AutismKB 2.0

Annotation Detail for TSPAN17


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Basic Information Top
Gene Symbol:TSPAN17 ( FBX23,FBXO23,MGC14859,MGC71255,TM4SF17 )
Gene Full Name: tetraspanin 17
Band: 5q35.2
Quick LinksEntrez ID:26262; OMIM: NA; Uniprot ID:TSN17_HUMAN; ENSEMBL ID: ENSG00000048140; HGNC ID: 13594
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TSPAN17 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TSPAN17 mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TSPAN17 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TSPAN17 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TSPAN17 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4711752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.3416124888 16227642 18705752 15673190 16097048 10355542 16011737 16050911 15721981 15700767 3786805 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.993084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9918788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1717333356 17681005 15861022 16105132 17110522 16919318 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2415668235 15340226 12621046 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 15322242 10048152
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6816109766 18713872 19370779 19416960 16227642 11739529 14986274 16177239 16485898 11421492 12594235 17906064 16081117 12540782 12392966 11743745 19164858 12705907 19923254 17522070 16393943 19085960 2444490 15968718 11834606 18071297 19420014 12153990 12958197 16781746 17562736 19739265 15619225 11287661 14550746 14725611 11461765 10915739 10774834 11529661 10663392
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.687179309 7120509 10915739 7440962 6884620 9327722 15027814 16177239 10092053 4309450 11566570 17522070 15968718 3732212 19085960 2869522 15998439 3786805 21278145 16227642 6623471 19336974
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6912538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.429294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.1417595544 19224547 12631006 16045604 12795759 61145 16239168 15959796
MESH:D005234 Fatty Liver Ethinyl Estradiol 9.1415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Carbon Tetrachloride 10.5318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.5320067830
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1019900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4512621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7716354765 8697196 16959395 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.1616899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.6515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.3716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.4012587719 15629191
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0017157831 21278145 11903743 17334410 16943688 17174718 11408273 16221502 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3814716496 15362042 17944888 16011737 18472332 15338365 15925388 12632514 15057751 15673190 12445418 17976157 17922224 18205269 12666154 12586293 16136751 20821823 17698563 18418968 18166357 11481614 16097048 17714472 12649538 12741479 16033810 17525996 12389079 17557913 14748882 15730626 17900296 15893842 16638106 12445421 12609069 15876570 18481824 18279442 18705752 17805973 16015684 15650968 18395095 18156304 14716833 12667390 17823541 18395914 14512876 18317297 18006644 15818738 18420326 17565644 17869086 14724832 18472094 17631135 18054572 16192424 14620537 12632512 15931870 12898905 15370692 18210741 17481882 18412020 18277467 18376398 15959796 17721639 16027843 18251166 18263696 13678700 15052691 12546737 15996030 16248980 17708605 18429990 17766677 10355542 17761835 15123356 12958196 17640975 16116963 18187930 18339082
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3812878042
MESH:D008107 Liver Diseases Acetaminophen 4.1611587558 16611625 19784758 12969438 19460945 12587719 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1615720792 16246199 15830285 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.7315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.7517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.7516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8019294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8016984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.5315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.5312151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211118676 11222880 11399792 11896295
MESH:D011537 Pruritus Ethinyl Estradiol 3.9416919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.6616709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
Pathway ID Pathway Name
KEGG:04142 Lysosome
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394740
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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