AutismKB 2.0

Annotation Detail for STEAP2


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Basic Information Top
Gene Symbol:STEAP2 ( IPCA1,PCANAP1,PUMPCn,STAMP1,STMP )
Gene Full Name: six transmembrane epithelial antigen of the prostate 2
Band: 7q21.13
Quick LinksEntrez ID:261729; OMIM: 605094; Uniprot ID:STEA2_HUMAN; ENSEMBL ID: ENSG00000157214; HGNC ID: 17885
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of STEAP2 proteinaffects expression 20106945
D003010 Clorgyline Clorgyline results in increased expression of STEAP2 mRNAincreases expression 19691856
D003300 Copper STEAP2 protein results in increased reduction of Copperincreases reduction 16609065
D003300 Copper STEAP2 protein results in increased uptake of Copperincreases uptake 16609065
D016572 Cyclosporine Cyclosporine results in increased expression of STEAP2 mRNAincreases expression 20106945
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in decreased expression of STEAP2 mRNAaffects cotreatment|decreases expression 17183730
D007501 Iron STEAP2 protein results in increased reduction of Ironincreases reduction 16609065
D007501 Iron STEAP2 protein results in increased uptake of Ironincreases uptake 16609065
D015741 Metribolone Metribolone results in increased expression of STEAP2 mRNAincreases expression 17010196
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of STEAP2 mRNAaffects binding|decreases expression|increases activity 19710929
D014415 Tunicamycin Tunicamycin results in increased expression of STEAP2 mRNAincreases expression 17127020
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in decreased expression of STEAP2 mRNAaffects cotreatment|decreases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.8916640825
MESH:D000544 Alzheimer Disease Copper 4.9516410023 16962711 16866297 16325427 16886094 17119284
MESH:D000544 Alzheimer Disease Iron 4.9516640825 16563566
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.4010694572
MESH:D000740 Anemia Iron 4.5316434484 16566752
MESH:D018798 Anemia, Iron-Deficiency Copper 11.0216614410
MESH:D018798 Anemia, Iron-Deficiency Iron 11.0217162259 17147795 17375513 16569441 17163184
MESH:D000756 Anemia, Sideroblastic Iron 4.9816910769
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001145 Arrhythmias, Cardiac Iron 4.5316604332
MESH:D001260 Ataxia Telangiectasia Iron 5.6915336622
MESH:D050197 Atherosclerosis Iron 3.8016640825 16632123
MESH:D001321 Autistic Disorder Iron 2.3617352947
MESH:D001321 Autistic Disorder Valproic Acid 2.3619460635 18316065 15238991 17157402 20603192 17507914 18177632 17688650 18985861 18940202 16609825 18396377 18558336 19232924 18775368
MESH:D001424 Bacterial Infections Iron 5.4316640825
MESH:D001714 Bipolar Disorder Valproic Acid 3.1517594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D001932 Brain Neoplasms Copper 4.7117079463
MESH:D001943 Breast Neoplasms Copper 3.3417079463 15986119
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 1.9721507988 12907637 12619106
MESH:D006332 Cardiomegaly Copper 4.1117327471
MESH:D009202 Cardiomyopathies Iron 4.1516640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.5116604332
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D003110 Colonic Neoplasms Iron 2.9116640825
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003920 Diabetes Mellitus Iron 4.6016640825 16604332
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.4016506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 3.1216506275
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.211733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.3717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.183922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D005234 Fatty Liver Cyclosporine 20.2919224547
MESH:D005234 Fatty Liver Iron 20.2916640825
MESH:D005234 Fatty Liver pirinixic acid 20.2920131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 20.2919224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005355 Fibrosis Cyclosporine 3.3612168785 12639820
MESH:D005621 Friedreich Ataxia Iron 5.6416604332 16640825
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006432 Hemochromatosis Iron 4.6117053826 16640825 17255318 16604332 17236123 16574947
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006486 Hemosiderosis Iron 5.4816604332
MESH:D006521 Hepatitis, Chronic Copper 5.5417338147
MESH:D006525 Hepatitis, Viral, Human Iron 5.7316640825
MESH:D006527 Hepatolenticular Degeneration Copper 12.2017182432 17109627 16607473 17276780 19888908
MESH:D006527 Hepatolenticular Degeneration Iron 12.2017182432
MESH:D006529 Hepatomegaly Iron 9.5116890145
MESH:D006529 Hepatomegaly pirinixic acid 9.5118467677 16221962 19772884 19176532
MESH:D015658 HIV Infections Iron 3.7516597321
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007006 Hypogonadism Iron 4.5216640825
MESH:D007037 Hypothyroidism Iron 5.3016640825
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D019189 Iron Metabolism Disorders Iron 5.2217163184
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4310903974 18776723 8314463
MESH:D007676 Kidney Failure, Chronic Copper 5.0716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D007859 Learning Disorders Copper 5.0117134702
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D020961 Lewy Body Disease Iron 5.6416563566
MESH:D008103 Liver Cirrhosis Iron 3.8116640825
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008108 Liver Diseases, Alcoholic Iron 5.2216737972 17207112
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.299163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Copper 11.2920302851
MESH:D008113 Liver Neoplasms Iron 11.2916640825 20302851
MESH:D008113 Liver Neoplasms pirinixic acid 11.2920007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.848603461
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.8614755239
MESH:D008175 Lung Neoplasms Iron 2.8616640825
MESH:D008268 Macular Degeneration Iron 4.0616640825
MESH:D007706 Menkes Kinky Hair Syndrome Copper 6.1217109627 17268249
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.9417086897
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009181 Mycoses Iron 5.7316640825
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Iron 4.5816604332
MESH:D015428 Myocardial Reperfusion Injury Iron 9.0516604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.0516411023
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009389 Neovascularization, Pathologic Copper 5.1817308104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 10.0019348381 18481113
MESH:D009404 Nephrotic Syndrome Iron 10.0017178036
MESH:D009436 Neural Tube Defects Valproic Acid 3.2316359493 8888407
MESH:D019636 Neurodegenerative Diseases Iron 4.3916604332 17296847
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010003 Osteoarthritis Iron 4.0616640825
MESH:D010024 Osteoporosis Iron 3.9616648989 16640825
MESH:D010212 Papilloma Iron 4.7012065085
MESH:D020447 Parasomnias Iron 6.2817352947
MESH:D010300 Parkinson Disease Iron 3.3716640825 16563566
MESH:D010900 Pituitary Diseases Iron 5.9416604332
MESH:D011041 Poisoning Iron 4.4716604332
MESH:D017119 Porphyria Cutanea Tarda Iron 5.1816640825
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011225 Pre-Eclampsia Iron 4.5516640825
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0720603192
MESH:D011471 Prostatic Neoplasms Clorgyline 4.0019691856
MESH:D011471 Prostatic Neoplasms Copper 4.0017308104 17079463
MESH:D011528 Protozoan Infections Iron 6.2816640825
MESH:D019310 Pseudolymphoma Valproic Acid 4.8111422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012148 Restless Legs Syndrome Iron 4.6716930377
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012559 Schizophrenia Copper 4.0316842975
MESH:D012559 Schizophrenia Valproic Acid 4.0319110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8514763951 3137016 16876388 1511512 11044598 17978042 11738929 15475178
MESH:D012878 Skin Neoplasms Iron 3.5412065085
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013398 Sudden Infant Death Iron 5.6916640825
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D014376 Tuberculosis Iron 4.1916597321
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:04978 Mineral absorption
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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