AutismKB 2.0

Annotation Detail for FBXL4


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Basic Information Top
Gene Symbol:FBXL4 ( FBL4,FBL5 )
Gene Full Name: F-box and leucine-rich repeat protein 4
Band: 6q16.1-q16.2
Quick LinksEntrez ID:26235; OMIM: 605654; Uniprot ID:FBXL4_HUMAN; ENSEMBL ID: ENSG00000112234; HGNC ID: 13601
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of FBXL4 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of FBXL4 mRNAincreases expression 20458559
D004041 Dietary Fats Dietary Fats results in decreased expression of FBXL4 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of FBXL4 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FBXL4 mRNAaffects binding|increases activity|increases expression 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3511798837 19825857
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.3715238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.2716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.2719483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7311589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.023084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.0211135700 16217749 15553829 14691202 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4712490120
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6312609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6619416960 11529661 17522070 14550746 16227642 11743745 11287661 11739529 15968718 12540782 16781746 17906064 11834606 12594235 14725611 15619225 19739265 10774834 17562736 19923254 19370779 2444490 14986274 18713872 10915739 12153990 18071297 19420014 12705907 19164858 11461765 12392966 12958197 10663392 11421492 19085960 16393943 16109766 16485898 16081117 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D050171 Dyslipidemias Dietary Fats 3.7018367378
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3812903497
MESH:D005234 Fatty Liver arsenic trioxide 15.3815073043
MESH:D005234 Fatty Liver Dietary Fats 15.3818296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver pirinixic acid 15.3819236843 20131406
MESH:D005355 Fibrosis Dietary Fats 4.0118296743
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7016904648
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4816221962 18467677 19772884 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006949 Hyperlipidemias Dietary Fats 4.0221332399
MESH:D007249 Inflammation Dietary Fats 2.5920412841
MESH:D007333 Insulin Resistance Dietary Fats 7.9718457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.9716306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D007938 Leukemia arsenic trioxide 2.9815070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.8516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1816467208 19850784 20471514 16968895 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4319225113 15622746 16966277 12018890 11161223 15748426 16823087 17869043 12679006 16331271 16891316 17217047 17712046 17649720 19075265 12712474 16330433 17107899 15213294 19035177 9834237 11468182 16112521 15336539 19642359
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7916882451
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0518296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6916611625 19460945 11587558 12969438 12587719 19014921 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 4.8414682389
MESH:D008113 Liver Neoplasms pirinixic acid 4.8416377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9320377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6215213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3519417148 19549372 15949261 11468182 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.2818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3216882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4016624393
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3310525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity Dietary Fats 4.6718674790 17217161 11836018 21332399 20518802 20132043 16723640 19632207 18457598
MESH:D009765 Obesity pirinixic acid 4.6720558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4916624393 19769630 12452020
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6215580305
MESH:D010235 Paraganglioma arsenic trioxide 4.5719927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4016646077
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3619014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5911780464 20435036 12973940 12845720
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D015430 Weight Gain Dietary Fats 4.0616723640
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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