AutismKB 2.0

Annotation Detail for RAI14


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Basic Information Top
Gene Symbol:RAI14 ( DKFZp564G013,KIAA1334,NORPEG,RAI13 )
Gene Full Name: retinoic acid induced 14
Band: 5p13.2
Quick LinksEntrez ID:26064; OMIM: 606586; Uniprot ID:RAI14_HUMAN; ENSEMBL ID: ENSG00000039560; HGNC ID: 14873
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
left ventricular mass
Desease Name
Left ventricular mass
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RAI14 mRNAaffects expression 17562736
D001151 Arsenic Arsenic results in decreased expression of RAI14 mRNAdecreases expression 19654921
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RAI14 mRNAdecreases expression 20064835
D004041 Dietary Fats Dietary Fats results in decreased expression of RAI14 mRNAdecreases expression 18042831
D004958 Estradiol Estradiol affects the expression of RAI14 mRNAaffects expression 14699072
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of RAI14 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of RAI14 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAI14 mRNAaffects cotreatment|increases expression 17942748
D007657 Ketone Bodies Ketone Bodies results in decreased expression of RAI14 mRNAdecreases expression 16807920
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of RAI14 mRNAincreases expression 16966085
D009151 Mustard Gas Mustard Gas affects the expression of RAI14 mRNAaffects expression 15651846
C041786 palm oil palm oil results in decreased expression of RAI14 mRNAdecreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased expression of RAI14 mRNAincreases expression 18158353
C006253 pirinixic acid pirinixic acid results in increased expression of RAI14 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of RAI14 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RAI14 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAI14 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RAI14 mRNAincreases expression 19465110
D019772 Topotecan RAI14 protein affects the susceptibility to Topotecanaffects response to substance 16217747
C025643 vinclozolin vinclozolin affects the expression of RAI14 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of RAI14 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8715322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0120464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 7.0111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0114692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.656695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9716835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.2417306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6419015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1117460149
MESH:D020261 Arsenic Poisoning Arsenic 2.8712569548 16251483 18414634 16835338
MESH:D001161 Arteriosclerosis Dietary Fats 9.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001249 Asthma Mustard Gas 2.7110378619
MESH:D050197 Atherosclerosis Arsenic 3.2512928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001768 Blister Mustard Gas 5.1819167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001919 Bradycardia Phenylephrine 4.5615306635
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9220146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.9220435547
MESH:D001943 Breast Neoplasms Estradiol 1.9218497071 17261762 16675129 19861407 14630087 17289903 17018787 12948864
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0117687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9416050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5917687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.583084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.5817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5816924424
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.7215504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7220419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.0818640142
MESH:D006332 Cardiomegaly Phenylephrine 6.8911179087 15728586 11754973 16170337 17287366 17124262
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8918850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.4515738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.3118022660 16973168
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.7718566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7511677210 16105132 17333356 15861022 17681005 17110522 16919318
MESH:D002779 Cholestasis pirinixic acid 7.7519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1016354765 15340226 15668235 8697196 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.4819769572
MESH:D003456 Cryptorchidism vinclozolin 4.3514966744
MESH:D003704 Dementia Methylmercury Compounds 5.0016140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4119279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.5611287661 17562736 11834606 12594235 11421492 18071297 12958197 12392966 10774834 11739529 17522070 10663392 16227642 11461765 16081117 16485898 14986274 11743745 16109766 18713872 15968718 19416960 19739265 16393943 10915739 16781746 17906064 14725611 16177239 11529661 19085960 12153990 19420014 2444490 15619225 19923254 12540782 12705907 14550746 19164858 19370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4518367378
MESH:C538011 Eales disease Vitamin E 4.739068938
MESH:D004487 Edema Mustard Gas 11.459260866 11428647 11428631 11402378
MESH:D004487 Edema pirinixic acid 11.4512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.4511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D016889 Endometrial Neoplasms Estradiol 2.9811473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.029294722 10568697
MESH:D004890 Erythema Mustard Gas 5.189357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Dietary Fats 13.0817967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.0815345470
MESH:D005234 Fatty Liver pirinixic acid 13.0820131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Dietary Fats 8.6718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6720067830
MESH:D005534 Foot Diseases Arsenic 5.596392382
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3316417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.1120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.1111294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.1116080930
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.3119772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.3112621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7016490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 10.1517088409
MESH:D019584 Hot Flashes Vitamin E 10.1514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0815340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.4617050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.6221332399
MESH:D006973 Hypertension Arsenic 8.729931084 11953799 16076760
MESH:D006973 Hypertension Phenylephrine 8.7212717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.7218850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.5618502941 12791704
MESH:D006987 Hypesthesia Arsenic 5.5916093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6717937319
MESH:D007248 Infertility, Male vinclozolin 6.6716467254
MESH:D007249 Inflammation Dietary Fats 8.3420412841
MESH:D007249 Inflammation Mustard Gas 8.349357497 9260866 17524151 11428631 8975870 11402378 11428620 11428647 16001271
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3412200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.2416624496
MESH:D007333 Insulin Resistance Dietary Fats 12.3011836018 18457598
MESH:D007333 Insulin Resistance Estradiol 12.3016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.3016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007642 Keratosis Arsenic 5.0112749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 10.0515629191 12587719
MESH:D007674 Kidney Diseases Estradiol 10.0515618244
MESH:D007674 Kidney Diseases Vitamin E 10.0512488133
MESH:D007680 Kidney Neoplasms Estradiol 2.9815610895
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5517339181
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7516417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8818296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.9316169303
MESH:D008107 Liver Diseases Acetaminophen 4.0712969438 19460945 19784758 12587719 16611625 11587558 19014921 16610002
MESH:D008107 Liver Diseases Arsenic 4.0711134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 10.6916368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.6921137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 10.6920007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.6916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1112151625
MESH:D008171 Lung Diseases Mustard Gas 7.5518161513 18702808
MESH:D008171 Lung Diseases Vitamin E 7.5516863852
MESH:D008175 Lung Neoplasms Arsenic 6.6017306315 17976673 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.6020464547 18816296 18569708 17053015 20135361 20869020 18520028 20064080 6695378
MESH:D008175 Lung Neoplasms Mustard Gas 6.608781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6011884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 6.6011062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5616891317 17203775 11807958 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.5119453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008569 Memory Disorders Methylmercury Compounds 4.9218436314
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D009069 Movement Disorders Methylmercury Compounds 5.3318436314
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D017202 Myocardial Ischemia Arsenic 9.0115371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.0112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.2616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.2616411023
MESH:D009369 Neoplasms Benzo(a)pyrene 4.8211141357
MESH:D009369 Neoplasms pirinixic acid 4.8217405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009421 Nervous System Malformations Estradiol 9.5016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5014600291
MESH:D009436 Neural Tube Defects Arsenic 3.4516620997
MESH:D009447 Neuroblastoma Topotecan 3.8515176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.3817056641
MESH:D009503 Neutropenia Mustard Gas 3.987688884 16761898
MESH:D009765 Obesity Dietary Fats 4.4419632207 16723640 18674790 11836018 20518802 18457598 20132043 17217161 21332399
MESH:D009765 Obesity pirinixic acid 4.4420558911
MESH:D010051 Ovarian Neoplasms Arsenic 4.9517306315
MESH:D010051 Ovarian Neoplasms Estradiol 4.9519401270
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.1916093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.016392382 16905509 15371236
MESH:D011041 Poisoning Mustard Gas 3.8015727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 16.5318436314
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.5311399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.5318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.9518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.0716140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0715084515
MESH:D011472 Prostatitis vinclozolin 4.9518629315
MESH:D011507 Proteinuria Arsenic 4.0121343184
MESH:D011537 Pruritus Ethinyl Estradiol 9.5915861022 16919318
MESH:D011537 Pruritus Mustard Gas 9.5918058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9317620002 17894541 17720292 10334151 17266442
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012852 Sinusitis Phenylephrine 4.727327846
MESH:D012871 Skin Diseases Arsenic 8.0116702368 19834688 6392382 18709164 17938729 17453740 17050553 15952646 16759981 17548696 16353154
MESH:D012871 Skin Diseases Mustard Gas 8.0116961503 15451306 12880345
MESH:D012871 Skin Diseases Vitamin E 8.0118709164
MESH:D012878 Skin Neoplasms Arsenic 9.4517029826 19538983 17050553 15504454 17976673 16251483
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.4510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.4516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Vitamin E 3.5216517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013978 Tibial Fractures Estradiol 4.7219048282
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.1717976673 11144890 17306315 19322015 19429237 18640142 15987713
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1717053015
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014652 Vascular Diseases Arsenic 4.7517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D015430 Weight Gain Dietary Fats 3.7416723640
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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