AutismKB 2.0

Annotation Detail for FBXO22


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Basic Information Top
Gene Symbol:FBXO22 ( FBX22,FISTC1,FLJ13986,MGC31799 )
Gene Full Name: F-box protein 22
Band: 15q24.2
Quick LinksEntrez ID:26263; OMIM: 609096; Uniprot ID:FBX22_HUMAN; ENSEMBL ID: ENSG00000167196; HGNC ID: 13593
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FBXO22 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FBXO22 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of FBXO22 mRNAdecreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FBXO22 proteinaffects expression 20106945
D026023 Permethrin Permethrin results in increased expression of FBXO22 mRNAincreases expression 19017407
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.9416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.9416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.947296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.9412619106 21507988 12907637
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.456135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.457505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4119486331 9022650
MESH:D019465 Craniofacial Abnormalities Permethrin 3.1919861644
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.5618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.5618551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2811298694 18759878 11906362 12868966 8970840 8156756 14531868 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 11.042952479 3621924
MESH:D003877 Dermatitis, Contact Permethrin 11.0414617103
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.7218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.7218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.7216192314 6482804 1440618 8291058 18289764 9328219 11289319 7440962 18692083 9653073 9022650 6679447 18648102
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007299 Insect Bites and Stings Permethrin 6.4415189238 12971516 12749493
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.2316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.2316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.236582329
MESH:D007938 Leukemia Permethrin 4.2812937054
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.409327722 15034207
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.977678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.9715890375 2125692 18177683 9163691
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 11.072876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 11.073712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 11.078603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8814755239
MESH:D009336 Necrosis 2,4-dinitrotoluene 12.2118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 12.2118551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 17.1716049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 17.1716049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 17.174026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.6518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.6518551238
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.156582329 1399818 7505956 3712494 6587162
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.9616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.9616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.968074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.8610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.8610091137
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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