AutismKB 2.0

Annotation Detail for GAS2


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Basic Information Top
Gene Symbol:GAS2 ( MGC32610 )
Gene Full Name: growth arrest-specific 2
Band: 11p14.3
Quick LinksEntrez ID:2620; OMIM: 602835; Uniprot ID:GAS2_HUMAN; ENSEMBL ID: ENSG00000148935; HGNC ID: 4167
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Apoptosis
Pathway IDPathway Name
200148Caspase cascade in apoptosis
No data
Pathway IDPathway Name
500271Caspase-mediated cleavage of cytoskeletal proteins
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GAS2 mRNAincreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of GAS2 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of GAS2 mRNAincreases expression 11264010
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GAS2 proteinaffects expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of GAS2 mRNAincreases expression 14729362
D003042 Cocaine Cocaine affects the expression of GAS2 mRNAaffects expression 15681117
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of GAS2 proteinincreases expression 17475930
D016572 Cyclosporine Cyclosporine results in decreased expression of GAS2 mRNAdecreases expression 20106945
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GAS2 mRNAaffects cotreatment|decreases expression 16054899
D004041 Dietary Fats Dietary Fats results in increased expression of GAS2 mRNAincreases expression 18042831
D004642 Emodin Emodin results in increased expression of GAS2 mRNAincreases expression 16045814
D004958 Estradiol Estradiol results in decreased expression of GAS2 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GAS2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GAS2 mRNAaffects cotreatment|increases expression 17942748
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GAS2 mRNAaffects cotreatment|decreases expression 16054899
C002950 methylformamide methylformamide analog results in decreased expression of GAS2 mRNAdecreases expression 17040096
C002950 methylformamide methylformamide results in decreased expression of GAS2 mRNAdecreases expression 17040096
C041786 palm oil palm oil results in increased expression of GAS2 mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of GAS2 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of GAS2 mRNAdecreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GAS2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of GAS2 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of GAS2 mRNAincreases expression 16221962
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GAS2 mRNAaffects cotreatment|decreases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GAS2 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of GAS2 mRNAaffects binding|decreases expression 16214954
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GAS2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GAS2 mRNAincreases expression 19933214
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of GAS2 mRNAdecreases expression 17951470
D014415 Tunicamycin Tunicamycin results in increased expression of GAS2 mRNAincreases expression 17127020
D014635 Valproic Acid Valproic Acid results in increased expression of GAS2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.446195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.4415322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.448875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8119490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma Estradiol 4.1111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1114692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.5317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.5316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.5316835633
MESH:D000544 Alzheimer Disease rosiglitazone 2.8219621015
MESH:D000550 Amblyopia Valproic Acid 5.1017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000799 Angioedema Acetaminophen 3.7110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.4717497229
MESH:D001161 Arteriosclerosis Cyclophosphamide 16.3115014928
MESH:D001161 Arteriosclerosis Dietary Fats 16.3115238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 16.3111256880
MESH:D001169 Arthritis, Experimental Dexamethasone 7.1117659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518985861 18177632 18316065 17157402 17507914 18775368 18558336 18940202 20603192 19460635 15238991 19232924 17688650 18396377 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 3.0120046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7415746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.748888407
MESH:D001943 Breast Neoplasms Cyclophosphamide 1.9517388661 18323546 11325840 15136595 18234424 17020986 12006526 16978400 15093573
MESH:D001943 Breast Neoplasms Dietary Fats 1.9520435547
MESH:D001943 Breast Neoplasms Estradiol 1.9517261762 17289903 16675129 12948864 14630087 18497071 19861407 17018787
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D003528 Carcinoma, Adenoid Cystic marker/mechanism 16762588
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.653084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.6521507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 8.6519701751
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.6516924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.6520007298 1701930 20935162 17173139 6705139
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.7616152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.4816201981
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3018850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.5110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.2712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.2718566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.124080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002779 Cholestasis Cyclosporine 12.7819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.7816919318 17333356 17681005 11677210 16105132 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 12.7819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0515668235 8697196 12621046 16354765 15340226
MESH:D019970 Cocaine-Related Disorders Cocaine 5.5819606084
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4715824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9517141729 14669216
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.7417728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7415322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.748888407 16575769 17688650
MESH:D003556 Cystitis Cyclophosphamide 4.8618372110 10498854 18093676 15276878 15643279 16614059 12913760 12388444 16413132 16651033 18433785 17979934 18483878 17010015 10700343 16989017 18295254 11948286 18710439 12161096
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.2812438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.1917446233
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.9611751995 10990075 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1818772604
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.3912642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3019279558
MESH:D003967 Diarrhea Dexamethasone 3.577237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.9117906064 11529661 16781746 12392966 11421492 16109766 17522070 14550746 14725611 11743745 15968718 18713872 19085960 19923254 12705907 17562736 16177239 11739529 10915739 12594235 14986274 10663392 18071297 19164858 16081117 19370779 11287661 19420014 16227642 16485898 12958197 2444490 11834606 15619225 19739265 10774834 12540782 16393943 12153990 19416960 11461765
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.911733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3618367378
MESH:D004421 Dystonia Phenobarbital 10.021851702
MESH:D004421 Dystonia Valproic Acid 10.021851702
MESH:D004485 Eczema Dexamethasone 4.3312438553
MESH:D004487 Edema Dexamethasone 15.4819703484
MESH:D004487 Edema pirinixic acid 15.4812083418
MESH:D004487 Edema rosiglitazone 15.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0612538720
MESH:D016889 Endometrial Neoplasms Estradiol 2.9019148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9110568697 9294722
MESH:D004802 Eosinophilia Cyclophosphamide 4.0911006010
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.363659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.3617275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.543922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 9.543922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.4420417680
MESH:D004827 Epilepsy Valproic Acid 6.4418234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 8.496401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.496426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.877750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.877750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.043659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 10.043659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005234 Fatty Liver Cyclosporine 29.1619224547
MESH:D005234 Fatty Liver Dietary Fats 29.1617967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.1615345470
MESH:D005234 Fatty Liver pirinixic acid 29.1620131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 29.1619196556
MESH:D005234 Fatty Liver Valproic Acid 29.1619224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.008888407 18558336
MESH:D005355 Fibrosis Cyclosporine 20.1312168785 12639820
MESH:D005355 Fibrosis Dietary Fats 20.1318296743
MESH:D005355 Fibrosis Emodin 20.1319474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.1320067830
MESH:D005756 Gastritis Acetaminophen 3.5516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.098708960
MESH:D018316 Gliosarcoma Cyclophosphamide 5.3811389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.9015172196 11014644 16376943
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2610048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2915720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.1611918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.4014986274
MESH:D006529 Hepatomegaly Phenobarbital 13.6316109766
MESH:D006529 Hepatomegaly pirinixic acid 13.6319772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.6315340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.037520565
MESH:D006558 Herpes Genitalis Estradiol 4.9015709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.6716135485 17606976
MESH:D019584 Hot Flashes Estradiol 3.6217088409
MESH:D006849 Hydrocephalus Valproic Acid 4.7417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9215340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.5416870215
MESH:D006930 Hyperalgesia rosiglitazone 7.5412083418
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4921332399
MESH:D006973 Hypertension Cyclosporine 8.3010903974
MESH:D006973 Hypertension Dexamethasone 8.3017042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.3018850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6816945680 16569931
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.3118306037
MESH:D007154 Immune System Diseases Cyclophosphamide 5.2016076520
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3412013081
MESH:D007248 Infertility, Male Cyclophosphamide 6.587193160 16517039
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5817937319
MESH:D007249 Inflammation Dexamethasone 11.4511099482 8960868
MESH:D007249 Inflammation Dietary Fats 11.4520412841
MESH:D007249 Inflammation rosiglitazone 11.4512083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.4512878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 16.9618457598 11836018
MESH:D007333 Insulin Resistance Estradiol 16.9616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.9616306350
MESH:D007333 Insulin Resistance rosiglitazone 16.9616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2116580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.3118306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3115604871
MESH:D007674 Kidney Diseases Acetaminophen 9.5415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.548314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.5415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 6.9212371664
MESH:D007680 Kidney Neoplasms Estradiol 6.9215610895
MESH:D007938 Leukemia Cyclophosphamide 3.4310602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4417658394 17802794 18172266 17296974 17008537 18587576
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 4.9017077332
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.9910373061
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1316294345 17596541
MESH:D007970 Leukopenia Cyclophosphamide 4.8310052129 11830472
MESH:D008103 Liver Cirrhosis Dietary Fats 6.4218296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.4221047994
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.5416718785
MESH:D008106 Liver Cirrhosis, Experimental Emodin 8.5415288473
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.5414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.5415474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 8.5415980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.5412878042
MESH:D008107 Liver Diseases Acetaminophen 3.8219784758 11587558 19460945 16611625 12969438 12587719 19014921 16610002
MESH:D008107 Liver Diseases Phenobarbital 3.8219363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1217185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.272125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Phenobarbital 10.278742319 19812893 21047994 19482888 19073162 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 10.2716377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.2716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.358603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.3518308698 17172636 2563599 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.3512151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1317228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.3714755239
MESH:D008175 Lung Neoplasms Dexamethasone 3.3711195469 15824018
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3711884234 19555203
MESH:D008223 Lymphoma Cyclophosphamide 3.7412854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.4716675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.0611911406
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.9711807958 17203775 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 5.9716827153
MESH:D020149 Manganese Poisoning Estradiol 4.3519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 10.4019513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.4016388313
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.2717261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.1018803445 18765137
MESH:D009101 Multiple Myeloma Dexamethasone 3.4115867202 16118317 15744524
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.918888407
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.329809623
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.3217596541
MESH:D009203 Myocardial Infarction Cocaine 5.9118072171
MESH:D009203 Myocardial Infarction pirinixic acid 5.9119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3417484760
MESH:D009369 Neoplasms Cyclophosphamide 4.9618854779
MESH:D009369 Neoplasms pirinixic acid 4.9617405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.0416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.0414600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.0416359493 8888407
MESH:D009447 Neuroblastoma Cyclophosphamide 3.578761367 16115947 15176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7618514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.768761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 4.208291058
MESH:D009765 Obesity Dietary Fats 4.3220132043 16723640 19632207 18457598 20518802 17217161 11836018 21332399 18674790
MESH:D009765 Obesity pirinixic acid 4.3220558911
MESH:D009845 Oligospermia Cyclophosphamide 4.5816517039
MESH:D010018 Osteomalacia Phenobarbital 4.2317016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.1819401270
MESH:D010146 Pain Acetaminophen 6.5016870215
MESH:D010146 Pain Cyclophosphamide 6.5012161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.3911332152
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3916965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.6012371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.602563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 7.5721297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 7.5721297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0311118676 11896295 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.0320603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7620887781
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 3.5117136230
MESH:D011471 Prostatic Neoplasms Estradiol 3.5116740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.1815861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 11.7612752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.7612752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011618 Psychotic Disorders Cocaine 4.7316134406
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2316636934
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.8911700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0519155313
MESH:D012468 Salivary Gland Neoplasms marker/mechanism 16762588
MESH:D012559 Schizophrenia Valproic Acid 2.0519110320 15737665
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.7016636934
MESH:D012640 Seizures Cocaine 9.5210454489
MESH:D012640 Seizures Phenobarbital 9.523137016 16876388 4039156 11442880
MESH:D012640 Seizures Valproic Acid 9.523137016 17978042 14763951 16876388 1511512 15475178 11044598 11738929
MESH:D003294 Seizures, Febrile Phenobarbital 4.696407741
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.398532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8116709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.3816517039
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6819490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4112833885
MESH:D013272 Stomach Diseases Dexamethasone 4.1915472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.3715138204
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.9312837982
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 2.951399818
MESH:D013978 Tibial Fractures Estradiol 4.5619048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.1017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.393119515
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 3.0914692829
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.518888407
MESH:D014581 Urticaria Acetaminophen 2.8510982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1714692618
MESH:D014605 Uveitis Cyclosporine 11.341336536
MESH:D014605 Uveitis Dexamethasone 11.341336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D015430 Weight Gain Dietary Fats 3.6216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3117120751
Pathway ID Pathway Name
REACT:578 Apoptosis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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