AutismKB 2.0

Annotation Detail for SERBP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SERBP1 ( CHD3IP,DKFZp564M2423,FLJ90489,HABP4L,PAI-RBP1,PAIRBP1 )
Gene Full Name: SERPINE1 mRNA binding protein 1
Band: 1p31.3
Quick LinksEntrez ID:26135; OMIM: 607378; Uniprot ID:PAIRB_HUMAN; ENSEMBL ID: ENSG00000142864; HGNC ID: 17860
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1859Ovarian cancer
2044Pre-Eclampsia
2074Asthma
2237Neoplasm metastasis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SERBP1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SERBP1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of SERBP1 mRNAincreases expression 20458559
C006780 bisphenol A bisphenol A results in decreased expression of SERBP1 mRNAdecreases expression 20678512
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SERBP1 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of SERBP1 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SERBP1 mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SERBP1 mRNAincreases expression 17108234
D006064 Gonadotropins, Equine Chorionic Gonadotropin promotes the reaction [Gonadotropins, Equine results in increased expression of SERBP1 protein]increases expression|increases reaction 15814896
D006064 Gonadotropins, Equine Gonadotropins, Equine results in increased expression of SERBP1 proteinincreases expression 15814896
D006063 Chorionic Gonadotropin Chorionic Gonadotropin promotes the reaction [Gonadotropins, Equine results in increased expression of SERBP1 protein]increases expression|increases reaction 15814896
D011374 Progesterone Progesterone affects the activity of SERBP1 proteinaffects activity 15814896
D012643 Selenium Selenium results in decreased expression of SERBP1 mRNAdecreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of SERBP1 mRNAaffects expression 17440010
C066340 tolcapone tolcapone binds to SERBP1 proteinaffects binding 19783845
D014501 Uranium Uranium affects the expression of SERBP1 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of SERBP1 mRNAaffects expression 15672453
C025643 vinclozolin vinclozolin affects the expression of SERBP1 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of SERBP1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.2511798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2514692618
MESH:D000236 Adenoma Diethylnitrosamine 2.8210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.8619052882 17162532 17620307 16434500 18056438 19061943
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.2611080934
MESH:D000544 Alzheimer Disease tolcapone 3.2720150427
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6019015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.6316206674
MESH:D001862 Bone Resorption bisphenol A 3.8211985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3117868700
MESH:D001930 Brain Injuries Progesterone 4.2215380490 15845082 15665606
MESH:D001943 Breast Neoplasms bisphenol A 1.9617123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Progesterone 1.9615562024 16175315 17614352
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2911589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8916050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.513084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.5115073043 15553829 16217749 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.5119418558 20514400 20101231 19519916 17162532 17428255 19107877 16878318 19383236 18393292 16681979 17138121 16698587 20935162 18978308 3084413 20524982 17761372 20432363 18506893 18788625 17173139 19919837 19171122 21159647 18785209 19208518 10672840 16569478 19394651 16935385 16288022 16328049 17978847 16779866 17055752 16830150 11831363 19822196 19052882 20214788 16807293 18056438 19539802 16502159 20084675 18971187 18210153 19335982 19701751 18691550 3581430 10737359 16540662 20727157 18665156 20007298 20512989 18494052
MESH:D002278 Carcinoma in Situ bisphenol A 4.9517123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0812490120
MESH:D002386 Cataract Acetaminophen 2.5510977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.5021159647 7505956 2727394 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.6519052882
MESH:D002779 Cholestasis Cyclosporine 7.6619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6617110522 16105132 15861022 16919318 17333356 11677210 17681005
MESH:D003092 Colitis Selenium 3.7417936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7010525206
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7019769572
MESH:D003456 Cryptorchidism vinclozolin 4.3014966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0515213294
MESH:D003866 Depressive Disorder tolcapone 4.277768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 4.8610440460
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1820387270
MESH:D003929 Diabetic Neuropathies Progesterone 4.4517187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9319420014 10663392 16393943 18071297 15619225 11461765 19370779 17906064 12594235 19416960 11743745 17522070 10774834 14725611 17562736 11421492 16485898 16781746 11739529 12705907 2444490 19085960 18713872 10915739 19923254 12958197 15968718 14986274 12392966 16081117 19164858 11287661 14550746 12153990 11834606 12540782 16177239 16227642 11529661 19739265 16109766
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.9319107877
MESH:D056486 Drug-Induced Liver Injury Selenium 8.9315131321
MESH:D056486 Drug-Induced Liver Injury tolcapone 8.9316604736 19783845
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.3711455177
MESH:C538011 Eales disease Vitamin E 4.689068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.9017692515
MESH:D004715 Endometriosis Progesterone 3.7316134523
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0916302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3012903497
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.9219578428
MESH:D005234 Fatty Liver arsenic trioxide 18.4315073043
MESH:D005234 Fatty Liver Cyclosporine 18.4319224547
MESH:D005234 Fatty Liver Diethylnitrosamine 18.4321071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.4315345470
MESH:D005355 Fibrosis Cyclosporine 3.1012168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2216904648
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D006330 Heart Defects, Congenital Vitamin E 2.9616080930
MESH:D006333 Heart Failure Selenium 3.0517162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6916863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.7217440010
MESH:D019584 Hot Flashes Vitamin E 3.9414716179
MESH:D006930 Hyperalgesia Acetaminophen 2.6616870215
MESH:D006973 Hypertension Cyclosporine 2.0810903974
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5617937319
MESH:D007248 Infertility, Male vinclozolin 6.5616467254
MESH:D007249 Inflammation Diethylnitrosamine 5.0918785209
MESH:D007249 Inflammation Progesterone 5.0915869954
MESH:D007251 Influenza, Human Selenium 10.8616624496
MESH:D007251 Influenza, Human Vitamin E 10.8616624496
MESH:D007333 Insulin Resistance bisphenol A 3.2616393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Acetaminophen 9.8612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.868314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 9.8612488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8416518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7012371664
MESH:D007938 Leukemia arsenic trioxide 2.8115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7517077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7219077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1316467208 16968895 20471514 17050201 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1816112521 15622746 19075265 12018890 11468182 15748426 19225113 17712046 16891316 19642359 17649720 17217047 17107899 12712474 11161223 16330433 15213294 16331271 16966277 17869043 19035177 12679006 16823087 15336539 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3116882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7016417039
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8018407596 18522880 19638242 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.8916169303
MESH:D008107 Liver Diseases Acetaminophen 3.8719460945 16611625 11587558 12587719 12969438 16610002 19784758 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2017185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 7.4414682389
MESH:D008113 Liver Neoplasms Clofibric Acid 7.4417602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.4420492335 2862719 10737359 18648771 18754104 15885732 19638242 20501860 20137499 19996281 19690152 18977376 12771043 21167192 20405173 20118626 18644402 19294768 20452335 15175105 12112319 18978307 9163691 19254457 21278145 21071580 19426721 19073162 19256749 2422723 19812893 19833225 19499222 19642983 20583210 20101389 19255062 19090486 19850985 16942905 21047994 20434301 19427195 19551842
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.9020377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.903124819 18544905 16842330 16267830 18282651 18775883 19004024 18079962 18308698 17942915 19519916 19539802 18093689 19126423 17174075 21159647 18164116 18253720 9362446 17854601 2563599 19009564
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3115213294
MESH:D008171 Lung Diseases Vitamin E 3.1516863852
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4519825857 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4520970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Vitamin E 3.4511062179
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.0411408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.0415318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008654 Mesothelioma Selenium 2.7715107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0711468182 19417148 15949261 14977855 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1216105982 16882451
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9216624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.559029167 3581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2419348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 3.9316427766 11399458
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0910525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.0618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.0620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0920387270
MESH:D010049 Ovarian Diseases bisphenol A 4.9511985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.8912452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Progesterone 4.8917393432 16525653
MESH:D010146 Pain Acetaminophen 2.3516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.2215580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.2216540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1219927285
MESH:D010300 Parkinson Disease tolcapone 3.589305320 8739811 1977408 10651109 16758261 19578428 20216409 7566641 8635184 19783845 20334432 11432539 18328768 9754991 9591521 9333106 17089403 11793426 11746615 11586115 9708959
MESH:D010954 Plasmacytoma Selenium 4.8615087411
MESH:D011230 Precancerous Conditions Cyclosporine 8.8212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.822563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.6510548101
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.6518220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.9018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.1720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6219131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6216740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6215084515
MESH:D011472 Prostatitis vinclozolin 4.9018629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.2816919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011629 Puberty, Precocious bisphenol A 4.7510548101
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8418045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9216646077
MESH:D012871 Skin Diseases Vitamin E 2.4318709164
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.2415862959 16503802
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4317007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4318456281
MESH:D020521 Stroke Vitamin E 3.4816517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.9516684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.0819014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.087505956
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9315213294
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.9219578428
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.4620435036 11780464 12845720 12973940
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D014591 Uterine Diseases bisphenol A 4.9814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D014820 Vitiligo tolcapone 5.1510573327
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved