AutismKB 2.0

Annotation Detail for GATA1


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Basic Information Top
Gene Symbol:GATA1 ( ERYF1,GATA-1,GF-1,GF1,NFE1,XLTT )
Gene Full Name: GATA binding protein 1 (globin transcription factor 1)
Band: Xp11.23
Quick LinksEntrez ID:2623; OMIM: 305371; Uniprot ID:GATA1_HUMAN; ENSEMBL ID: ENSG00000102145; HGNC ID: 4170
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200070Signaling events mediated by HDAC Class I
200130C-MYB transcription factor network
200019Signaling events mediated by HDAC Class II
200196Notch-mediated HES/HEY network
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1863Aplastic anemia
1983Down syndrome
2051Leukemia
2114Thrombocytopenia
2173Hematopoietic system disease
2188Bone marrow disease
2201Myeloproliferative disease
2239Lymphoma
2259Hereditary disease
Desease Name
megakaryocytic malignancies
macrothrombocytopenia and anemia
No data
Desease Name
Leukemia, megakaryoblastic, of Down syndrome
Leukemia, megakaryoblastic, with or without Down syndrome
Macrothrombocytopenia
Dyserythropoietic anemia with thrombocytopenia
Thrombocytopenia with beta-thalassemia, X-linked
Anemia, X-linked, without thrombocytopenia
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]decreases reaction|increases expression 10656287
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]decreases reaction|increases expression 10656287
D015250 Aclarubicin Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]decreases reaction|increases expression 10656287
D015250 Aclarubicin Aclarubicin promotes the reaction [GATA1 protein binds to GSTP1 promoter]affects binding|increases reaction 14623254
D015250 Aclarubicin Aclarubicin results in increased activity of GATA1 proteinincreases activity 14623254
D015250 Aclarubicin Aclarubicin results in increased expression of GATA1 mRNAincreases expression 10656287
D015250 Aclarubicin pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]decreases reaction|increases expression 10656287
D015250 Aclarubicin Quercetin inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]decreases reaction|increases expression 10656287
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GATA1 mRNAaffects expression 16483693
D001205 Ascorbic Acid [Tretinoin co-treated with Ascorbic Acid] results in increased expression of GATA1 mRNAaffects cotreatment|increases expression 16443354
D020148 Butyric Acid Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]decreases reaction|increases expression 10656287
D020148 Butyric Acid Butyric Acid results in increased expression of GATA1 mRNAincreases expression 10656287
14757314
D020148 Butyric Acid chebulinic acid inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]decreases reaction|increases expression 14769215
D020148 Butyric Acid pyrrolidine dithiocarbamic acid inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]decreases reaction|increases expression 10656287
D020148 Butyric Acid Quercetin inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]decreases reaction|increases expression 10656287
D020148 Butyric Acid tellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]decreases reaction|increases expression 14757314
D002118 Calcium Calcium affects the expression of GATA1 mRNAaffects expression 15913539
D002211 Capsaicin Capsaicin results in increased expression of GATA1 mRNAincreases expression 17603282
C103481 chebulinic acid chebulinic acid inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]decreases reaction|increases expression 14769215
C103481 chebulinic acid chebulinic acid results in decreased expression of GATA1 mRNAdecreases expression 14769215
C014347 decitabine [decitabine co-treated with trichostatin A] results in increased expression of GATA1 mRNAaffects cotreatment|increases expression 17185465
D004317 Doxorubicin Doxorubicin analog results in increased activity of GATA1 proteinincreases activity 17097070
D004317 Doxorubicin Doxorubicin analog results in increased expression of GATA1 mRNAincreases expression 17097070
D004317 Doxorubicin Doxorubicin promotes the reaction [GATA1 protein binds to GSTP1 promoter]affects binding|increases reaction 14623254
D004317 Doxorubicin Doxorubicin results in increased activity of GATA1 proteinincreases activity 14623254
D004317 Doxorubicin Doxorubicin results in increased expression of GATA1 mRNAincreases expression 17097070
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of GATA1 geneincreases mutagenesis 16966598
D018021 Lithium Chloride GATA1 protein results in decreased susceptibility to [Lithium Chloride co-treated with Tretinoin]affects cotreatment|decreases response to substance 19230972
C467566 pomalidomide pomalidomide results in decreased expression of GATA1 mRNAdecreases expression 15292067
C467566 pomalidomide pomalidomide results in decreased expression of GATA1 proteindecreases expression 15292067
C020972 pyrrolidine dithiocarbamic acid pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]decreases reaction|increases expression 10656287
C020972 pyrrolidine dithiocarbamic acid pyrrolidine dithiocarbamic acid inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]decreases reaction|increases expression 10656287
D011794 Quercetin Quercetin inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]decreases reaction|increases expression 10656287
D011794 Quercetin Quercetin inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]decreases reaction|increases expression 10656287
C087926 tellimagrandin I tellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]decreases reaction|increases expression 14757314
C087926 tellimagrandin I tellimagrandin I results in decreased expression of GATA1 mRNAdecreases expression 14757314
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GATA1 mRNAincreases expression 12377990
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GATA1 mRNAdecreases expression 15644576
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate promotes the reaction [GATA1 protein binds to GSTP1 promoter]affects binding|increases reaction 14623254
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased activity of GATA1 proteinincreases activity 14623254
D014212 Tretinoin [Tretinoin co-treated with Ascorbic Acid] results in increased expression of GATA1 mRNAaffects cotreatment|increases expression 16443354
D014212 Tretinoin GATA1 protein results in decreased susceptibility to [Lithium Chloride co-treated with Tretinoin]affects cotreatment|decreases response to substance 19230972
C012589 trichostatin A [decitabine co-treated with trichostatin A] results in increased expression of GATA1 mRNAaffects cotreatment|increases expression 17185465
D014638 Vanadates Vanadates results in increased expression of GATA1 proteinincreases expression 16137666
D015215 Zidovudine Zidovudine results in decreased activity of GATA1 proteindecreases activity 10651068
8599995
D015215 Zidovudine Zidovudine results in decreased expression of GATA1 mRNAdecreases expression 8599995
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 8.2618926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.699612607
MESH:D058186 Acute Kidney Injury Capsaicin 4.4218460982
MESH:D000230 Adenocarcinoma Doxorubicin 2.5417418594
MESH:D000236 Adenoma Ethylnitrosourea 3.646695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2516835633
MESH:D000419 Albuminuria Doxorubicin 4.4221441931
MESH:D000505 Alopecia Capsaicin 9.2317569567
MESH:D000505 Alopecia Tretinoin 9.2315955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.1217084956
MESH:D001169 Arthritis, Experimental Tretinoin 3.0016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Tretinoin 2.3116456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.8515336622
MESH:D001327 Autoimmune Diseases Quercetin 4.2819761891
MESH:D001471 Barrett Esophagus Tretinoin 4.2716935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.5416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5714601052
MESH:D001919 Bradycardia Capsaicin 4.9318207255
MESH:D001927 Brain Diseases Ethylnitrosourea 4.7614991843
MESH:D002545 Brain Ischemia Capsaicin 4.8419211983
MESH:D001932 Brain Neoplasms Doxorubicin 8.7117150277
MESH:D001932 Brain Neoplasms Ethylnitrosourea 8.7116436596 15144691 18412241 16357521 16651633
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.9116443354
MESH:D001943 Breast Neoplasms decitabine 2.9118320071 19208741
MESH:D001943 Breast Neoplasms Doxorubicin 2.9116115903 18695136 15994142 16935488 11325840 15634643 18382427 16264153 17369602 15939500 16322301 19526202 16096432 15136595 15567936 18628466 15668708 15993339 15692762 17426702 17983394 18234424 16826403 16595493
MESH:D001943 Breast Neoplasms Quercetin 2.9118628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9120435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9116166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4616813970
MESH:D002105 Cadmium Poisoning Quercetin 5.4216962696
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0316168501
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.5916234567 17876044 16023760 18059187
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.5919519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.591917145
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.8217234771
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.101485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 13.9717015178
MESH:D002294 Carcinoma, Squamous Cell decitabine 13.9719215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 13.976189445
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 13.9718922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.9716051514 16096774
MESH:D006332 Cardiomegaly Quercetin 6.5619794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5618670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.4417308081 16269455 17007740 15792986 16612575 16364871 15476868 16651473 16242529 16109756 17924179 17351982 15811867 17131338 16278810 16731534 16952015 17329180 16455267 17519947 17928571 18627295 17974986 15505089 17382496
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9017334414 16243910
MESH:D002386 Cataract Tretinoin 3.0217460283
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 7.1218226522
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 7.1216003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.8617160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4616129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002822 Choriocarcinoma Tretinoin 5.0316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5815340226 8697196 15668235 12621046 16354765
MESH:D002972 Cleft Palate Tretinoin 5.589407595
MESH:D003092 Colitis Tretinoin 3.5717035595
MESH:D003110 Colonic Neoplasms decitabine 3.8617616700
MESH:D003110 Colonic Neoplasms Quercetin 3.8617148506 19056647 11134977 15741050 17191121 19440933 16640504
MESH:D015179 Colorectal Neoplasms decitabine 3.4718981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.4718802399 18259882
MESH:D015179 Colorectal Neoplasms Quercetin 3.4718095365 18852136
MESH:D003139 Common Cold Ascorbic Acid 5.3517323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9514669216 17141729
MESH:D003371 Cough Capsaicin 5.0510350223
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4120055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4110589399 9142499 16925845 9224671 17551590 9211117 9125849 8800419 9664655 14991402
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.2619747007
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.6219496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 4.4516506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4517107852
MESH:D004314 Down Syndrome marker/mechanism
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 6.1511287661
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.1517416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1520420201
MESH:D004362 Drug Toxicity Doxorubicin 13.2318602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.2311462148
MESH:D004362 Drug Toxicity Zidovudine 13.2315040536
MESH:D004381 Duodenal Ulcer Capsaicin 4.5610671773 11535926
OMIM:300367 DYSERYTHROPOIETIC ANEMIA WITH THROMBOCYTOPENIA marker/mechanism
MESH:C538011 Eales disease Ascorbic Acid 5.359068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.8618357618
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5611000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 6.568273558 9599246 8113982 16716910 7812673 11698051 15177302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5116714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.5118230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.6019294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.6019294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.3017359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.3016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9110568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0318037988
MESH:D004935 Esophageal Diseases Capsaicin 5.5719566590
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.519664655 16938888
MESH:D005234 Fatty Liver Zidovudine 3.7918299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4619069698
MESH:D005355 Fibrosis Quercetin 14.0719474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.0720067830
MESH:D005355 Fibrosis Tretinoin 14.0717994277
MESH:D005909 Glioblastoma Capsaicin 26.6718405923
MESH:D005909 Glioblastoma Doxorubicin 26.6717150277
MESH:D005909 Glioblastoma Ethylnitrosourea 26.6716436596
MESH:D005909 Glioblastoma Quercetin 26.6719804834
MESH:D005909 Glioblastoma Tretinoin 26.6717312396
MESH:D005909 Glioblastoma trichostatin A 26.6718801729
MESH:D005910 Glioma Ethylnitrosourea 6.2416651633 18412241 16357521
MESH:D005910 Glioma Quercetin 6.2417643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006258 Head and Neck Neoplasms decitabine 12.4819215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.4815692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.4816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0316084493
MESH:D006356 Heartburn Capsaicin 5.5719566590
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 10.8416080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.8410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.849664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.3914766674 16330681 16879835 16144979 16244372 18674790 18006777 16244371 16495754 12587719 17875725 16707910 17888722
MESH:D006333 Heart Failure Doxorubicin 3.2617481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7815692506
MESH:D006402 Hematologic Diseases Zidovudine 4.5912579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7615340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.4316863852 16490937
MESH:D015658 HIV Infections Zidovudine 3.4211363243 20032539 17358032 11141242 11698656
MESH:D006689 Hodgkin Disease Doxorubicin 3.3018501091 15147373 17606976
MESH:D006869 Hydronephrosis Lithium Chloride 12.6019797860
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 12.6016959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Capsaicin 7.8817043245 17434803
MESH:D006930 Hyperalgesia Tretinoin 7.8816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4416778211
MESH:D006943 Hyperglycemia Quercetin 3.9218262572 11834736
MESH:D006973 Hypertension Quercetin 5.0618356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0618850075 18670907
MESH:D007248 Infertility, Male decitabine 3.1217581917
MESH:D007249 Inflammation Capsaicin 8.1316956363
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1312878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 8.1315177302 7812673 11698051 8273558 7562506
MESH:D007251 Influenza, Human pyrrolidine dithiocarbamic acid 11.1418473937
MESH:D007251 Influenza, Human Quercetin 11.1416624496
MESH:D007410 Intestinal Diseases Tretinoin 3.6417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5316580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5315992940 17551590
MESH:D007627 Keloid Quercetin 4.8217086741
MESH:D007674 Kidney Diseases Doxorubicin 6.1415369732 16775033 15699352
MESH:D007674 Kidney Diseases Quercetin 6.1416962696
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0316707910
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 7.6517379185
MESH:D007680 Kidney Neoplasms Zidovudine 7.6512579204
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.9216316344
MESH:D007938 Leukemia decitabine 10.1718980019 19235587
MESH:D007938 Leukemia Quercetin 10.1717468513
MESH:D007938 Leukemia Tretinoin 10.1717143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0316085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.2920370541
MESH:D007951 Leukemia, Myeloid decitabine 9.1619117987 18454857 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 9.1619285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.1118460780 19387464 19010910 18206229 17679729 18704418
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.1117596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.1118206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3318055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0716766008 17301526 17217047 19029980 17107899 16331271 17368321 16935935 9834237 15748426 19075265 19225113 17294898 16140955 17712046 17361223 17339181 19642359 16891316 16788101 12679006 17506722 17649720 19035177 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.219224671
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.6016595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pyrrolidine dithiocarbamic acid 6.6015078482
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.6012741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.6016248980 18397230
MESH:D008107 Liver Diseases Capsaicin 3.2316956363
MESH:D008113 Liver Neoplasms Quercetin 4.4018980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4016984957
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 13.5218544905
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.5216842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Quercetin 13.5219519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.5212151625
MESH:D008171 Lung Diseases Acetylcysteine 7.7612815614
MESH:D008171 Lung Diseases Ascorbic Acid 7.7616863852
MESH:D055370 Lung Injury pyrrolidine dithiocarbamic acid 4.8616129981
MESH:D008175 Lung Neoplasms Ascorbic Acid 10.4716401635
MESH:D008175 Lung Neoplasms Doxorubicin 10.476189445 17418594
MESH:D008175 Lung Neoplasms Ethylnitrosourea 10.4716271038 6695378 16019985 17703301
MESH:D008175 Lung Neoplasms Quercetin 10.4716280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.4711884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 10.4711807781
MESH:D008175 Lung Neoplasms Zidovudine 10.4718800350
MESH:D008223 Lymphoma decitabine 12.1619470736
MESH:D008223 Lymphoma Doxorubicin 12.1616098063
MESH:D008223 Lymphoma Ethylnitrosourea 12.1615790496
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 11.2615621674
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 11.2615375218
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.7315458769
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 9.7310767621 18041768 10838139
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 9.738985016
MESH:D008527 Medulloblastoma Tretinoin 2.7317453147
MESH:D008545 Melanoma decitabine 7.1716505122 17785578
MESH:D008545 Melanoma Doxorubicin 7.1716827129
MESH:D008545 Melanoma Tretinoin 7.1716752155
MESH:D008545 Melanoma trichostatin A 7.1716505122
MESH:D008579 Meningioma Ethylnitrosourea 5.8617943659
MESH:D008591 Meningomyelocele Tretinoin 4.2916940565
MESH:D008654 Mesothelioma Doxorubicin 3.0117638057
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.7117358032
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3815792986
MESH:D052016 Mucositis Doxorubicin 4.6617415656
MESH:D009101 Multiple Myeloma Capsaicin 11.8417505005
MESH:D009101 Multiple Myeloma decitabine 11.8418172295
MESH:D009101 Multiple Myeloma trichostatin A 11.8418172295
MESH:D009190 Myelodysplastic Syndromes decitabine 7.2318608210 19157545 16882708 19010910
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.2317596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.8415857846 19429709
MESH:D009203 Myocardial Infarction Quercetin 5.8419595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.6919207477
MESH:D009362 Neoplasm Metastasis Acetylcysteine 6.0814720322
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.0818259882
MESH:D009369 Neoplasms decitabine 8.0019116145 19470736 17925555
MESH:D009369 Neoplasms Quercetin 8.0015185748
MESH:D009369 Neoplasms Tretinoin 8.0016946489 16594593
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.2716707424
MESH:D009401 Nephrosis Doxorubicin 4.6416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8915640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.0914600291
MESH:D009421 Nervous System Malformations Tretinoin 9.099125849
MESH:D009436 Neural Tube Defects Acetylcysteine 7.3519446573
MESH:D009436 Neural Tube Defects Tretinoin 7.359142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.2817160924 16003739 16651423
MESH:D009447 Neuroblastoma Doxorubicin 3.2015555623
MESH:D020078 Neurogenic Inflammation Capsaicin 10.5317961222
MESH:D020078 Neurogenic Inflammation Quercetin 10.5317929310
MESH:D009765 Obesity Ascorbic Acid 5.2217217161
MESH:D009765 Obesity Capsaicin 5.2219056576
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.8617160924
MESH:D010024 Osteoporosis Calcium 3.7017882678
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.0919495926
MESH:D012516 Osteosarcoma Doxorubicin 4.0115930896
MESH:D010051 Ovarian Neoplasms decitabine 11.0219331143 19259094
MESH:D010051 Ovarian Neoplasms Quercetin 11.0219005980
MESH:D010051 Ovarian Neoplasms Tretinoin 11.0216936753
MESH:D010051 Ovarian Neoplasms trichostatin A 11.0219331143
MESH:D010146 Pain Capsaicin 6.8317434803 17043245 16996476 19081190 18987195 17084039
MESH:D010146 Pain Tretinoin 6.8316870215
MESH:D010190 Pancreatic Neoplasms decitabine 15.8519294695
MESH:D010190 Pancreatic Neoplasms Quercetin 15.8516965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 15.8515976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.8515976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 15.8519294695
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.1618922899 12065085 18404319 8330346
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0317638057
MESH:D011141 Polyuria Lithium Chloride 5.8719692487
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Quercetin 3.8719056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0611222880 11118676 11896295 11399792
MESH:D055728 Primary Myelofibrosis decitabine 11.9917616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.9917616702
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.2416868541 15897917 16888761 15749863 18437689 16729912
MESH:D011471 Prostatic Neoplasms pyrrolidine dithiocarbamic acid 2.2416139439
MESH:D011471 Prostatic Neoplasms Quercetin 2.2417292933 14715546
MESH:D011471 Prostatic Neoplasms trichostatin A 2.2419789329 18798265
MESH:D011507 Proteinuria Tretinoin 3.4816636307
MESH:D011625 Pterygium Tretinoin 4.6616723453
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.2014606601
MESH:D051437 Renal Insufficiency Doxorubicin 4.0917922066
MESH:D015427 Reperfusion Injury Capsaicin 3.9019211983 18460982
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 9.4412210543
MESH:D012128 Respiratory Distress Syndrome, Adult pyrrolidine dithiocarbamic acid 9.4416129981
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2716849425
MESH:D012208 Rhabdomyosarcoma decitabine 10.5319155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.5316116481 16283617
MESH:D012509 Sarcoma Doxorubicin 3.8715675481 16767912 18313854 17203757 17710206 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1114601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6617846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.4216862918
MESH:D012871 Skin Diseases Ascorbic Acid 3.1818709164
MESH:D012878 Skin Neoplasms Doxorubicin 13.1015692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.1016192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 13.108330346 8985016 18404319 11807781 12065085
MESH:D012878 Skin Neoplasms Tretinoin 13.1016467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4417203757 15625365 16767912
MESH:D013274 Stomach Neoplasms decitabine 3.4319037991
MESH:D013274 Stomach Neoplasms Tretinoin 3.4317261132
MESH:D013274 Stomach Neoplasms Zidovudine 3.4317696246
MESH:D013276 Stomach Ulcer Acetylcysteine 7.4717918041
MESH:D013276 Stomach Ulcer Ascorbic Acid 7.4718726076
MESH:D020521 Stroke Ascorbic Acid 4.1916403987 16517955
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.5917997062
MESH:D013921 Thrombocytopenia marker/mechanism 16966598
OMIM:314050 THROMBOCYTOPENIA, PLATELET DYSFUNCTION, HEMOLYSIS, AND IMBALANCED GLOBIN SYNTHESIS marker/mechanism
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.0315790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms decitabine 11.4817967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.4817909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 11.4817045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.6716051514
MESH:D014376 Tuberculosis Tretinoin 3.1516040207
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.1719087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.1717653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.1716720314
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5616129372
MESH:D014604 Uveal Neoplasms decitabine 12.4017785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.4016752155
MESH:D014625 Vaginal Neoplasms Zidovudine 4.6312579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0917334414 16364871 17678736 17638931
MESH:D014820 Vitiligo Tretinoin 3.9316761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D009396 Wilms Tumor Tretinoin 3.8516287080
Pathway ID Pathway Name
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28584
    • No data
    No data
    Releated drug ID Related drug Name
    PA449789glycine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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