AutismKB 2.0

Annotation Detail for POLDIP2


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Basic Information Top
Gene Symbol:POLDIP2 ( DKFZp586F1524,PDIP38,POLD4 )
Gene Full Name: polymerase (DNA-directed), delta interacting protein 2
Band: 17q11.2
Quick LinksEntrez ID:26073; OMIM: 611519; Uniprot ID:PDIP2_HUMAN; ENSEMBL ID: ; HGNC ID: 23781
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of POLDIP2 mRNAdecreases expression 18648102
C006632 arsenic trioxide arsenic trioxide results in increased expression of POLDIP2 mRNAincreases expression 20458559
D001554 Benzene Benzene results in increased expression of POLDIP2 mRNAincreases expression 15878777
D016572 Cyclosporine Cyclosporine results in decreased expression of POLDIP2 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of POLDIP2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLDIP2 mRNAaffects cotreatment|increases expression 17942748
D011794 Quercetin Quercetin results in increased expression of POLDIP2 proteinincreases expression 15221776
D013629 Tamoxifen Tamoxifen results in increased expression of POLDIP2 mRNAincreases expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLDIP2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4611798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000741 Anemia, Aplastic Benzene 4.5514761424 17661222 11369114
MESH:D000743 Anemia, Hemolytic Quercetin 4.4817084956
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001260 Ataxia Telangiectasia Quercetin 5.3115336622
MESH:D001327 Autoimmune Diseases Quercetin 4.7119761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.7816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001855 Bone Marrow Diseases Benzene 5.6116183116
MESH:D001943 Breast Neoplasms Benzene 2.0111921183 17162533
MESH:D001943 Breast Neoplasms Quercetin 2.0118628248
MESH:D001943 Breast Neoplasms Tamoxifen 2.0115565566 19066611 20544844 16818667 17893378 19288272 18815881 18997820 17049068 19155303 18855134 16273361 19221464 21152245 18629630 20065188 19115204 11161223 19487384 20859285 16202921 20005174 17440819 18821012 19410462 19103187 16873071 19289846 15668708 18984771 19011961 20390343 19142967 20135344 19084267 17242785 21138602 19244106 19189212 18425577 18351453 17261762 19189210 19200415 19059307
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D002105 Cadmium Poisoning Quercetin 5.9216962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.867296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8616217749 15553829 14691202 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.8619519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8616924424
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.2617234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D006332 Cardiomegaly Quercetin 7.2019794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.2016120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.107505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1012371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.4319486331 9022650
MESH:D002779 Cholestasis Cyclosporine 14.4319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.4316105132 17333356 16919318 11677210 17681005 17110522 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915340226 12621046 8697196 15668235 16354765
MESH:D003110 Colonic Neoplasms Quercetin 2.4515741050 16640504 17191121 11134977 19440933 17148506 19056647
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6620501625
MESH:D015179 Colorectal Neoplasms Quercetin 2.6618095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9610525206
MESH:D019465 Craniofacial Abnormalities Benzene 3.9615643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9615322242 10048152 20055451
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003872 Dermatitis Benzene 5.0715902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1018759878 14531868 8156756 11298694 11906362 2524372 8970840 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.9319496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6919279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.8918289764 1440618 18692083 16192314 9022650 7440962 6482804 8291058 11289319 18648102 9653073 6679447 9328219
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.9019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1920544844 19155303 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.643581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6412903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver arsenic trioxide 20.8715073043
MESH:D005234 Fatty Liver Cyclosporine 20.8719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.8715345470
MESH:D005234 Fatty Liver Tamoxifen 20.8719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Cyclosporine 16.6412639820 12168785
MESH:D005355 Fibrosis Quercetin 16.6419474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.6420067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Quercetin 3.5419804834
MESH:D005910 Glioma Quercetin 3.1317643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006402 Hematologic Diseases Benzene 4.9116183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4215340226 18606429 8697196 16959395 16354765
MESH:D006943 Hyperglycemia Quercetin 4.2618262572 11834736
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Benzene 13.0517940673
MESH:D006973 Hypertension Cyclosporine 13.0510903974
MESH:D006973 Hypertension Quercetin 13.0518356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 13.0518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Tamoxifen 5.2619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2612200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.8816624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007627 Keloid Quercetin 5.2617086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.558314463 10903974 18776723
MESH:D007674 Kidney Diseases Quercetin 6.5516962696
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.586582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.5812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 13.5818625569
MESH:D007938 Leukemia arsenic trioxide 11.2215070760
MESH:D007938 Leukemia Benzene 11.2214694614 15935818 18335105 17119257
MESH:D007938 Leukemia Quercetin 11.2217468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0412560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.5219077051
MESH:D007951 Leukemia, Myeloid Benzene 10.5217506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.2316467208 20471514 17050201 19850784 16968895
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.2319478238
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3616331271 19642359 16966277 15622746 16112521 19075265 11161223 16823087 15336539 17107899 19225113 17712046 17217047 16891316 9834237 15213294 12018890 12712474 19035177 12679006 11468182 17649720 15748426 16330433 17869043
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D008064 Lipidoses Tamoxifen 3.3217567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.6312741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.6318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6312878042
MESH:D008113 Liver Neoplasms arsenic trioxide 11.3814682389
MESH:D008113 Liver Neoplasms Quercetin 11.3818980244
MESH:D008113 Liver Neoplasms Tamoxifen 11.3816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 20.211399818 598648 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 20.2120377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 20.2112562636
MESH:D008114 Liver Neoplasms, Experimental Quercetin 20.2119519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 20.2112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D017563 Lung Diseases, Interstitial Benzene 5.1814698565
MESH:D008175 Lung Neoplasms arsenic trioxide 6.8619825857 11798837
MESH:D008175 Lung Neoplasms Benzene 6.8612562636
MESH:D008175 Lung Neoplasms Quercetin 6.8616280456
MESH:D008175 Lung Neoplasms Tamoxifen 6.8618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.8611884234 19555203
MESH:D008223 Lymphoma Benzene 3.9017584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 11.2212562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 11.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.7311921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.7319196723 11731420 16827153 14580682 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009101 Multiple Myeloma arsenic trioxide 8.0519417148 19549372 15949261 14977855 11468182
MESH:D009101 Multiple Myeloma Benzene 8.0517119195
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616882451 16105982
MESH:D009203 Myocardial Infarction Quercetin 3.0719595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.9819207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.973581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009369 Neoplasms Quercetin 2.8915185748
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819196722 19200415 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 13.086679447
MESH:D009436 Neural Tube Defects arsenic trioxide 13.0810525206
MESH:D009436 Neural Tube Defects Benzene 13.0815643154
MESH:D020078 Neurogenic Inflammation Quercetin 4.6217929310
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.934026338 6482804
MESH:D009784 Occupational Diseases Benzene 9.9315727169 17479406 16737584 17119257 15935809 15612468 15913788 15576619 17178637
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4819495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.4019769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Benzene 8.4012562636
MESH:D010051 Ovarian Neoplasms Quercetin 8.4019005980
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6815580305
MESH:D010190 Pancreatic Neoplasms Quercetin 5.6816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.8312371664
MESH:D011230 Precancerous Conditions Quercetin 9.8319056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11399792 11222880 11896295
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5719131511
MESH:D011471 Prostatic Neoplasms Quercetin 2.5714715546 17292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.9216862918
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.7317007042
MESH:D013274 Stomach Neoplasms Benzene 2.7312562636
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013953 Thymus Neoplasms Benzene 5.2910850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.771399818 6582329 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.7719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.638074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.6312973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Quercetin 12.6316720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.638653321 16712894 17572228
MESH:D014594 Uterine Neoplasms Benzene 10.5312562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.5314692618
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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