AutismKB 2.0

Annotation Detail for GATA3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GATA3 ( HDR,MGC2346,MGC5199,MGC5445 )
Gene Full Name: GATA binding protein 3
Band: 10p14
Quick LinksEntrez ID:2625; OMIM: 131320; Uniprot ID:GATA3_HUMAN; ENSEMBL ID: ENSG00000107485; HGNC ID: 4172
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200039Calcineurin-regulated NFAT-dependent transcription in lymphocytes
200002Regulation of nuclear SMAD2/3 signaling
200130C-MYB transcription factor network
200013Notch signaling pathway
200077Glucocorticoid receptor regulatory network
200023IL27-mediated signaling events
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1779Cervical cancer
1807Autoimmune disease
1863Aplastic anemia
1944Breast cancer
1841Stomach cancer
2017Atopic rhinitis
2074Asthma
2106Pancreas cancer
2146Lupus erythematosus
2207Deafness
2220Dermatitis
2239Lymphoma
Desease Name
Asthma
IMMUNE
No data
Desease Name
Hypoparathyroidism, sensorineural deafness, and renal dysplasia
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of GATA3 mRNAdecreases expression 12419474
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of GATA3 proteinincreases activity 16835749
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GATA3 mRNAincreases expression 16835749
16582591
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone Bungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of GATA3 protein]decreases reaction|increases activity 16835749
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone Mecamylamine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of GATA3 protein]decreases reaction|increases activity 16835749
D000082 Acetaminophen Acetaminophen affects the expression of GATA3 mRNAaffects expression 17562736
C430898 AGN 194204 AGN 194204 results in increased expression of GATA3 mRNAincreases expression 16339527
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GATA3 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide inhibits the reaction [GATA3 protein binds to IL13 promoter]affects binding|decreases reaction 19080345
C006632 arsenic trioxide arsenic trioxide inhibits the reaction [GATA3 protein binds to KPNA2 protein]affects binding|decreases reaction 19080345
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GATA3 mRNAaffects cotreatment|decreases expression 18164116
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GATA3 mRNAdecreases expression 17944540
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in decreased expression of GATA3 mRNAdecreases expression 15912405
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of GATA3 mRNAincreases expression 17553608
D002038 Bungarotoxins Bungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of GATA3 protein]decreases reaction|increases activity 16835749
D002038 Bungarotoxins Bungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased activity of GATA3 protein]decreases reaction|increases activity 16835749
D002038 Bungarotoxins Bungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased expression of GATA3 mRNA]decreases reaction|increases expression 16835749
C014347 decitabine [decitabine co-treated with trichostatin A] results in decreased expression of GATA3 mRNAaffects cotreatment|decreases expression 17891453
D013759 Tetrahydrocannabinol SR 144528 inhibits the reaction [Tetrahydrocannabinol results in increased expression of GATA3 mRNA]decreases reaction|increases expression 14741435
D013759 Tetrahydrocannabinol Tetrahydrocannabinol results in increased expression of GATA3 mRNAincreases expression 14741435
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GATA3 mRNAaffects cotreatment|decreases expression 18164116
D004391 Dust Dust results in increased expression of GATA3 mRNAincreases expression 17805423
D007052 Ibuprofen Ibuprofen results in decreased expression of GATA3 mRNAdecreases expression 17630191
C051890 irinotecan irinotecan metabolite results in decreased expression of GATA3 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of GATA3 mRNAdecreases expression 15956246
D008464 Mecamylamine Mecamylamine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of GATA3 protein]decreases reaction|increases activity 16835749
D008464 Mecamylamine Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased activity of GATA3 protein]decreases reaction|increases activity 16835749
D008464 Mecamylamine Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of GATA3 mRNA]decreases reaction|increases expression 16835749
C008655 N'-nitrosonornicotine Bungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased activity of GATA3 protein]decreases reaction|increases activity 16835749
C008655 N'-nitrosonornicotine Bungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased expression of GATA3 mRNA]decreases reaction|increases expression 16835749
C008655 N'-nitrosonornicotine Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased activity of GATA3 protein]decreases reaction|increases activity 16835749
C008655 N'-nitrosonornicotine Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of GATA3 mRNA]decreases reaction|increases expression 16835749
C008655 N'-nitrosonornicotine N'-nitrosonornicotine results in increased activity of GATA3 proteinincreases activity 16835749
C008655 N'-nitrosonornicotine N'-nitrosonornicotine results in increased expression of GATA3 mRNAincreases expression 16582591
16835749
D010126 Ozone Ozone results in decreased expression of GATA3 mRNAdecreases expression 17460151
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GATA3 mRNAaffects binding|decreases expression|increases activity 19710929
C116926 rofecoxib rofecoxib results in decreased expression of GATA3 mRNAdecreases expression 17070997
C017947 sodium arsenite sodium arsenite results in decreased expression of GATA3 mRNAdecreases expression 12634122
D018038 Sodium Selenite Sodium Selenite results in increased expression of GATA3 mRNAincreases expression 18175754
C110630 SR 144528 SR 144528 inhibits the reaction [Tetrahydrocannabinol results in increased expression of GATA3 mRNA]decreases reaction|increases expression 14741435
D013619 Tacrine Tacrine results in increased expression of GATA3 mRNAincreases expression 12832660
D013629 Tamoxifen ESR1 protein affects the reaction [GATA3 protein affects the susceptibility to Tamoxifen]affects reaction|affects response to substance 19084267
D013629 Tamoxifen Tamoxifen results in increased expression of GATA3 mRNAincreases expression 19031437
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GATA3 mRNAincreases expression 18684927
D014212 Tretinoin Tretinoin results in increased expression of GATA3 mRNAincreases expression 17118196
17138961
C012589 trichostatin A [decitabine co-treated with trichostatin A] results in decreased expression of GATA3 mRNAaffects cotreatment|decreases expression 17891453
C015559 trimellitic anhydride trimellitic anhydride results in increased expression of GATA3 mRNAincreases expression 20219652
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D058186 Acute Kidney Injury Ibuprofen 4.196375363
MESH:D055371 Acute Lung Injury pirinixic acid 2.8518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5511798837 19825857
MESH:D000230 Adenocarcinoma Ibuprofen 4.5510697514
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.3816176798
MESH:D000236 Adenoma beta-Naphthoflavone 10.3819389873
MESH:D000236 Adenoma Diethylnitrosamine 10.386695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.5618056438 19052882 17162532 17620307 16434500 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.5616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6017306315 16712894
MESH:D000437 Alcoholism Mecamylamine 5.4120201817
MESH:D000505 Alopecia Tretinoin 3.3815955085
MESH:D000544 Alzheimer Disease Ibuprofen 6.5618351690
MESH:D000544 Alzheimer Disease Ozone 6.5615513908
MESH:D000544 Alzheimer Disease Tacrine 6.5612725862
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 8.1210965797
MESH:D000690 Amyotrophic Lateral Sclerosis Tetrahydrocannabinol 8.1215204022
MESH:D000707 Anaphylaxis Ibuprofen 4.969532969
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6911748828
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D001169 Arthritis, Experimental rofecoxib 7.2216690336
MESH:D001169 Arthritis, Experimental Tretinoin 7.2216412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.4215570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4216292516
MESH:D001249 Asthma Ozone 7.5617854713 16373670
MESH:D001249 Asthma Tretinoin 7.5616456186
MESH:D001249 Asthma trimellitic anhydride 7.5616141432
MESH:D050197 Atherosclerosis Tetrahydrocannabinol 4.3015815632
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1216935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 19.7816206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 19.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 19.7812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 19.7816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D002545 Brain Ischemia Ibuprofen 4.5915837124
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 2.8120146248
MESH:D001943 Breast Neoplasms decitabine 2.8118320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8117474063
MESH:D001943 Breast Neoplasms Tamoxifen 2.8121152245 16202921 19244106 18821012 20859285 20065188 17242785 18997820 19103187 18855134 20005174 18629630 19059307 19011961 17440819 19084267 19410462 20544844 19200415 11161223 19289846 19189212 19066611 19155303 17261762 19189210 20390343 18351453 19288272 19142967 17049068 19115204 16873071 17893378 19487384 18815881 16818667 15565566 18984771 19221464 18425577 15668708 21138602 20135344 16273361
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8120435547
MESH:D001943 Breast Neoplasms Tretinoin 2.8116443354 16166294 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4519059883 18417511 14754758 17626835 16777450 18315731 15516495
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2916813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0611589617
MESH:D002100 Cachexia Ibuprofen 11.5815141370
MESH:D002100 Cachexia Ozone 11.5816183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5716835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8616168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.703084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 10.7015553829 16217749 15073043 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.7016569478 18978308 18691550 21159647 20432363 19519916 3084413 19822196 10672840 19418558 18788625 18665156 20727157 16807293 17055752 19383236 18494052 18971187 20101231 18785209 19208518 16779866 16878318 10737359 16502159 16830150 17761372 16540662 18210153 20512989 20214788 3581430 16328049 20007298 18056438 19335982 19052882 16698587 16935385 19394651 18393292 19107877 16681979 17162532 20514400 20084675 18506893 17138121 19701751 16288022 19919837 20935162 19171122 11831363 17978847 17428255 17173139 20524982 19539802
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.7016507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.7016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.701917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8612490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.0519215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.0518572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.0516096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2116120746 18670907 18850075
MESH:D002375 Catalepsy Tetrahydrocannabinol 5.4310318961
MESH:D002386 Cataract Acetaminophen 6.6510977129
MESH:D002386 Cataract Tretinoin 6.6517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.0420889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.0417174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.0420056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2916129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5016835633
MESH:D002779 Cholestasis pirinixic acid 2.6119176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8616461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.4615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3515668235 8697196 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.359407595
MESH:D003092 Colitis Tretinoin 3.4217035595
MESH:D003110 Colonic Neoplasms decitabine 5.7117616700
MESH:D003110 Colonic Neoplasms irinotecan 5.7117725105 17287894
MESH:D003110 Colonic Neoplasms rofecoxib 5.7112902858
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.3620501625
MESH:D015179 Colorectal Neoplasms decitabine 3.3618981723
MESH:D015179 Colorectal Neoplasms irinotecan 3.3616303861 18259882 18509181 17159606 17454858 16391804 15273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.5610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5620055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.569224671 10589399 9211117 17551590 16925845 8800419 14991402 9125849 9142499 9664655
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0719031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.5316285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.9620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.2319279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.1912705907 16081117 19370779 11461765 10774834 12958197 18713872 10915739 12540782 14725611 2444490 11287661 16393943 19739265 11739529 16781746 11743745 11834606 10663392 16109766 14550746 14986274 17562736 19085960 19923254 17906064 15619225 16227642 12392966 16177239 12153990 18071297 11529661 19416960 16485898 12594235 15968718 11421492 19420014 19164858 17522070
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.1919107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 8.1915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.1920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5511462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.3216133044 18446180 18450898
MESH:D004487 Edema pirinixic acid 5.6812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.6811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.9415322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.9418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.2619031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.0319294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.0319294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.8016202921 19155303 17893378 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 6.8016569247
MESH:D004715 Endometriosis Ibuprofen 14.0415652904
MESH:D004715 Endometriosis rofecoxib 14.0415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.049294722 10568697
MESH:D019446 Endotoxemia Ibuprofen 4.6711545620
MESH:D004827 Epilepsy Tetrahydrocannabinol 4.33821787
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1920426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.1912903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.1116938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 16.6115073043
MESH:D005234 Fatty Liver Diethylnitrosamine 16.6120387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 16.6120131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 16.6114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005334 Fever Ibuprofen 4.3316997862
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8919069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.6620067830
MESH:D005355 Fibrosis Tretinoin 7.6617994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9816904648
MESH:D005756 Gastritis Acetaminophen 3.3816983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3816452187
MESH:D005909 Glioblastoma Tretinoin 6.7817312396
MESH:D005909 Glioblastoma trichostatin A 6.7818801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.1719215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.1716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0210048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.029664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.3620558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006529 Hepatomegaly pirinixic acid 7.3019176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3016120746 15340226 12621046
MESH:D006689 Hodgkin Disease marker/mechanism 21037568
MESH:D006689 Hodgkin Disease sodium arsenite 2.9112676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7516959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 6.8616870215
MESH:D006930 Hyperalgesia Tretinoin 6.8616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2816778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8018850075 18670907
MESH:D006984 Hypertrophy Ibuprofen 4.7116672835
OMIM:146255 HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE marker/mechanism
MESH:D007035 Hypothermia Tetrahydrocannabinol 5.6310318961
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.5416133044
MESH:D007248 Infertility, Male decitabine 6.2617581917
MESH:D007248 Infertility, Male sodium arsenite 6.2612646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 10.7118785209
MESH:D007249 Inflammation Ibuprofen 10.713291741
MESH:D007249 Inflammation Tamoxifen 10.7119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.7112200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 6.6716306350
MESH:D007333 Insulin Resistance Sodium Selenite 6.6714714311
MESH:D007410 Intestinal Diseases rofecoxib 9.1815831440
MESH:D007410 Intestinal Diseases Tretinoin 9.1817994277
MESH:D007417 Intestinal Polyps rofecoxib 5.1011245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.0516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.0515992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 5.4015629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 5.4020008137
MESH:D007680 Kidney Neoplasms Tamoxifen 2.8118625569
MESH:D007938 Leukemia arsenic trioxide 9.6415070760
MESH:D007938 Leukemia decitabine 9.6419235587 18980019
MESH:D007938 Leukemia Tretinoin 9.6417143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 14.4719077051
MESH:D007951 Leukemia, Myeloid decitabine 14.4717236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 14.4716932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 8.3016467208 16968895 19850784 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute decitabine 8.3018460780 18206229 17679729 19387464 19010910 18704418
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 8.3017596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 8.3018206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1618055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.0016891316 15622746 15213294 19075265 17712046 12679006 17649720 16966277 12712474 17869043 19035177 15748426 11468182 19225113 16112521 15336539 16823087 16330433 9834237 12018890 17107899 16331271 19642359 11161223 17217047
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.0016766008 17712046 17217047 16331271 15748426 19642359 19029980 19075265 16891316 17361223 17506722 17107899 17368321 16788101 16935935 17294898 17649720 19035177 16140955 9834237 17301526 16823087 19225113 17339181 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0716882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.109224671
MESH:D008064 Lipidoses Tamoxifen 2.9517567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.6620032147 18407596 18522880 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3215474484
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 6.3217565644
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.3218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.3218397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.6412969438 11587558 19014921 19460945 19784758 16611625 12587719 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 3.6417034775
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9816871587 17185352
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 23.9315890375
MESH:D008113 Liver Neoplasms arsenic trioxide 23.9314682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 23.9319389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 23.9318648771 20583210 19426721 20492335 19638242 10737359 15885732 2862719 21278145 19090486 18644402 20434301 12771043 20405173 18977376 20118626 19499222 19427195 19294768 19850985 18754104 21071580 20452335 21167192 20101389 19642983 19254457 20501860 19812893 21047994 20137499 19833225 15175105 18978307 19256749 19255062 12112319 19073162 9163691 19996281 19690152 2422723 19551842 16942905
MESH:D008113 Liver Neoplasms pirinixic acid 23.9320007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 23.9316712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 23.9316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.9316984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 12.6220377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 12.6218164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.6221159647 18079962 9362446 19004024 16842330 19009564 18308698 19539802 3124819 18775883 17854601 16267830 19126423 18544905 18093689 18253720 19519916 18164116 17174075 2563599 17942915 18282651
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.6212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1315213294
MESH:D008171 Lung Diseases Ozone 6.8619066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 6.8619095001
MESH:D055370 Lung Injury Ozone 3.5620417186
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.0915893417 9255578 18508827 17139156 14755239 18813816 19931552 15172992 12438228 16401635 16061637
MESH:D008175 Lung Neoplasms arsenic trioxide 10.0911798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.0920512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Ozone 10.098597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 10.0916712894 17077188 17306315 19931552 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 10.0918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.0919555203 11884234
MESH:D008223 Lymphoma decitabine 3.2119470736
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.7914737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4719428831
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 5.7710697514
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.7714580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.2519453300
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma decitabine 9.1916505122 17785578
MESH:D008545 Melanoma sodium arsenite 9.1916487513 19082730
MESH:D008545 Melanoma Tamoxifen 9.1912393984 19393235
MESH:D008545 Melanoma Tretinoin 9.1916752155
MESH:D008545 Melanoma trichostatin A 9.1916505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D008591 Meningomyelocele Tretinoin 4.1416940565
MESH:D008679 Metaplasia Ozone 4.8110496685
MESH:D052016 Mucositis irinotecan 4.7117159606
MESH:D009101 Multiple Myeloma arsenic trioxide 11.0319417148 11468182 15949261 19549372 14977855
MESH:D009101 Multiple Myeloma decitabine 11.0318172295
MESH:D009101 Multiple Myeloma trichostatin A 11.0318172295
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 11.3616882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 11.3619157545 16882708 19010910 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.3617596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7216411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6816624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.853581430 9029167
MESH:D009362 Neoplasm Metastasis irinotecan 8.8518259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.8519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms decitabine 10.6419116145 17925555 19470736
MESH:D009369 Neoplasms pirinixic acid 10.6417405874
MESH:D009369 Neoplasms sodium arsenite 10.6411559025
MESH:D009369 Neoplasms Tretinoin 10.6416594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3820056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7019189210 19196722 19200415
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.696375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.1610961664
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5814600291
MESH:D009421 Nervous System Malformations Tretinoin 8.589125849
MESH:D009436 Neural Tube Defects arsenic trioxide 15.8410525206
MESH:D009436 Neural Tube Defects sodium arsenite 15.8412854658
MESH:D009436 Neural Tube Defects Tetrahydrocannabinol 15.8419040278
MESH:D009436 Neural Tube Defects Tretinoin 15.849142499
MESH:D009447 Neuroblastoma irinotecan 3.338761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.3920387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.438761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8220387270
MESH:D009765 Obesity pirinixic acid 1.7420558911
MESH:D010003 Osteoarthritis Ibuprofen 7.717009135
MESH:D010003 Osteoarthritis rofecoxib 7.7116690336
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.9519769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms decitabine 13.9519331143 19259094
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.9517306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 13.9516936753
MESH:D010051 Ovarian Neoplasms trichostatin A 13.9519331143
MESH:D010146 Pain Acetaminophen 9.9716870215
MESH:D010146 Pain Ibuprofen 9.973291741
MESH:D010146 Pain Tretinoin 9.9716870215
MESH:D010149 Pain, Postoperative Ibuprofen 10.7416678543
MESH:D010149 Pain, Postoperative rofecoxib 10.7418165598 16678543
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 23.1912384795
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 23.1915580305
MESH:D010190 Pancreatic Neoplasms decitabine 23.1919294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 23.1916540662
MESH:D010190 Pancreatic Neoplasms Ibuprofen 23.1912384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 23.1915976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 23.1919294695
MESH:D010235 Paraganglioma arsenic trioxide 3.8919927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D010538 Peritonitis Ozone 3.8416369182
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.2011550810
MESH:D011014 Pneumonia Ozone 4.1018929643 18381685 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.312563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9011896295 11118676 11399792 11222880
MESH:D055728 Primary Myelofibrosis decitabine 11.4617616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.4617616702
MESH:D011471 Prostatic Neoplasms AGN 194204 2.0616000583
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0619131511
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.0617409433
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0616039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0618760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0615067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.0619789329 18798265
MESH:D011507 Proteinuria Ibuprofen 8.606375363
MESH:D011507 Proteinuria Tretinoin 8.6016636307
MESH:D011625 Pterygium Tretinoin 4.5016723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.2419058328
MESH:D012130 Respiratory Hypersensitivity trimellitic anhydride 4.6720219652
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012208 Rhabdomyosarcoma decitabine 10.0419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.0416116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6816646077
MESH:D012640 Seizures Mecamylamine 4.5512660363
MESH:D012878 Skin Neoplasms sodium arsenite 8.6118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.6116192470
MESH:D012878 Skin Neoplasms Tretinoin 8.6116467112
MESH:D013088 Spermatocele Tamoxifen 3.9916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7419457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5712854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 7.8917007042
MESH:D013274 Stomach Neoplasms decitabine 7.8919037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 7.8918456281
MESH:D013274 Stomach Neoplasms irinotecan 7.8915723263
MESH:D013274 Stomach Neoplasms N'-nitrosonornicotine 7.8918456281
MESH:D013274 Stomach Neoplasms Tretinoin 7.8917261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.2919014326
MESH:D013964 Thyroid Neoplasms decitabine 15.2917967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.297505956
MESH:D013964 Thyroid Neoplasms Tretinoin 15.2916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.5316051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6715213294
MESH:D014376 Tuberculosis Tretinoin 3.0516040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 10.9720435036 11780464 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms decitabine 10.9719087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.9716712894 16452187 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.9716712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 2.7110982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.5611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.5616129372
MESH:D014604 Uveal Neoplasms decitabine 11.8317785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.8316752155
MESH:D014652 Vascular Diseases sodium arsenite 4.1317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.8919057314
MESH:D014820 Vitiligo Tretinoin 3.7816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D009396 Wilms Tumor Tretinoin 3.7216287080
Pathway ID Pathway Name
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28586
    • No data
    No data
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved