AutismKB 2.0

Annotation Detail for RSL1D1


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Basic Information Top
Gene Symbol:RSL1D1 ( CSIG,DKFZP564M182,MGC138433,MGC142259,PBK1 )
Gene Full Name: ribosomal L1 domain containing 1
Band: 16p13.13
Quick LinksEntrez ID:26156; OMIM: NA; Uniprot ID:RL1D1_HUMAN; ENSEMBL ID: ENSG00000171490; HGNC ID: 24534
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RSL1D1 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of RSL1D1 mRNAdecreases expression 15761015
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RSL1D1 mRNAincreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RSL1D1 mRNAdecreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RSL1D1 mRNAincreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of RSL1D1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RSL1D1 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen affects the expression of RSL1D1 mRNAaffects expression 17555576
C004648 testosterone enanthate testosterone enanthate affects the expression of RSL1D1 mRNAaffects expression 17440010
D014635 Valproic Acid Valproic Acid results in decreased expression of RSL1D1 mRNAdecreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.778875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma arsenic trioxide 7.2911798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2920127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2914692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8616609825 18396377 18985861 18940202 18316065 19460635 15238991 19232924 18775368 17157402 20603192 17688650 18558336 17507914 18177632
MESH:D001714 Bipolar Disorder Valproic Acid 3.1720046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8816206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.528888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0620146248 17474063
MESH:D001943 Breast Neoplasms Tamoxifen 2.0618984771 20135344 19066611 19011961 18855134 19189210 20390343 19221464 19142967 19084267 16202921 20859285 19103187 17893378 19059307 19200415 11161223 18629630 17242785 21152245 19288272 18815881 19289846 17440819 21138602 19155303 17261762 19115204 16273361 15668708 19410462 15565566 20065188 19189212 18351453 20544844 18821012 18997820 17049068 20005174 19487384 19244106 16818667 16873071 18425577
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.703084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7015553829 11135700 15073043 16217749 14691202
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7016924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0112371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D002779 Cholestasis Cyclosporine 8.2819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2817333356 16105132 17110522 17681005 15861022 16919318 11677210
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7510525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.758888407 17688650 16575769
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9616177239 17522070 19420014 11834606 12392966 11461765 12540782 16781746 16081117 10915739 11529661 17906064 19370779 11421492 2444490 14725611 17562736 18071297 19923254 12705907 15619225 19739265 16393943 11287661 16109766 14986274 15968718 19416960 14550746 18713872 11743745 10663392 19164858 16227642 12958197 12153990 11739529 10774834 12594235 19085960 16485898
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.961733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1720544844 16202921 19155303 17893378
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.233922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0320417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.777562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4820426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.4812903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4816530937
MESH:D005234 Fatty Liver arsenic trioxide 27.0115073043
MESH:D005234 Fatty Liver Cyclosporine 27.0119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.0115345470
MESH:D005234 Fatty Liver Tamoxifen 27.0114986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 27.0114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.378888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Cyclosporine 3.4012639820 12168785
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0617440010
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tamoxifen 2.4519457130
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.1618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.8818625569
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0117050201 20471514 19850784 16467208 16968895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0116294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3419075265 11161223 16823087 15748426 19642359 12018890 17649720 12679006 19035177 16966277 15213294 16330433 16891316 9834237 16112521 15336539 11468182 16331271 17107899 12712474 19225113 17869043 15622746 17217047 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7418564211
MESH:D008107 Liver Diseases Acetaminophen 1.6711587558 19460945 16611625 16610002 12587719 19014921 12969438 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 7.8514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8521137059 20195826
MESH:D008113 Liver Neoplasms Tamoxifen 7.8516684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8520377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5311798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5317053015 20869020 20464547 18569708 18520028 20064080 18816296 20135361 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 3.5318625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7411731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3318803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2514977855 11468182 19417148 19549372 15949261
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.7816882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.7817596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2511141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219200415 19189210 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D009436 Neural Tube Defects arsenic trioxide 7.7510525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.758888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4619769630 12452020 16624393
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1120603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4919131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4917292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.8611422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8714763951 11044598 16876388 3137016 1511512 15475178 11738929 17978042
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4117007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4120155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.7112973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7117053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.7116712894 17572228 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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