AutismKB 2.0

Annotation Detail for FBXO25


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Basic Information Top
Gene Symbol:FBXO25 ( FBX25,MGC20256,MGC51975 )
Gene Full Name: F-box protein 25
Band: 8p23.3
Quick LinksEntrez ID:26260; OMIM: 609098; Uniprot ID:FBX25_HUMAN; ENSEMBL ID: ENSG00000147364; HGNC ID: 13596
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of FBXO25 mRNAincreases expression 19737606
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of FBXO25 mRNAdecreases expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of FBXO25 mRNAincreases expression 20106945
C056507 gemcitabine gemcitabine results in increased expression of FBXO25 mRNAincreases expression 17039268
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FBXO25 mRNAincreases expression 20106945
D014635 Valproic Acid Valproic Acid results in increased expression of FBXO25 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.9015322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.908875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D000236 Adenoma beta-Naphthoflavone 3.5019389873
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9916609825 15238991 20603192 17507914 18177632 18558336 18940202 18316065 19460635 18985861 17688650 19232924 18775368 17157402 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.2117594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.6515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.658888407
MESH:D001943 Breast Neoplasms gemcitabine 2.3517039268 18382427
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3520435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016050911 16227642 16011737 15700767 3786805 15673190 16124888 15721981 16097048 10355542 18705752 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8518788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7312371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2112621046 15340226 16354765 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5510048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5517688650 8888407 16575769
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.654309450 19085960 2869522 16177239 7440962 16227642 10915739 11566570 21278145 3786805 9327722 15998439 15968718 15027814 17522070 10092053 6623471 3732212 6884620 7179309 19336974 7120509
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.651733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.443922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.877562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.0912795759 19224547 15959796 61145 17595544 16045604 12631006 16239168
MESH:D005234 Fatty Liver Cyclosporine 15.0919224547
MESH:D005234 Fatty Liver Valproic Acid 15.0914986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.518888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 17.2918705752
MESH:D005355 Fibrosis Cyclosporine 17.2912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.2920067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 15340226 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16959395 18606429 16354765 15340226
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006973 Hypertension Cyclosporine 5.2810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.508314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0012371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9611903743 16943688 16221502 16239168 17174718 11408273 21278145 17334410 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3618339082 14512876 15996030 15730626 10355542 17481882 15123356 12546737 12586293 12898905 18205269 17805973 17708605 17823541 15362042 18006644 17721639 17698563 18279442 12445418 12741479 12666154 15650968 18472332 12667390 18251166 15893842 15370692 17525996 14620537 18166357 18376398 17565644 16638106 16011737 14724832 18317297 17922224 17640975 12632514 12445421 18472094 17976157 18210741 12609069 16136751 18395095 17869086 18420326 17557913 18705752 14716496 15876570 16248980 15057751 15925388 16027843 20821823 15959796 15673190 18263696 12649538 14716833 18054572 18156304 12389079 18429990 18277467 12632512 15818738 16192424 18412020 17631135 15931870 16116963 18395914 12958196 14748882 13678700 17714472 15052691 15338365 18187930 17761835 17944888 16015684 17900296 11481614 18481824 16097048 18418968 17766677 16033810
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1416964402 16246199 15720792 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9916899240 14706259
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 8.0421295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.0419294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0416984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.9418164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.9415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.9412151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.4118765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3117596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.328888407 16359493
MESH:D010190 Pancreatic Neoplasms gemcitabine 3.6211504793 18383843 17440100 18992248 16929163
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.0511118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 11.0520603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.0612752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.941511512 16876388 14763951 15475178 3137016 11738929 11044598 17978042
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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