AutismKB 2.0

Annotation Detail for GAS8


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Basic Information Top
Gene Symbol:GAS8 ( GAS11,MGC138326 )
Gene Full Name: growth arrest-specific 8
Band: 16q24.3
Quick LinksEntrez ID:2622; OMIM: 605178; Uniprot ID:GAS8_HUMAN; ENSEMBL ID: ENSG00000141013; HGNC ID: 4166
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GAS8 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of GAS8 mRNAincreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GAS8 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of GAS8 mRNAaffects expression 17562736
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of GAS8 mRNAaffects expression 17331233
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of GAS8 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in increased expression of GAS8 mRNAincreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of GAS8 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of GAS8 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.986135515
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.6218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.6218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.6217562736 12958197 11743745 17906064 11739529 14725611 19416960 16227642 16485898 11834606 14550746 16177239 11461765 16081117 19164858 15968718 10774834 19085960 19370779 16781746 18071297 19739265 12594235 11287661 12153990 16109766 11529661 14986274 19420014 10915739 10663392 12705907 12392966 17522070 18713872 19923254 12540782 2444490 16393943 11421492 15619225
MESH:D056486 Drug-Induced Liver Injury Selenium 9.6215131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1316080930
MESH:D006333 Heart Failure Selenium 3.2517162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D007251 Influenza, Human Selenium 12.7616624496
MESH:D007251 Influenza, Human Vitamin E 12.7616624496
MESH:D007674 Kidney Diseases Acetaminophen 6.5115629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.5112488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.2716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2716705839
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6919460945 12587719 19784758 11587558 12969438 16610002 19014921 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.247678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.722876784 2876786 6135515
MESH:D008171 Lung Diseases Vitamin E 3.3716863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.4417365036
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.6816166281 16966607 18303189
MESH:D008654 Mesothelioma Selenium 6.6815107826
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.947678174 18551238
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9216049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9216049721
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.3110923243
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2515084515
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1315814490 17365031 17322281 17975199
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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