AutismKB 2.0

Annotation Detail for GARS


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GARS ( CMT2D,DSMAV,GlyRS,HMN5,SMAD1 )
Gene Full Name: glycyl-tRNA synthetase
Band: 7p14.3
Quick LinksEntrez ID:2617; OMIM: 600287; Uniprot ID:SYG_HUMAN; ENSEMBL ID: ENSG00000106105; HGNC ID: 4162
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
TRNA-CHARGING-PWYtRNA charging pathway
Pathway IDPathway Name
hsa00970Aminoacyl-tRNA biosynthesis
Pathway IDPathway Name
Gene Expression
No data
No data
Pathway IDPathway Name
500660Cytosolic tRNA aminoacylation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1726Charcot-Marie-Tooth disease
No data
No data
Desease Name
Neuropathy, distal hereditary motor, type V
Charcot-Marie-Tooth disease, type 2D
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GARS mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GARS mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of GARS mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GARS proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in increased expression of GARS mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GARS mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GARS mRNAdecreases expression 20018196
C095105 bexarotene bexarotene results in decreased expression of GARS mRNAdecreases expression 17178900
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of GARS mRNAdecreases expression 15003993
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GARS mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of GARS mRNAincreases expression 20106945
D002945 Cisplatin GARS protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of GARS mRNAaffects cotreatment|increases expression 15784690
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GARS mRNAaffects cotreatment|affects expression 17602206
D004958 Estradiol Estradiol results in increased expression of GARS mRNAincreases expression 20106945
D015525 Fatty Acids, Omega-3 Fatty Acids, Omega-3 results in decreased expression of GARS mRNAdecreases expression 16823509
C056933 fumonisin B1 fumonisin B1 results in increased expression of GARS mRNAincreases expression 16221962
C419708 gefitinib gefitinib results in increased expression of GARS mRNAincreases expression 16685379
D043371 Fatty Acids, Omega-6 Fatty Acids, Omega-6 results in decreased expression of GARS mRNAdecreases expression 16823509
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GARS mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of GARS mRNAincreases expression 19482888
D011374 Progesterone Progesterone results in increased expression of GARS mRNAincreases expression 18037150
D018038 Sodium Selenite Sodium Selenite results in increased expression of GARS mRNAincreases expression 18175754
C025462 sulindac sulfide sulindac sulfide results in increased expression of GARS mRNAincreases expression 12734198
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GARS mRNAdecreases expression 20106945
D014212 Tretinoin Tretinoin results in decreased expression of GARS mRNAdecreases expression 16140955
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of GARS mRNAaffects cotreatment|increases expression 15784690
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 13.047525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.046195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.0415322242 11752688 14514962
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.629612607
MESH:D058186 Acute Kidney Injury Cisplatin 3.7715814532 17670903 12690470
MESH:D000230 Adenocarcinoma arsenic trioxide 9.7411798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.7420127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 9.7417638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 9.7411473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.236695378
MESH:D000236 Adenoma Diethylnitrosamine 6.236695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.1217162532 19061943 16434500 19052882 17620307 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.1217620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.1216835633
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D000544 Alzheimer Disease sulindac sulfide 3.0418759972
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D001169 Arthritis, Experimental Tretinoin 2.9516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-3 8.8018448859
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-6 8.8018448859
MESH:D001321 Autistic Disorder Fatty Acids, Omega-3 3.5016920077
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.2416206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.2412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.2416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6714601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1317868700
MESH:D001930 Brain Injuries Progesterone 4.0515665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.5617474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 4.5616344269 16818667
MESH:D001943 Breast Neoplasms Cisplatin 4.5619526202 18382427
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.5617474063
MESH:D001943 Breast Neoplasms Estradiol 4.5612948864 16675129 17289903 17261762 19861407 14630087 18497071 17018787
MESH:D001943 Breast Neoplasms Progesterone 4.5617614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5620435547
MESH:D001943 Breast Neoplasms Tretinoin 4.5616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1311589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 19.2316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 19.2316705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 19.2321507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 19.2311135700 14691202 15553829 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 19.2317982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.2316698587 10672840 19418558 17173139 20101231 16569478 17162532 18393292 16540662 17978847 19383236 20727157 19107877 18210153 20524982 19701751 20432363 16502159 18494052 19052882 21159647 16288022 16681979 19919837 18691550 19208518 18056438 16935385 16830150 17138121 16779866 19171122 19822196 20214788 18971187 16878318 3581430 16328049 10737359 17055752 19335982 20514400 18665156 18978308 20007298 19539802 20512989 17761372 3084413 18506893 17428255 18788625 19394651 16807293 20084675 11831363 18785209 19519916 20935162
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.2316924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 19.2320935162 20007298 6705139 1701930 17173139
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 19.231917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 12.2716247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 12.2712023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 12.2716230376 15496427 19233551 20005069 18347146 17290066
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 12.2712391285
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6619014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9312490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.2020419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.2017066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.2016051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2518850075 18670907 16120746
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.2114694615
MESH:D002386 Cataract Tretinoin 7.2117460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 19.566135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 19.5620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.5612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.562727394 21159647 17174075 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.5618566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.044080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:C537993 Charcot-Marie-Tooth disease, Type 2D marker/mechanism
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002779 Cholestasis Cyclosporine 2.7619486331
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.5415894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4715668235 8697196 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.479407595
MESH:D003092 Colitis Tretinoin 3.5017035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.5620501625
MESH:D015179 Colorectal Neoplasms Cisplatin 3.5615273666
MESH:D015179 Colorectal Neoplasms gefitinib 3.5617594712
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.6015095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.6017141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6310048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.639125849 16925845 9664655 17551590 14991402 10589399 9142499 9211117 8800419 9224671
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.2018551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.2018551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9015213294
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6016285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2817187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 17.7121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.7121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 17.7121346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.7119107877
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 17.7116221962
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 17.7115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.7120420201
MESH:D004362 Drug Toxicity Cisplatin 18.4112649298 12231392 19839026 15033597
MESH:D004362 Drug Toxicity Lamivudine 18.4115040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 18.4111462148
MESH:D004362 Drug Toxicity Zidovudine 18.4115040536
MESH:D004421 Dystonia Phenobarbital 3.811851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2316714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.5817692515
MESH:D016889 Endometrial Neoplasms Estradiol 6.9611473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.9616569247
MESH:D004715 Endometriosis Progesterone 8.3216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.329294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.903659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.663922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.376401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.047750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.813659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.9520426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 9.9512903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.9516530937
MESH:D004938 Esophageal Neoplasms Cisplatin 9.9517638652 15464296 16481741 15173087 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.3216938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 17.2615073043
MESH:D005234 Fatty Liver Cyclosporine 17.2619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 17.2621071580 20387270
MESH:D005234 Fatty Liver Zidovudine 17.2618299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005355 Fibrosis Cyclosporine 13.5212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5220067830
MESH:D005355 Fibrosis Tretinoin 13.5217994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0616904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005909 Glioblastoma Tretinoin 2.8717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.4515464296 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.4516096774
MESH:D034381 Hearing Loss Cisplatin 4.1219898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2515464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.4620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.4610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.4614991402 9664655
MESH:D006402 Hematologic Diseases Zidovudine 4.5212579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006509 Hepatitis B Lamivudine 4.9117703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.9112044531 16476009 15274664 15631357 15309715
MESH:D006529 Hepatomegaly fumonisin B1 13.3516221962
MESH:D006529 Hepatomegaly Phenobarbital 13.3516109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.3516120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D015658 HIV Infections Lamivudine 6.7020032539 11141242 17530837 9296927
MESH:D015658 HIV Infections Zidovudine 6.7011698656 11141242 20032539 17358032 11363243
MESH:D006689 Hodgkin Disease Cisplatin 3.4216200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8315340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.0516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006973 Hypertension Cyclosporine 4.6810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6818670907 18850075
MESH:D006976 Hypertension, Pulmonary gefitinib 4.5518424623
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 6.0218424623
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1915869954
MESH:D007249 Inflammation Diethylnitrosamine 11.1318785209
MESH:D007249 Inflammation Fatty Acids, Omega-3 11.1317296493
MESH:D007249 Inflammation Progesterone 11.1315869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.1312878042 12200463
MESH:D007333 Insulin Resistance Estradiol 6.9816627594 16393666
MESH:D007333 Insulin Resistance Sodium Selenite 6.9814714311
MESH:D007410 Intestinal Diseases Tretinoin 3.5617994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.9315464296
MESH:D007674 Kidney Diseases Cisplatin 9.4215190930 12649298 12231392 19839026 18289764
MESH:D007674 Kidney Diseases Cyclosporine 9.4218776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.4215618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 26.9016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 26.9016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 26.9012371664
MESH:D007680 Kidney Neoplasms Estradiol 26.9015610895
MESH:D007680 Kidney Neoplasms gefitinib 26.9018625569
MESH:D007680 Kidney Neoplasms Zidovudine 26.9012579204
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5811231351
MESH:D007938 Leukemia arsenic trioxide 6.0015070760
MESH:D007938 Leukemia Tretinoin 6.0017143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.2112560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 9.2120370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.8419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.8416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7516467208 16968895 17050201 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7519850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.1816112521 17649720 19075265 15748426 11468182 19225113 16823087 12018890 17107899 17217047 19035177 11161223 9834237 15213294 12712474 16891316 16331271 17869043 17712046 15336539 19642359 16966277 15622746 16330433 12679006
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.1817217047 19029980 16140955 15748426 19642359 16766008 17339181 12679006 17107899 16331271 17712046 17368321 16891316 16788101 17649720 17506722 19035177 19225113 17294898 16935935 16823087 19075265 17361223 17301526 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1516882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.169224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.2618522880 19638242 18665156 18407596 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 6.2621047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.3016248980 18397230
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9217034775
MESH:D008107 Liver Diseases Phenobarbital 3.9219363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 24.577678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.579163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 24.5714682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.5720195826 21137059
MESH:D008113 Liver Neoplasms Clofibric Acid 24.5717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.572862719 20501860 21278145 20583210 19690152 20118626 20101389 18978307 20137499 19427195 21071580 19255062 21167192 15885732 18648771 19833225 12771043 19073162 12112319 2422723 19638242 19996281 19254457 19090486 18754104 19850985 15175105 16942905 19294768 21047994 19499222 20434301 20452335 19551842 19812893 20405173 18977376 18644402 19426721 9163691 19642983 20492335 19256749 10737359
MESH:D008113 Liver Neoplasms Phenobarbital 24.5719812893 15975961 8742319 21047994 19482888 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.5716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 21.682876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 21.688603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 21.6820377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.683124819 9362446 16842330 16267830 18093689 18079962 19126423 19009564 17174075 18308698 21159647 19539802 18164116 18544905 18253720 18775883 19519916 17942915 18282651 17854601 2563599 19004024
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 21.6817172636 1399818 6150874 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.6812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1915213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 12.5314755239
MESH:D008175 Lung Neoplasms arsenic trioxide 12.5319825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.5320464547 17053015 18569708 20135361 18816296 18520028 20869020 6695378 20064080
MESH:D008175 Lung Neoplasms bexarotene 12.5317849452
MESH:D008175 Lung Neoplasms Cisplatin 12.5311798837 6189445 17225452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.536695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.5311884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 12.5318800350
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.8614737004
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9411161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 13.2815591091 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.2817203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 13.2818375820
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.2811408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.2719453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Cisplatin 3.3812374674 16809738 18176117 16248763 11135225 17761969 12393984 15577323 12883367 16432458 17023156 18505091 18332650
MESH:D008545 Melanoma Tretinoin 3.3816752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.5615990972
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D008654 Mesothelioma Cisplatin 3.1617638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.6317358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0316381670
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9615949261 14977855 19417148 19549372 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.0016105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0017596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1216810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.6418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.647678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7616624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.483581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 7.7211141357
MESH:D009369 Neoplasms Cisplatin 7.7216773208
MESH:D009369 Neoplasms Tretinoin 7.7216946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.5719196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2815464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 15.1611399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.1614600291
MESH:D009421 Nervous System Malformations Tretinoin 15.169125849
MESH:D009436 Neural Tube Defects arsenic trioxide 6.8510525206
MESH:D009436 Neural Tube Defects Tretinoin 6.859142499
MESH:D009447 Neuroblastoma Cisplatin 3.348761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1720387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.498761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
OMIM:600794 NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE V marker/mechanism
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.1016049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.1016049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 14.1014694615
MESH:D010018 Osteomalacia Phenobarbital 4.1517016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 14.2716624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Cisplatin 14.2717225452 19769630 6897625 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 14.2719401270
MESH:D010051 Ovarian Neoplasms Progesterone 14.2716525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 14.2716936753
MESH:D010146 Pain Tretinoin 2.7416870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 15.5115580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 15.5119003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.5116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 15.5116965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.5115976015
MESH:D010235 Paraganglioma arsenic trioxide 3.9719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.1115464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.1317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.2512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.252563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.252563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811118676 11896295 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8919131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms gefitinib 1.8915651060 17914592 16685379
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8918760546
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.2812752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D011658 Pulmonary Fibrosis gefitinib 3.9318424623
MESH:D051437 Renal Insufficiency Cisplatin 4.2015464296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.329296927
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9016283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.6716646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.6714601052
MESH:D012640 Seizures 2,4-dinitrotoluene 8.9918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.9918551238
MESH:D012640 Seizures Phenobarbital 8.9911442880 16876388 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.616407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.7319755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.738532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.7316192470
MESH:D012878 Skin Neoplasms Tretinoin 12.7316467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1315464296
MESH:D013119 Spinal Cord Injuries Progesterone 4.0716503802 15862959
MESH:D013274 Stomach Neoplasms arsenic trioxide 8.0217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 8.0220155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 8.0215958060 17522103 18396642
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 8.0218456281
MESH:D013274 Stomach Neoplasms Tretinoin 8.0217261132
MESH:D013274 Stomach Neoplasms Zidovudine 8.0217696246
MESH:D013736 Testicular Neoplasms Cisplatin 4.4315464296 17225452
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 20.8119014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 20.817505956
MESH:D013964 Thyroid Neoplasms gefitinib 20.8116940797
MESH:D013964 Thyroid Neoplasms Phenobarbital 20.811399818
MESH:D013964 Thyroid Neoplasms Tretinoin 20.8116026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6016051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7515213294
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.9216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.9216049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 14.9212973940 12845720 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.9217053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 14.9217225452 15464296 12973940
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.2810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.2810091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 8.9616803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.9616129372
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.4518645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.4016752155
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D014625 Vaginal Neoplasms Cisplatin 10.5115577323
MESH:D014625 Vaginal Neoplasms Zidovudine 10.5112579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D014839 Vomiting Cisplatin 4.5111897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
KEGG:00970 Aminoacyl-tRNA biosynthesis
REACT:71 Gene Expression
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28575
    • No data
    No data
    Releated drug ID Related drug Name
    PA451125l-proline
    PA449789glycine
    PA448055l-alanine
    PA448478l-arginine
    PA449173l-cysteine
    PA10090l-glutamine
    PA449882l-histidine
    PA450197l-leucine
    PA450280l-lysine
    PA450423l-methionine
    PA450931l-phenylalanine
    PA451330l-serine
    PA451673l-threonine
    PA10323l-tryptophan
    PA451822l-tyrosine
    PA451843l-valine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00145 - Glycine Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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