604 16239168 19224547 15959796 17595544 61145 12795759
MESH:D005234 Fatty Liver Cyclosporine 18.2519224547
MESH:D005234 Fatty Liver Dietary Fats 18.2517967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver pirinixic acid 18.2519236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.966705139
MESH:D005355 Fibrosis Carbon Tetrachloride 20.6218705752
MESH:D005355 Fibrosis Cyclosporine 20.6212168785 12639820
MESH:D005355 Fibrosis Dietary Fats 20.6218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.6220067830
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.977505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3010048152 11294989
MESH:D006333 Heart Failure pirinixic acid 6.8120558911
MESH:D006333 Heart Failure Selenium 6.8117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.016705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.0119900420 19110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 14.103609246
MESH:D006529 Hepatomegaly pirinixic acid 14.1016221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.1015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9915340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.6816870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.6812083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5521332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8815034207
MESH:D006973 Hypertension Cyclosporine 4.8610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0215338365
MESH:D007249 Inflammation Dietary Fats 11.7120412841
MESH:D007249 Inflammation Flavonoids 11.7117296493
MESH:D007249 Inflammation perfluorooctanoic acid 11.7112083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.7112878042 12200463
MESH:D007251 Influenza, Human Selenium 4.1416624496
MESH:D007333 Insulin Resistance Dietary Fats 7.1018457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.1016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.969022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007674 Kidney Diseases Acetaminophen 5.6715629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.6710903974 8314463 18776723
MESH:D007676 Kidney Failure, Chronic Selenium 3.8216518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.086582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.0812371664
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.178812269
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.5116943688 16221502 11408273 16239168 17334410 21278145 17174718 17157831 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 6.5118296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.159327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.3417869086 17631135 18472332 15876570 17900296 16192424 18054572 17805973 18395095 18418968 18420326 15730626 12609069 18395914 16638106 12632512 12389079 18156304 17823541 15673190 18251166 15338365 18376398 18210741 15931870 12546737 18277467 17640975 17698563 13678700 16011737 17525996 18006644 18412020 17976157 12667390 12898905 16248980 12445418 12445421 16136751 17766677 17481882 18187930 15959796 17944888 14748882 16116963 17708605 15057751 18263696 18705752 12666154 18429990 17922224 14724832 15925388 15996030 14512876 16033810 14716496 12958196 14716833 17721639 18472094 16097048 17557913 15893842 12649538 15650968 15818738 12741479 12632514 11481614 16015684 16027843 15370692 20821823 17714472 18205269 17761835 18339082 14620537 15362042 12586293 15123356 18279442 10355542 15052691 18166357 18481824 17565644 18317297
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3412878042
MESH:D008107 Liver Diseases Acetaminophen 3.8419784758 16611625 11587558 12969438 19460945 12587719 16610002 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.8416964402 16246199 15720792 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.2116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.2114706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.6819294768
MESH:D008113 Liver Neoplasms Clofibric Acid 17.6817602206
MESH:D008113 Liver Neoplasms dicyclanil 17.6820118626
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 17.6814757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 17.6816377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.6816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.546587162 598648 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.5412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.5412151625
MESH:D008175 Lung Neoplasms bexarotene 2.5217849452
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5219555203 11884234
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.0811161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 6.1919196722 15591091 19196723
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.1915318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008654 Mesothelioma Selenium 2.7715107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8916411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.443581430
MESH:D009369 Neoplasms pirinixic acid 1.9217405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.7319196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2319348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.876679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.899802331
MESH:D009765 Obesity Dietary Fats 4.3820132043 21332399 19632207 16723640 18674790 18457598 11836018 17217161 20518802
MESH:D009765 Obesity pirinixic acid 4.3820558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.364026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.963988306
MESH:D010146 Pain Acetaminophen 2.3416870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.427296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.416228378
MESH:D010954 Plasmacytoma Selenium 4.8315087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1612371664
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.4717132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4711222880 11399792 11896295 11118676
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.323692021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0116192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.837505956 6582329 6587162 1399818 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.258074119
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D015430 Weight Gain Dietary Fats 3.6816723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
Pathway ID Pathway Name
KEGG:04146 Peroxisome
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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