AutismKB 2.0

Annotation Detail for FBXL5


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Basic Information Top
Gene Symbol:FBXL5 ( FBL4,FBL5,FLR1 )
Gene Full Name: F-box and leucine-rich repeat protein 5
Band: 4p15.32
Quick LinksEntrez ID:26234; OMIM: 605655; Uniprot ID:FBXL5_HUMAN; ENSEMBL ID: ENSG00000118564; HGNC ID: 13602
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of proteins
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of FBXL5 mRNAaffects expression 17562736
D001151 Arsenic Arsenic affects the expression of FBXL5 mRNAaffects expression 18414638
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of FBXL5 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FBXL5 mRNAdecreases expression 19150397
D012402 Rotenone Rotenone results in increased expression of FBXL5 mRNAincreases expression 19013527
D012643 Selenium Selenium results in decreased expression of FBXL5 mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of FBXL5 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018246 Adrenocortical Adenoma Arsenic 5.6617306315
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D020261 Arsenic Poisoning Arsenic 2.9316835338 12569548 16251483 18414634
MESH:D050197 Atherosclerosis Arsenic 3.4019371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7317687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.123084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.1217306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.9418922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9420419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3418640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6315738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.5616973168 18022660
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1115894690
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0316285004
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6514725611 16485898 19416960 19923254 19739265 12392966 16781746 10663392 11461765 12153990 16081117 19370779 19085960 15619225 15968718 19164858 12958197 17562736 17522070 18713872 16177239 11529661 11834606 11739529 17906064 12540782 18071297 2444490 11421492 10774834 10915739 16393943 11287661 12594235 16109766 14550746 12705907 16227642 19420014 11743745 14986274
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6515131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.6515131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5416530937
MESH:D005534 Foot Diseases Arsenic 6.006392382
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7217050553
MESH:D006973 Hypertension Arsenic 2.9516076760 11953799 9931084
MESH:D006987 Hypesthesia Arsenic 6.0016093927
MESH:D007251 Influenza, Human Selenium 4.6416624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.4514714311
MESH:D007642 Keratosis Arsenic 5.3916930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7217339181
MESH:D008107 Liver Diseases Acetaminophen 4.2619784758 16610002 19460945 12969438 11587558 16611625 12587719 19014921
MESH:D008107 Liver Diseases Arsenic 4.2611134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 4.9816368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.9821137059 20195826
MESH:D008175 Lung Neoplasms Arsenic 2.6019168569 17306315 17976673
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.6018569708 17053015 20464547 20135361 18816296 20869020 20064080 6695378 18520028
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3614737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9215318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D017202 Myocardial Ischemia Arsenic 4.2115371236
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009410 Nerve Degeneration Rotenone 4.0918619942 17356569 15790535
MESH:D009436 Neural Tube Defects Arsenic 3.6216620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.6817056641
MESH:D010051 Ovarian Neoplasms Arsenic 2.8117306315
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010300 Parkinson Disease Rotenone 3.0616140633 19232380 18619942 18191903 16412576 15451049 11445065 11535288 19114014
MESH:D020734 Parkinsonian Disorders Rotenone 4.3418197244 15795934 15574749 15927086
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3915371236 6392382 16905509
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D011471 Prostatic Neoplasms Arsenic 2.5616140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5617292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5618760546
MESH:D011507 Proteinuria Arsenic 4.3121343184
MESH:D012871 Skin Diseases Arsenic 2.8018709164 19834688 17050553 6392382 16353154 17453740 16759981 16702368 15952646 17938729 17548696
MESH:D012878 Skin Neoplasms Arsenic 6.2117029826 15504454 17976673 16251483 17050553 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.2119755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.4715987713 11144890 17306315 17976673 19429237 19322015 18640142
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4717053015
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014652 Vascular Diseases Arsenic 5.1317056641
Pathway ID Pathway Name
REACT:17015 Metabolism of proteins
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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