AutismKB 2.0

Annotation Detail for HERC4


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Basic Information Top
Gene Symbol:HERC4 ( DKFZp564G092,KIAA1593 )
Gene Full Name: hect domain and RLD 4
Band: 10q21.3
Quick LinksEntrez ID:26091; OMIM: 609248; Uniprot ID:HERC4_HUMAN; ENSEMBL ID: ENSG00000148634; HGNC ID: 24521
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
No data
No data
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of HERC4 mRNAaffects expression 17562736
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of HERC4 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HERC4 mRNAdecreases expression 19150397
D001710 Biotin Biotin results in increased expression of HERC4 mRNAincreases expression 15219929
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HERC4 mRNAincreases expression 17942748
C029938 nickel sulfate nickel sulfate results in decreased expression of HERC4 mRNAdecreases expression 16780908
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HERC4 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of HERC4 mRNAdecreases expression 18445702
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury nickel sulfate 10.1719131640 12718980 11954676 16100012
MESH:D055371 Acute Lung Injury pirinixic acid 10.1718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4211677210 16105132 17333356 17681005 15861022 16919318 17110522
MESH:D002779 Cholestasis pirinixic acid 8.4219176532
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 4.0211298694 16780908 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6511529661 19085960 2444490 19739265 16485898 11287661 12392966 16081117 10774834 18071297 12540782 10915739 14550746 16109766 19164858 17906064 12958197 14986274 11739529 16227642 18713872 17522070 12594235 16177239 15619225 11834606 19370779 12705907 10663392 11421492 16393943 15968718 19923254 14725611 11743745 11461765 17562736 19416960 12153990 16781746 19420014
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5015345470
MESH:D005234 Fatty Liver pirinixic acid 8.5020131406 19236843
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3519772884 16221962 18467677 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6812587719 12969438 16610002 19784758 16611625 19014921 11587558 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9020007298 16377806 15890375
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3817365036
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2716166281 16966607 18303189
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2510923243
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1115814490 17365031 17975199 17322281
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
Pathway ID Pathway Name
KEGG:04120 Ubiquitin mediated proteolysis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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